Doctor MA Suk Ling                              Assistant Professor 馬淑玲博士 Fax: (852) 2667-5464 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

RESEARCH INTERESTS:

• Genetics of Alzheimer’s disease
• Development of molecular and bioinformatic methodologies and their applications to early detection of Alzheimer’s disease

SELECTED PUBLICATIONS:

1. Ma SL, Tang NLS, Wat KHY, Tang JHY, Lau KH, Law CB, Chiu J, Tam CCW, Poon TK, Lin KL, Kng CPL, Kong HL, Chan TY, Chan WC, Lam LCW. Effect of CYP2D6 and CYP3A4 Genotypes on the Efficacy of Cholinesterase Inhibitors in Southern Chinese Patients With Alzheimer's Disease. Am J Alzheimers Dis Other Demen. 2019 Aug;34(5):302-307.

2. Chen HY, Ma SL, Huang W, Ji L, Leung VH, Jiang H, Yao X, Tang NL. The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model. Sci Rep. 2016 Dec 2;6:38225.

3. Ma SL, Tang NL, Lam LC. Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer’s disease in a Chinese population. J Psychiatr Res. 2016, 76:143-7.

4. Zhou L, Ma SL, Yeung PK, Wong YH, Tsim KW, So KF, Lam LC, Chung SK. Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac. Transl Psychiatry. 2016 Sep 6;6(9):e881.

5. Ma SL, Pastorino L, Zhou XZ, Lu KP. Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease. J Biol Chem. 2012, 287(10):6969-73.

6. Ma SL, Tang NL, Tam CW, Lui VW, Lam LC, Chiu HF, Driver JA, Pastorino L, Lu KP. A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease. Neurobiol Aging. 2012, 33(4):804-13.