STAFFS

• Psychosomatic medicine
• Affective disorders and anxiety disorders
• Epidemiology and phenomenology of bipolar affective disorders
• Epidemiology of anxiety disorders
• Research on epidemiology, phenomenology, neuroimaging, development and evaluation of treatment modalities for functional gastrointestinal disorders

• American Gastroenterological Association – Digestive Disease Week 2015 -Recognition for Scientific Accomplishment as Early Stage Investigator – “Functional Dyspepsia-Post-Prandial Distress Syndrome is Associated with Increased Glutamate in the Somatosensory Cortex”
• New York Festivals 2017 World’s Best Radio Programs – Bronze Winner – “Madly Musical” – an RTHK4 radio program on the relationship between musical creativity and mental illnesses. (https://goo.gl/oZgVeZ ) (as guest presenter)

For study enquiries please email Dr. Mak directly at: arthurdpmak@cuhk.edu.hk

1. WHO World Mental Survey – International College Students project (coordinator of the WMH-ICS China consortium)
2. Incident mental morbidity and web-based psychological treatment in COVID-19 (a WMH-COVID 19 study).
   HMRF Project No: COVID190212; HKD 2940490; 2020-2022.(wmhsurvey.cuhk.edu.hk)
3. A randomized controlled trial of home-monitored ‘gut-directed’ versus ‘general’ Hatha yoga for adults with constipation-predominant irritable bowel syndrome;
   HMRF Project No.- 15160951; HKD 1086391; 1/8/2018 – 31/7/2020- PI.
4. Transcranial Magnetic Stimulation Treatment for Attention-Deficit
   Hyperactivity Disorder in Young Adults

1. Mak, ADP, Leung, O. N. W., Chou, I. W. Y., Wong, S. L. Y., Chu, W. C., Yeung, D., So, S. H., Ma, S. L., Lam, L. C. W., Leung, C. M. & Lee, S. (2021)
   White matter integrity in young medication-naive bipolar II depressed adults.
   Scientific Reports 11 (1), 1816.
2. So, S. H., Mak, ADP, Chan, P. S., Lo, C. C., Na, S., Leung, M. H., Ng, I. H., Chau, A. K. C. & Lee, S. (2020)
   Efficacy of Phase 1 of Life Goals Programme on symptom reduction and mood stability for bipolar disorder.
   J Affect Disord. 2021 Feb 15;281:949-957.
   doi: 10.1016/j.jad.2020.11.019. Epub 2020 Nov 18.
3. Karyotaki, E., Cuijpers, P., Albor, Y., Alonso, J., Auerbach, R. P., Bantjes, J., Bruffaerts, R., Ebert, D. D., Hasking, P., Kiekens, G., Lee, S., Mclafferty, M., Mak, ADP, Mortier, P., Sampson, N. A., Stein, D. J., Vilagut, G. & Kessler, R. C. (2020)
   Sources of Stress and Their Associations With Mental Disorders Among College Students: Results of the World Health Organization World Mental Health Surveys
   International College Student Initiative.
   Front Psychol. 2020 Jul 30;11:1759.
4. Mak, ADP, Ho, Y. M., Leung, O. N. W., Chou, I. W. Y., Lui, R., Wong, S., Yeung, D. K. W., Chu, W. C. W., Edden, R., Chan, S., Lam, L. & Wu, J. (2020b)
   Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression.
   Front Psychiatry. 2020 Sep 11;11:549749.
5. Mak, ADP, Chan, A. K. W., Chan, P. K. L., Tang, C. P., Lai, K., Wong, S., Leung, P., Hung, S. F., Lam, L. C. W. & Lee, S. (2020)
   Diagnostic Outcomes of Childhood ADHD in Chinese Adults.
   Journal of Attention Disorders 24 (1), 126-135.
6. Chan, Y., Cheong, P. K., Fang, F. F., Cheung, C. K. Y., Lan, L. L., Yuen, K. W. K., Ching, J. Y. L., Mak, ADP, Wu, J. C. (2020)
   A symptom severity questionnaire for patients suffering from functional gastrointestinal disorder: FGI-Checklist.
   Journal of Gastroenterology and Hepatology 35 (7), 1130-1135.
7. Wong KMF, Yuen SSY, Mak ADP.
   Neurocognitive Characteristics of Individuals with Irritable Bowel Syndrome.
   East Asian Arch Psychiatry. 2019 Jun;29(2):48-56.
8. Mak ADP, Wu JCY, Chan Y, Tse YK, Lee S.
   Associations between Gastro-oesophageal Reflux Disease, Generalised Anxiety Disorder, Major Depressive Episodes, and Healthcare Utilisation: a Community-based Study.
   East Asian Arch Psychiatry. 2019 Jun;29(2):41-47.
9. Wu IXY, Wong CHL, Ho RST, Cheung WKW, Ford AC, Wu JCY, Mak ADP, Cramer H, Chung VCH.
   Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis.
   Therap Adv Gastroenterol. 2019 Jan 20;12:1756284818820438.
10. Chan Y, So SH, Mak ADP, Siah KTH, Chan W, Wu JCY.
    The temporal relationship of daily life stress, emotions, and bowel symptoms in irritable bowel syndrome-Diarrhea subtype: A smartphone-based experience sampling study.
    Neurogastroenterol Motil. 2019 Mar;31(3):e13514.

