STAFFS

• Chemical and molecular biology tools for studying neuropsychiatric diseases
• Molecular and circuitry mechanisms of normal and pathological brain functioning
• Biomarkers for neuropsychiatric diseases
• Neuropsychopharmacology

• 46th International EXhibitions of Inventions Geneva, Switzerland, Gold Medal Award

• Advanced human and animal brain tissue research methods
• Biomarker discovery in psychiatric diseases

1. Thorlabs CMLS-F 4-channel Confocal Microscope
2. MesoSPIM Light Sheet Microscope (https://mesospim.org/setups/#)
3. Neuropixels 1.0 probes
4. Waters ACQUITY Arc Bio High-Performance Liquid Chromatography system

1. Zhao J, He D, Lai HM, Xu Y, Luo Y, Li T, Liang J, Yang X, Guo L, Ke Y, Zhou H, Wu W, Guo H, Sun H.
   Comprehensive histological imaging of native microbiota in human glioma.
   J Biophotonics. 2021 Dec 22:e202100351.
   doi: 10.1002/jbio.202100351.
2. Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H.
   Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner.
   Commun Biol. 2021 Jun 2;4(1):656.
3. Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL.
   Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
   ACS Cent Sci. 2021 May 26;7(5):792-802. doi: 10.1021/acscentsci.0c01186.
4. Lee K, Lai HM, Soerensen MH, Hui ES, Ma VW, Cho WC, Ho YS, Chang RC.
   Optimised tissue clearing minimises distortion and destruction during tissue delipidation.
   Neuropathol Appl Neurobiol. 2021 Apr;47(3):441-453. doi: 10.1111/nan.12673.
5. Zhao J, Lai HM, Qi Y, He D, Sun H.
   Current Status of Tissue Clearing and the Path Forward in Neuroscience.
   ACS Chem Neurosci. 2021 Jan 6;12(1)
6. Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H.
   Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.
   Nat Commun. 2020 Sep 4;11(1):4413.
7. Ren YX, Wu J, Lai QTK, Lai HM, Siu DMD, Wu W, Wong KKY, Tsia KK.
   Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array.
   Light Sci Appl. 2020 Jan 20;9:8.
8. Lai HM, Liu AKL, Ng HHM, Goldfinger MH, Chau TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM.
   Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.
   Nat Commun. 2018; 9:1066.
9. Lai HM, Ng WL, Gentleman SM, Wu W.
   Chemicals Probes for Visualizing Intact Animal and Human Brain Tissue.
   Cell Chem Biol 2017; 24:659-672.
10. Liu AKL, Lai HM, Chang RC, Gentleman SM.
    Free-of-acrylamide SDS-based Tissue Clearing (FASTClear): A novel protocol of tissue clearing for three-dimensional visualisation of human brain tissues.
    Neuropathol Appl Neurobiol. 2016; 43:346-351.

• Psychosomatic medicine
• Affective disorders and anxiety disorders
• Epidemiology and phenomenology of bipolar affective disorders
• Epidemiology of anxiety disorders
• Research on epidemiology, phenomenology, neuroimaging, development and evaluation of treatment modalities for functional gastrointestinal disorders

• American Gastroenterological Association – Digestive Disease Week 2015 -Recognition for Scientific Accomplishment as Early Stage Investigator – “Functional Dyspepsia-Post-Prandial Distress Syndrome is Associated with Increased Glutamate in the Somatosensory Cortex”
• New York Festivals 2017 World’s Best Radio Programs – Bronze Winner – “Madly Musical” – an RTHK4 radio program on the relationship between musical creativity and mental illnesses. (https://goo.gl/oZgVeZ ) (as guest presenter)

For study enquiries please email Dr. Mak directly at: arthurdpmak@cuhk.edu.hk

1. WHO World Mental Survey – International College Students project (coordinator of the WMH-ICS China consortium)
2. Incident mental morbidity and web-based psychological treatment in COVID-19 (a WMH-COVID 19 study).
   HMRF Project No: COVID190212; HKD 2940490; 2020-2022.(wmhsurvey.cuhk.edu.hk)
3. A randomized controlled trial of home-monitored ‘gut-directed’ versus ‘general’ Hatha yoga for adults with constipation-predominant irritable bowel syndrome;
   HMRF Project No.- 15160951; HKD 1086391; 1/8/2018 – 31/7/2020- PI.
4. Transcranial Magnetic Stimulation Treatment for Attention-Deficit
   Hyperactivity Disorder in Young Adults