ResearcherID:V-6345-2017
http://www.researcherid.com/rid/V-6345-2017
ORCID:
http://orcid.org/0000-0003-1627-6434
Google Scholar:
https://goo.gl/MFD45t

• Epidemiology and genetic epidemiology of sleep disorders
• Pathogenesis of insomnia disorder
• Mechanisms underlying the close associations of mood disorders with sleep disorders and circadian rhythms

• Circadian Rhythms dysregulation in the unaffected adolescent offspring of parents with bipolar I disorder
  躁鬱症患者的青少年子女晝夜節律失調研究
• Familial aggregation and biomarkers of REM sleep behavior disorder: a case-control family study
  快速眼動睡眠行為障礙的遺傳及生物標志物對照研究

1. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X.
   Response to commentary by Heidari and Arabzadeh on “Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis”.
   Sleep Med Rev. 2019 Aug;46:162-163.
2. Lim LL, Tse G, Choi KC, Zhang J, Luk AOY, Chow E, Ma RCW, Chan MHM, Wing YK, Kong APS, Chan JCN.
   Temporal changes in obesity and sleep habits in Hong Kong Chinese school children: a prospective study.
   Sci Rep. 2019 Apr 10;9(1):5881.
3. Liu Y, Zhang J, Lam SP, Yu MWM, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan A, Mok V, Wing YK.
   Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.
   Sleep Med. 2019 Apr;56:128-134.
4. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X.
   Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis.
   Sleep Med Rev. 2019 Jun;45:1-17.
5. Merikangas KR, Swendsen J, Hickie IB, Cui L, Shou H, Merikangas AK, Zhang J, Lamers F, Crainiceanu C, Volkow ND, Zipunnikov V.
   Real-time Mobile Monitoring of the Dynamic Associations Among Motor Activity, Energy, Mood, and Sleep in Adults With Bipolar Disorder.
   JAMA Psychiatry. 2018 Dec 12.
6. Wang F, Zhang L, Wu S, Li W, Sun M, Feng W, Ding D, Yeung-Shan Wong S, Zhu P, Evans GJ, Wing YK, Zhang J, Vlaanderen JJ, Vermeulen RCH, Zhang Y, Chan EY, Li Z, Tse LA.
   Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?
   Occup Environ Med. 2019 Feb;76(2):83-89.
7. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Med. 2019 Jan;53:1-8.
8. Rao S, Siu CO, Shi M, Zhang J, Lam MHB, Yu M, Wing YK, Waye MMY.
   Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model.
   Gene. 2018 Dec 30;679:382-388.
9. Suh S, Cho N, Zhang J.
   Sex Differences in Insomnia: from Epidemiology and Etiology to Intervention.
   Curr Psychiatry Rep. 2018 Aug 9;20(9):69.
10. Zhang J, Lam SP, Li SX, Liu Y, Chan JWY, Chan MHM, Ho CS, Li AM, Wing YK.
    Parental history of depression and higher basal salivary cortisol in unaffected child and adolescent offspring.
    J Affect Disord. 2018 Jul;234:207-213.

• Ph.D. in Medical Sciences, Faculty of Medicine, The Chinese University of Hong Kong (2016) 
• Master in Clinical Medicine, Jinan University (2012) 
• Bachelor in Clinical Medicine, Southern Medical University (2009)

• Young Investigator Award. Conference/organization: World Sleep 2017, World Association of Sleep Medicine and World Sleep Federation, Prague, Czech Republic. October 2017.
   
• Best Oral Presentation Award. Conference/organization: CUHK SLEEP 2016, The Chinese University of Hong Kong, Hong Kong. October 2016.

• Determine progression of idiopathic REM sleep behavior disorder towards neurodegenerative diseases and its biomarkers. 
• Examine the potential effective neuroprotective strategies in REM sleep behavior disorder to prevention Parkinson’s disease and dementia.

• 2018-2020 Postdoctoral Visiting Fellow in the Nuffield Department of Clinical Neurosciences, University of Oxford, UK 
• 2016-2018 Postdoctoral Fellow in the Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 
• 2009-2013 Resident in the Department of Psychiatry and Sleep Center, the First Affiliated Hospital, Jinan University, Guangzhou, China 
• 2007-2009 Internship: Internal Medicine, Surgery, Pediatrics and Gynaecology and Obstetrics. The Second Clinical Medical College, Zhujiang Hospital, Southern Medical University, Guangzhou, China

1. PI, Health and Medical Research Fund (08191416). Neural correlates of impulsivity in idiopathic REM sleep behavior disorder and Parkinson’s disease: a functional Magnetic Resonance Imaging case-control study. HK$ 1,122,120. 01/12/2021-30/11/2024. 
2. PI, Knowledge Transfer Project Fund (KPF21GWP26). Risk screening for prodromal Parkinson’s disease in elderly using smartphone. The Chinese University of Hong Kong. HK$ 395,380. 01/04/2021-31/03/2023. 
3. PI, Direct Grant for Research (2020.084). Impact of Long COVID–Neurodegenerative Perspective. CUHK. HK$ 149,000. 30/06/2021-29/06/2022.  
4. Co-PI, Collaborative Research Fund (C4044-21GF). Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha-synucleinopathy Neurodegeneration, in a Prospective Family Cohort. HK$ 7,214,620. 01/04/2022-31/03/2025. 
5. Co-PI, Collaborative Research Fund (C4061-21GF). Neuropsychiatric ‘long-COVID’ in adult patients. HK$ 3,251,480. 01/04/2022-31/03/2023. 
6. Co-I, General Research Fund (14108722). Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing. HK$ 1,300,000. Start in 2023. 
7. Co-I, Health and Medical Research Fund (18190931). AI-Based Day and Night Digital Phenotyping of Rapid Eye Movement (REM) Sleep Behaviors Disorder (RBD) and its Prediction towards α-Synucleinopathy. HK$ 1,495,330. Start in 2023. 
8. Co-I, Health and Medical Research Fund (09202766). Randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease.  HK$ 1,413,200. 01/08/2022-31/07/2025. 
9. Co-I, Health and Medical Research Fund (18190221). Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behaviour Disorder: tracing a subtype of depression with underlying neurodegeneration. HK$ 1,104,304. 01/10/2021-31/03/2024. 
10. Co-I, General Research Fund (14116121). Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. HK$ 1,130,208. 01/01/2022-31/12/2025. 
11. Co-I, Health and Medical Research Fund (06170676). A 7-year prospective study of idiopathic REM sleep behavior disorder cohort in Chinese population: determining the optimal characteristics of prodromal markers to predict neurodegenerative diseases. HK$ 1,250,616. 01/07/2019-30/06/2022. 
12. Co-I, National Natural Science Foundation of China (81471348). Mechanisms of Circadian Rhythms in the Progression of REM sleep behavior disorder towards neurodegeneration. CNY 70,000. 01/01/2015-31/12/2018. 

1. Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y.
   Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.
   J Sleep Res. 2022:e13791.
2. Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK*.
   Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study.
   Neurology. 2022;99(6):e627-e637.
3. Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M*, Wing YK*.
   Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.
   J Sleep Res. 2022:10.1111/jsr.13613.
4. Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT*.
   Longitudinal changes in Parkinson’s disease symptoms with and without REM sleep behavior disorder: the Oxford Discovery Cohort study.
   Mov Disord. 2021;36(12):2821-2832.
5. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MW, Chan NY, Chan JW, Li SX, Huang B, Feng H, Mok VCT, Wing YK*.
   Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.
   Mov Disord. 2020;35(11):2077-2085.
6. Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen J, Mok VCT, Wing YK*, Zhang J*.
   Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Ann Neurol. 2020;88(4):817-829.
7. Liu Y#, Zhang J#, Lam SP, Zhou J, Yu MWM, Li SX, Chan JW, Postuma RB, Mok VCT, Wing YK*.
   A case-control-family study of idiopathic rapid eye movement sleep behavior disorder.
   Ann Neurol. 2019;85(4):582-592.
8. Liu Y, Zhang J*, Lam SP, Yu MW, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan Anne, Mok VCT, Wing YK.
   Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.
   Sleep Med. 2019;56:128-134.
9. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK*.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Med. 2018, 24;53:1-8.
10. Liu Y, Zhang J, Lam V, Ho CK, Zhou J, Li SX, Lam SP, Yu MW, Tang X, Wing YK*.
    Altered Sleep Stage Transitions of REM Sleep: A Novel and Stable Biomarker of Narcolepsy.
    J Clin Sleep Med. 2015;11(8):885-94.

• Computational modelling of abnormal decision making processes in neuropsychiatric and neurodegenerative disorders
• Data-driven decision making in clinical management of neuropsychiatric and neurodegenerative disorders
• Multi-modal neuroimaging
• Neuropsychiatric disorders associated with Coronavirus (SARS/COVID)
• Novel approach in medical education

1. Prediction of 5-year risk of neurodegeneration in patients with idiopathic REM sleep behavior  disorder from multimodal neurodegenerative markers using deep neural network
2. Decision making in patients with idiopathic REM sleep behavior disorder and its neurobiological correlate

1. Chau, S.W.H., Wong, O.W.H., Ramakrishnan, R. et al.
   History for some or lesson for all? A systematic review and meta-analysis on the immediate and long-term mental health impact of the 2002–2003 Severe Acute Respiratory Syndrome (SARS) outbreak.
   BMC Public Health 2021 Apr 7;21(1):670.
2. Phiri P, Ramahrishnan R, Rathod S, Elliot K, Thayanandan T, Sandle N, Haque N, Chau SWH, Wong OWH, Chan SSM, Wong EKY, Raymont V, Kingdon D, Delanerolle GKE.
   An evaluation of the mental health impact of SARS-Cov-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis.
   EClinicalMedicine.2021 Apr;34:100806.
3. Chau, SWH.
   Antagonistic or inflexible? Exploring the underpinnings of ‘impulse dyscontrol’.
   International Psychogeriatrics, 2021 May 21;1-6.
4. H.J. Hopman, S.M.S. Chan, W.C.W. Chu, H. Lu, C.-Y. Tse, S.W.H. Chau, L.C.W. Lam, A.D.P. Mak, S.F.W. Neggers.
   Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning,
   Journal of Affective Disorders, 2021 Jul 1;290:261-271
5. Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SWH, Chen J, Tan X, Jia F, Tang X, Shi J, Lu Lin, Wing YK.
   Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
   European Heart Journal. 2021 Sep 7;42(34):3349-3357
6. Feng H, Chen L, Liu, Y, Chen, X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen, J, Mok VC, Wing YK and Zhang J.
   Rest‐activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Ann Neurol. 2020 Oct;88(4):817-829
7. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JWY, Li SX, Huang B, Feng H, Mok V, Wing YK.
   Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.
   Mov Disord. 2020 Nov;35(11):2077-2085
8. Chau SWH, Lewis T, Ng R, Chen JY, Farrell SM, Molodynski A, Bhugra D Wellbeing and mental health amongst medical students from Hong Kong. International Review of Psychiatry, Nov-Dec 2019;31(7-8):626-629
9. Molodynski A, Lewis T, Kadhum M, Farrell SM, Chelieh ML, De Almeida TF, Masri R, Kar A, Volpe U, Moir F, Torales J, Castaldelli-Maia JM, Chau SWH, Wilkes C, Bhugra D (2020).
   Cultural variations in wellbeing, burnout and substance use amongst medical students in twelve countries.
   International Review of Psychiatry, Feb-Mar 2021;33(1-2):37-42
10. Chau SW, Tse CY, So SH, Chan SS
    Attentional Bias Modification Training for Patients with Generalised Anxiety Disorder: a Randomised Controlled Study.
    East Asian Arch Psychiatry, 2019 Mar;29(1):3-9.