1. Mak, ADP, Leung, O. N. W., Chou, I. W. Y., Wong, S. L. Y., Chu, W. C., Yeung, D., So, S. H., Ma, S. L., Lam, L. C. W., Leung, C. M. & Lee, S. (2021)
   White matter integrity in young medication-naive bipolar II depressed adults.
   Scientific Reports 11 (1), 1816.
2. So, S. H., Mak, ADP, Chan, P. S., Lo, C. C., Na, S., Leung, M. H., Ng, I. H., Chau, A. K. C. & Lee, S. (2020)
   Efficacy of Phase 1 of Life Goals Programme on symptom reduction and mood stability for bipolar disorder.
   J Affect Disord. 2021 Feb 15;281:949-957.
   doi: 10.1016/j.jad.2020.11.019. Epub 2020 Nov 18.
3. Karyotaki, E., Cuijpers, P., Albor, Y., Alonso, J., Auerbach, R. P., Bantjes, J., Bruffaerts, R., Ebert, D. D., Hasking, P., Kiekens, G., Lee, S., Mclafferty, M., Mak, ADP, Mortier, P., Sampson, N. A., Stein, D. J., Vilagut, G. & Kessler, R. C. (2020)
   Sources of Stress and Their Associations With Mental Disorders Among College Students: Results of the World Health Organization World Mental Health Surveys
   International College Student Initiative.
   Front Psychol. 2020 Jul 30;11:1759.
4. Mak, ADP, Ho, Y. M., Leung, O. N. W., Chou, I. W. Y., Lui, R., Wong, S., Yeung, D. K. W., Chu, W. C. W., Edden, R., Chan, S., Lam, L. & Wu, J. (2020b)
   Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression.
   Front Psychiatry. 2020 Sep 11;11:549749.
5. Mak, ADP, Chan, A. K. W., Chan, P. K. L., Tang, C. P., Lai, K., Wong, S., Leung, P., Hung, S. F., Lam, L. C. W. & Lee, S. (2020)
   Diagnostic Outcomes of Childhood ADHD in Chinese Adults.
   Journal of Attention Disorders 24 (1), 126-135.
6. Chan, Y., Cheong, P. K., Fang, F. F., Cheung, C. K. Y., Lan, L. L., Yuen, K. W. K., Ching, J. Y. L., Mak, ADP, Wu, J. C. (2020)
   A symptom severity questionnaire for patients suffering from functional gastrointestinal disorder: FGI-Checklist.
   Journal of Gastroenterology and Hepatology 35 (7), 1130-1135.
7. Wong KMF, Yuen SSY, Mak ADP.
   Neurocognitive Characteristics of Individuals with Irritable Bowel Syndrome.
   East Asian Arch Psychiatry. 2019 Jun;29(2):48-56.
8. Mak ADP, Wu JCY, Chan Y, Tse YK, Lee S.
   Associations between Gastro-oesophageal Reflux Disease, Generalised Anxiety Disorder, Major Depressive Episodes, and Healthcare Utilisation: a Community-based Study.
   East Asian Arch Psychiatry. 2019 Jun;29(2):41-47.
9. Wu IXY, Wong CHL, Ho RST, Cheung WKW, Ford AC, Wu JCY, Mak ADP, Cramer H, Chung VCH.
   Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis.
   Therap Adv Gastroenterol. 2019 Jan 20;12:1756284818820438.
10. Chan Y, So SH, Mak ADP, Siah KTH, Chan W, Wu JCY.
    The temporal relationship of daily life stress, emotions, and bowel symptoms in irritable bowel syndrome-Diarrhea subtype: A smartphone-based experience sampling study.
    Neurogastroenterol Motil. 2019 Mar;31(3):e13514.