• Postdoctoral training at Department of Medicine, Harvard University

• 2005 Sir Edward Youde Memorial Fellowship

• Genetic susceptibility of neurodegenerative disorders, such as mild cognitive impairment and dementia
• Development of genetic markers for early detection of cognitive decline

1. Circulating cell-free mitochondrial DNA as marker for early detection of cognitive decline in elderly.
   (Funded by HMRF 2022; Capacity: PI)
2. Functional study of polymorphisms of inflammasome-related genes in Alzheimer’s disease.
   (Funded by CUHK Direct Grant 2022/2023. Capacity: PI)
3. Examining the genetic link of REM sleep behaviour disorder (RBD) and familial aggregation by whole exome sequencing (WES).
   (Funded by CUHK Direct Grant 2021/2022. Capacity: PI)
4. Mapping the Functional Significance of the Human Oxytocin Receptor Gene.(Funded by USYD-CUHK Partnership Collaboration Awards. Capacity: PI)
5. Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha- synucleinopathy Neurodegeneration, in a Prospective Family Cohort.
   (Funded by Collaborative Research Fund 2021/22; Capacity: Co-PI; PI: Prof YK Wing, Department of Psychiatry, CUHK)
6. Loneliness in Chinese older adults: Association with inflammation and cognitive decline. A 2-year longitudinal study.
   (Funded by GRF 2023/2024; Capacity: Co-I; PI: Dr Ada Fung, Department of Sport and Physical Education, HKBU)
7. Effect of a 6-week Integrated Attention Training Program on cognitive function in older adults with co-occurring anxiety symptoms and subjective cognitive complaints.
   (Funded by HMRF 2022; Capacity: Co-I; PI: Dr Ada Fung, Department of Sport and Physical Education, HKBU)
8. Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing.
   (Funded by GRF 2022/2023; Capacity: Co-I; PI: Prof YK Wing, Department of Psychiatry, CUHK)
9. Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning.
   (Funded by GRF 2022/2023; Capacity: Co-I; PI: Prof Sandra Chan, Department of Psychiatry, CUHK)
10. Development of a Single Cell Full-Length Mitochondrial Sequencing Platform based on Droplet Microfluidics.
    (Funded by GRF 2022/2023; Capacity: Co-I; PI: Dr Megan Ho, Department of Biomedical Engineering, CUHK)
11. Depressive Symptom Dynamics among Adolescents with Clinical and Subthreshold
    Depression – The Role of Stress on Symptom Connectedness.
    (Funded by HMRF 2022; Capacity: Co-I; PI: Prof. Suzanne Ho, Department of Psychology, CUHK)
12. Hong Kong Child and Adolescent Psychiatric Epidemiologic Survey: Age 6 to 17 (Funded by HMRF Commissioned Study 2018; Capacity: Co-I; PI: Prof. SF Hung, Department of Psychiatry, CUHK)
13. The Hong Kong Mental Morbidity Survey for Older Persons.
    (Funded by HMRF Commissioned Study 2018; Capacity: Co-I. PI: Prof. Linda Lam, Department of Psychiatry, CUHK)
14. Health determinants for late onset dementia and its associated mortality in Hong Kong Chinese older adults.
    (Funded by HMRF Commissioned Study 2018. Capacity: Co-I. PI: Prof. Linda Lam, Department of Psychiatry, CUHK)