ResearcherID:V-6345-2017
http://www.researcherid.com/rid/V-6345-2017
ORCID:
http://orcid.org/0000-0003-1627-6434
Google Scholar:
https://goo.gl/MFD45t

• Epidemiology and genetic epidemiology of sleep disorders
• Pathogenesis of insomnia disorder
• Mechanisms underlying the close associations of mood disorders with sleep disorders and circadian rhythms

• Circadian Rhythms dysregulation in the unaffected adolescent offspring of parents with bipolar I disorder
  躁鬱症患者的青少年子女晝夜節律失調研究
• Familial aggregation and biomarkers of REM sleep behavior disorder: a case-control family study
  快速眼動睡眠行為障礙的遺傳及生物標志物對照研究

1. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X.
   Response to commentary by Heidari and Arabzadeh on “Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis”.
   Sleep Med Rev. 2019 Aug;46:162-163.
2. Lim LL, Tse G, Choi KC, Zhang J, Luk AOY, Chow E, Ma RCW, Chan MHM, Wing YK, Kong APS, Chan JCN.
   Temporal changes in obesity and sleep habits in Hong Kong Chinese school children: a prospective study.
   Sci Rep. 2019 Apr 10;9(1):5881.
3. Liu Y, Zhang J, Lam SP, Yu MWM, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan A, Mok V, Wing YK.
   Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.
   Sleep Med. 2019 Apr;56:128-134.
4. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X.
   Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis.
   Sleep Med Rev. 2019 Jun;45:1-17.
5. Merikangas KR, Swendsen J, Hickie IB, Cui L, Shou H, Merikangas AK, Zhang J, Lamers F, Crainiceanu C, Volkow ND, Zipunnikov V.
   Real-time Mobile Monitoring of the Dynamic Associations Among Motor Activity, Energy, Mood, and Sleep in Adults With Bipolar Disorder.
   JAMA Psychiatry. 2018 Dec 12.
6. Wang F, Zhang L, Wu S, Li W, Sun M, Feng W, Ding D, Yeung-Shan Wong S, Zhu P, Evans GJ, Wing YK, Zhang J, Vlaanderen JJ, Vermeulen RCH, Zhang Y, Chan EY, Li Z, Tse LA.
   Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator?
   Occup Environ Med. 2019 Feb;76(2):83-89.
7. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Med. 2019 Jan;53:1-8.
8. Rao S, Siu CO, Shi M, Zhang J, Lam MHB, Yu M, Wing YK, Waye MMY.
   Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model.
   Gene. 2018 Dec 30;679:382-388.
9. Suh S, Cho N, Zhang J.
   Sex Differences in Insomnia: from Epidemiology and Etiology to Intervention.
   Curr Psychiatry Rep. 2018 Aug 9;20(9):69.
10. Zhang J, Lam SP, Li SX, Liu Y, Chan JWY, Chan MHM, Ho CS, Li AM, Wing YK.
    Parental history of depression and higher basal salivary cortisol in unaffected child and adolescent offspring.
    J Affect Disord. 2018 Jul;234:207-213.

• Ph.D. in Medical Sciences, Faculty of Medicine, The Chinese University of Hong Kong (2016) 
• Master in Clinical Medicine, Jinan University (2012) 
• Bachelor in Clinical Medicine, Southern Medical University (2009)

• Young Investigator Award. Conference/organization: World Sleep 2017, World Association of Sleep Medicine and World Sleep Federation, Prague, Czech Republic. October 2017.
   
• Best Oral Presentation Award. Conference/organization: CUHK SLEEP 2016, The Chinese University of Hong Kong, Hong Kong. October 2016.

• Determine progression of idiopathic REM sleep behavior disorder towards neurodegenerative diseases and its biomarkers. 
• Examine the potential effective neuroprotective strategies in REM sleep behavior disorder to prevention Parkinson’s disease and dementia.

• 2018-2020 Postdoctoral Visiting Fellow in the Nuffield Department of Clinical Neurosciences, University of Oxford, UK 
• 2016-2018 Postdoctoral Fellow in the Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 
• 2009-2013 Resident in the Department of Psychiatry and Sleep Center, the First Affiliated Hospital, Jinan University, Guangzhou, China 
• 2007-2009 Internship: Internal Medicine, Surgery, Pediatrics and Gynaecology and Obstetrics. The Second Clinical Medical College, Zhujiang Hospital, Southern Medical University, Guangzhou, China

1. PI, Health and Medical Research Fund (08191416). Neural correlates of impulsivity in idiopathic REM sleep behavior disorder and Parkinson’s disease: a functional Magnetic Resonance Imaging case-control study. HK$ 1,122,120. 01/12/2021-30/11/2024. 
2. PI, Knowledge Transfer Project Fund (KPF21GWP26). Risk screening for prodromal Parkinson’s disease in elderly using smartphone. The Chinese University of Hong Kong. HK$ 395,380. 01/04/2021-31/03/2023. 
3. PI, Direct Grant for Research (2020.084). Impact of Long COVID–Neurodegenerative Perspective. CUHK. HK$ 149,000. 30/06/2021-29/06/2022.  
4. Co-PI, Collaborative Research Fund (C4044-21GF). Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha-synucleinopathy Neurodegeneration, in a Prospective Family Cohort. HK$ 7,214,620. 01/04/2022-31/03/2025. 
5. Co-PI, Collaborative Research Fund (C4061-21GF). Neuropsychiatric ‘long-COVID’ in adult patients. HK$ 3,251,480. 01/04/2022-31/03/2023. 
6. Co-I, General Research Fund (14108722). Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing. HK$ 1,300,000. Start in 2023. 
7. Co-I, Health and Medical Research Fund (18190931). AI-Based Day and Night Digital Phenotyping of Rapid Eye Movement (REM) Sleep Behaviors Disorder (RBD) and its Prediction towards α-Synucleinopathy. HK$ 1,495,330. Start in 2023. 
8. Co-I, Health and Medical Research Fund (09202766). Randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease.  HK$ 1,413,200. 01/08/2022-31/07/2025. 
9. Co-I, Health and Medical Research Fund (18190221). Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behaviour Disorder: tracing a subtype of depression with underlying neurodegeneration. HK$ 1,104,304. 01/10/2021-31/03/2024. 
10. Co-I, General Research Fund (14116121). Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. HK$ 1,130,208. 01/01/2022-31/12/2025. 
11. Co-I, Health and Medical Research Fund (06170676). A 7-year prospective study of idiopathic REM sleep behavior disorder cohort in Chinese population: determining the optimal characteristics of prodromal markers to predict neurodegenerative diseases. HK$ 1,250,616. 01/07/2019-30/06/2022. 
12. Co-I, National Natural Science Foundation of China (81471348). Mechanisms of Circadian Rhythms in the Progression of REM sleep behavior disorder towards neurodegeneration. CNY 70,000. 01/01/2015-31/12/2018. 

1. Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y.
   Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.
   J Sleep Res. 2022:e13791.
2. Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK*.
   Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study.
   Neurology. 2022;99(6):e627-e637.
3. Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M*, Wing YK*.
   Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.
   J Sleep Res. 2022:10.1111/jsr.13613.
4. Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT*.
   Longitudinal changes in Parkinson’s disease symptoms with and without REM sleep behavior disorder: the Oxford Discovery Cohort study.
   Mov Disord. 2021;36(12):2821-2832.
5. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MW, Chan NY, Chan JW, Li SX, Huang B, Feng H, Mok VCT, Wing YK*.
   Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.
   Mov Disord. 2020;35(11):2077-2085.
6. Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen J, Mok VCT, Wing YK*, Zhang J*.
   Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Ann Neurol. 2020;88(4):817-829.
7. Liu Y#, Zhang J#, Lam SP, Zhou J, Yu MWM, Li SX, Chan JW, Postuma RB, Mok VCT, Wing YK*.
   A case-control-family study of idiopathic rapid eye movement sleep behavior disorder.
   Ann Neurol. 2019;85(4):582-592.
8. Liu Y, Zhang J*, Lam SP, Yu MW, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan Anne, Mok VCT, Wing YK.
   Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study.
   Sleep Med. 2019;56:128-134.
9. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK*.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Med. 2018, 24;53:1-8.
10. Liu Y, Zhang J, Lam V, Ho CK, Zhou J, Li SX, Lam SP, Yu MW, Tang X, Wing YK*.
    Altered Sleep Stage Transitions of REM Sleep: A Novel and Stable Biomarker of Narcolepsy.
    J Clin Sleep Med. 2015;11(8):885-94.