1. Ma SL, Tang KT, Lau NCT, Chiu CLH, Lin C, Lam LCW, Lee ATC.
   Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression – a pilot randomized controlled trial.
   Front Psychiatry. 2024 Jan 17;14:1287822.
2. Fung AWT, Lee ATC, Ma SL, Lam LCW.
   Development and validation of cognitive ageing risk score (CARS) for early detection of subtle cognitive deficits in older people.
   BMC Geriatr. 2024 Mar 21;24(1):277.
3. Huang B, Huang J, Chiang NH, Chen Z, Lui G, Ling L, Kwan MYW, Wong JSC, Mak PQ, Ling JWH, Lam ICS, Ng RWY, Wang X, Gao R, Hui DS, Ma SL*, Chan PKS, Tang NLS.
   Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients.
   Front Immunol. 2024 Jan 10;14:1315602. *Corresponding author.
4. Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, Zhang J, Chan PKS, Yeoh YK, Chen Z, Zhou L, Wong SH, Mok VCT, To KF, Lai HM, Ng S, Trenkwalder C, Chan FKL, Wing YK.
   Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives.
   Nat Commun. 2023 May 2;14(1):2501.
5. Yeung SSY, Ma SL, Wang X, Chen Y, Tsui SKW, Tang NLS, Woo J.
   Telomere Length among Chinese Aged 75+ Years.
   Gerontology. 2023;69(12):1414-1423.
6. Ma SL, Chen LH, Lee CC, Lai KYC, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL.
   Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene.
   Front Neurosci. 2021, 27; 15:649588.
7. Ma SL, Wu J, Zhu L, Chan RS, Wang X, Huang D, Tang NL, Woo J.
   Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia.
   Nutrients. 2021;13(7):2313.
8. Ma SL, Tang NLS, Lam LCW.
   Promoter methylation and gene expression of Pin1 is associated to the risk on Alzheimer’s disease in Southern Chinese.
   Curr Alz Res. 2020; 17 (13):1232-1237.
9. Lee KY, Leung KS, Ma SL, So HC, Huang D, Tang NLS, Wong MH.
   Genome-wide search for SNP interactions in GWAS data: algorithm, feasibility, replication using schizophrenia datasets.
   Front. Genet. 2020; 11:1003.
10. Ma SL, Tang NLS, Wat KHY, Tang JHY, Lau KH, Law CB, Chiu J, Tam CCW, Poon TK, Lin KL,Kng CPL, Kong HL, Chan TY, Chan WC, Lam LCW.
    Effect of CYP2D6 and CYP3A4 genotypes on the efficacy of cholinesterase inhibitors in Southern Chinese patients with Alzheimer’s Disease.
    Am J Alzheimers Dis Other Demen. 2019; 34(5):302-307.
11. Lu H, Ma SL, Wong SW, Tam CW, Cheng ST, Chan SS, Lam LC.
    Aberrant interhemispheric functional connectivity within default mode network and its relationships with neurocognitive features in cognitively normal APOE ε 4 elderly carriers.
    IntPsychogeriatr. 2017; 29(5):805-814.
12. Zhou L, Ma SL*, Yeung PKK , Wong YH,Tsim KWK, So KF, Lam LCW and Chung SK
    Anxiety and depression with neurogenesis defects in Exchange Protein Directly Activated by cAMP (Epac) 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.
    Transl Psychiatry. 2016; 6:e881. *Co-1st author
13. Chen HY, Ma SL*, Huang W, Ji L, Leung VH, Jiang H, Yao X, Tang NL.
    The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model.
    Sci Rep. 2016; 2;6:38225. *Co-1st author