• Community and rehabilitation in psychiatry

• Addiction psychiatry

• General adult psychiatry

• General adult psychiatry

• Psychiatry
• Health service management

• Early psychosis
• Schizophrenia
• Forensic psychiatry
• Neuropsychiatry

• Cambridge University in Research Method and Forensic Psychiatry, under Dr. German Berrios and Dr. Adrian Grounds in 1992

• The Chief Executive’s Commendation for Community Service, Hong Kong SAR in 2013, for contribution to the rehabilitation service for ex-offenders under various boards

1. W.S.D. Chung, H.F.K. Chiu.
   Drug-induced Akathisia-revisited.
   British Journal of Clinical Practice 1996 Vol.50 (5) 270-278.
2. W.S. Chung, Y.K. Wing, H.F.K. Chiu, T.S. Lee, C. N. Chen.
   Misdiagnoses in a Chinese narcoleptic patient with delayed onset cataplexy.
   British Journal of Clinical Practice 1997 Vol 51(3): 186-188.
3. W S D Chung, C M Leung.
   Carbon monoxide poisoning as a new method of suicide in Hong Kong.
   Psychiatric Services 2001 Vol. 52 836-837.
4. Dicky W S Chung.
   Biomedical approach is not good enough for treating severe mental illness.
   East Asian Archives of Psychiatry 2010; 20: 4-5
5. Eric YH Chen, Christy LM Hui, May ML Lam, Cindy PY Chiu, CW Law, Dicky WS Chung, et al.
   Maintenance treatment with Quetiapine versus discontinuation after one year treatment in patients with remitted first episode psychosis: a randomised control trial.
   BMJ 2010; 341:c4024

• Psychiatry

• Consultation liaison psychiatry
• Perinatal psychiatry

• Forensic psychiatry – Assessment of the psychiatric injuries / disabilities of personal injuries, assessment of mental capacity
• Management of psychiatric conditions of psychoactive substance abusers and people with HIV
• Psychotherapy
• Promotion of public mental health

• Honarary Consultant, Against Child Abuse
• Honarary Advisor, Project Aspire, Institute of Education
• Executive Committee Member, Society of Boys’ Centres

• Eating disorders
• ADHD service related research

1. Li Y, Hou CL, Ma XR, Zang Y, Jia FJ, Lai KYC, Ungvari GS, Ng CH, Cai MY, Xiang YT. Nicotine dependence in community-dwelling Chinese patients with schizophrenia. Gen Psychiatr. 2019 Feb 23;32(1):e100014.
2. Chan SKC, Zhang D, Bögels SM, Chan CS, Lai KYC, Lo HHM, Yip BHK, Lau ENS, Gao TT, Wong SYS. Effects of a mindfulness-based intervention (MYmind) for children with ADHD and their parents: protocol for a randomised controlled trial. BMJ Open. 2018 Nov 12;8(11):e022514.
3. Ma JLC, Lai KYC, Xia LLL. Treatment Efficacy of Multiple Family Therapy for Chinese Families of Children with Attention Deficit Hyperactivity Disorder. Fam Process. 2018 Jun;57(2):399-414.
4. Lai KYC, Ma JLC, Xia LLL. Multifamily Therapy for Children With ADHD in Hong Kong: The Different Impacts on Fathers and Mothers. J Atten Disord. 2018 Feb 1:1087054718756195.
5. Li Y, Hou CL, Ma XR, Zhong BL, Zang Y, Jia FJ, Lin YQ, Lai KYC, Chiu HFK, Ungvari GS, Hall BJ, Cai MY, Ng CH, Xiang YT. Quality of life in Chinese patients with schizophrenia treated in primary care. Psychiatry Res. 2017 Aug;254:80-84.
6. Wan ESF, Ma JLC, Lai KYC, Lo JWK. The Subjective Experiences of Attention-Deficit/Hyperactivity Disorder of Chinese Families in Hong Kong: Co-Construction of Meanings in Multiple Family Groups. Health Soc Work. 2016 Aug 1;41(3):164-172.
7. Shea CKS, Lee MMC, Lai KYC, Luk ESL, Leung PWL. Prevalence of Anxiety Disorders in Hong Kong Chinese Children With ADHD. J Atten Disord. 2018 Mar;22(5):403-413.

• Substance abuse

• My substance abuse unit was awarded with outstanding team of HA in 2016

• Child and adolescent psychiatry
• Substance misuse psychiatry
• Electroconvulsive therapy
• Transcranial magnetic stimulation

• Adult psychiatry
• Child and adolescent psychiatry
• Jungian analysis
• Sandplay therapy

• Jungian Analyst under International Association for Analytical Psychology

• Psychiatry

• General adult psychiatry
• Psychopharmacology
• Neurobiology

• HA KCH Outstanding Team Award 2012 – Co-leader, Personalized Care Programme (Kwai Tsing District) (PCP (KT)) for Patients with Severe Mental Illness (SMI), KCH
• Best Oral Presentation Award, “One-year outcome of a district-based Kwai Tsing Personalized Care Program for patients with severe mental illness using a recovery-orientated case management approach in Hong Kong”, HA Convention, 2012
• Best Oral Presentation Award, “General Adult Services”, KCH Strategies & Team Building Workshop, KCH, 2013
• Commendation Award, “One-year outcome of a district-based Kwai Tsing Personalized Care Program for patients with severe mental illness using a recovery-orientated case management approach in Hong Kong”, Kowloon West Cluster (KWC), HA, 2013
• Certificate of Merits for Oral Presentation, “One-year outcome and association factors of administrative and clinical parameters in Personalized Care Programme (Kwai Tsing District) (PCP (KT)): new findings”, HA Convention, 2014
• Best Oral Presentation Award, “One-year outcome and association factors of administrative and clinical parameters in Personalized Care Programme (Kwai Tsing District) (PCP (KT)): new findings”, HA Convention, 2014
• Commendation Award, “One-year outcome and association factors of administrative and clinical parameters in Personalized Care Programme (Kwai Tsing District) (PCP (KT)): new findings”, Kowloon West Cluster (KWC), HA, 2015
• HA KCH Outstanding Team Award 2017 – Subject Officer, Common Mental Disorder Clinic, KCH
• Commendation Award, Chairman of HA Workplace Violence (WV) Working Group, Occupational & Safety Health (OSH) Forum, HA, 2019
• Certificate of Recognition, Chairman of HA WV Working Group, OSH, HA, 2019
• HA Head Office Outstanding Staff and Team Award 2019 – Chairman of HA WV Working Group, OSH, HA

1. WK Lee.
   Management of depression by restoring circadian rhythm.
   Journal of The Society of Physicians of Hong Kong, September 2011, vol.3, no. 5, p 71-72
2. WK Lee, Kenny K Wong, Y Chow, SF Chan, PS Wong, Bonson HK Kan, MS Li, Margaret Tay, Patrick Kwong, William TL Lo, SF Hung.
   One-year outcome of a district-based Kwai Tsing Personalized Care Programme for patients with severe mental illness using a recovery-orientated case management approach in Hong Kong.
   Hong Kong Journal of Mental Health 2011, Vol 37(2), p.43-55
3. WK Lee.
   New treatment option in major depressive disorder.
   Journal of The Society of Physicians of Hong Kong July 2012 vol.4, No. 4, Page 45-48
4. WK Lee.
   Update of international treatment guidelines for bipolar disorder.
   Journal of The Society of Physicians of Hong Kong July 2013, Vol.5, No.4
5. WK Lee, AWF Lo, G Chong, SYS Chang, VWY Lu, IPL Yip, CMK Liu, M Leung, CM Chung, KY Wong, YYE Yeung, SMA Chan, YS Ngai, PS Wong, WTL Lo.
   New Service Model for Common Mental Disorders in Hong Kong: a Retrospective Outcome Study.
   East Asian Archives of Psychiatry, 2019; 29: 75-80.

• Mood disorder
• Organic psychiatry
• Forensic psychiatry

1. Leung CM, Chan YW, Chang CM, Yu YL, & Chen CN.
   Huntington’s disease in Chinese: a hypothesis of its origin.
   J Neurology, Neurosurgery and Psychiatry 1992: 55:681-684
2. Leung CM, Lee G, Cheung B, Kwong E, Wing YK, Kan & Lau J.
   Karaoke therapy in the rehabilitation of mental patients.
   Singapore Med J 1998:39:166-168
3. Leung CM, Chung WS & EPM So.
   Burning Charcoal – An indigenous method of committing suicide in Hong Kong.
   J Clin Psychiatry 2002:63:447-450
4. Leung CM, Yim CL, Yan CT, Chan CC, Xiang YT, Mak AD, Fok ML, Ungvari GS.
   The Bipolar II Depression Questionnaire: A self-report tool for detecting bipolar II depression.
   PLoS One. 2016;11:e0149752
5. Tse AC, Fok MLY, Yim LC, Leung MMW, Leung CM.
   Diagnostic conversion to bipolar disorder in unipolar depressed patients in Hong Kong: A 20-year follow-up study.
   J Affect Disord. 2021;286:94-98.

• Specialist in psychiatry

• Prolonged grief disorder
• Complicated grief treatment
• Bereavement related mental health issues

• Certified therapist and trainer for Complicated Grief Treatment, The Center for Complicated Grief, Columbia University, USA
• Certified Cognitive-behavioral Therapist, The Academy of Cognitive Therapy, USA
• Practitioner of Child-Parent Psychotherapy, The University of California, San Francisco, USA

• 2018 Younger Achiever Award, Kowloon East Cluster, Hospital Authority
• Fellow in Thanatology (F.T.). The Association for Death Education and Counseling, USA

1. Adrian Kwan-Ho Sham, Michael Gar-chung Yiu and Winsom Yau-bong Ho
   Psychiatric morbidity following miscarriage in Hong Kong
   General Hospital Psychiatry 32 (2010), 284-293
2. Adrian KH Sham, Peter WC Tam, Gillian PK Wong, Michael GC Yiu
   Update on grief and complicated grief, and an introduction to the specialized treatment programme for complicated grief in the common mental disorder clinic of the United Christian Hospital
   The Hong Kong Practitioner, Vol 35, December 2013
3. Dr. Sham Kwan Ho
   A brief revisit to grief and complicated grief
   Asian traumatic stress points, issue no.13, April 2013

• Psychiatry

• Chief of Service (Psychiatry), Prince of Wales Hospital & Shatin Hospital, New Territories East Cluster (NTEC), Hospital Authority, Hong Kong (2018 – )
• Consultant, Department of Psychiatry, NTEC, Hospital Authority –  Subspecialty: Old Age Psychiatry (2011 – )
• Member of the Hong Kong Guardianship Board (2020 – )
• Member, Education Committee, The Hong Kong College of Psychiatrists, Hong Kong Academy of Medicine (2022 – )
• NTE Cluster Coordinator for the Dementia Community Support Scheme (DCSS) of the Food & Health Bureau (2017 – )
• Territory-wide Coordinator for the Elderly Suicide Prevention Program (ESPP) and Chair of the ESPP Committee, Headquarter, Hospital Authority (2010 – )
• Chair of the NTEC Suicide Prevention Sub-Committee (under the NTEC Quality & Safety Committee) (2017 -)
• Member on the Expert Panel on Psychiatric Drugs, Headquarter, Hospital Authority (2013 – )
• Chairman, Quality Assurance (QA) Meeting, Department of Psychiatry, Prince of Wales & Shatin Hospitals (2006 – )

• The Yao Yiu Sai Education and Charitable Memorial Scholarship of the Hong Kong College of Psychiatrists:
  Best Research Work of the Year by Senior Trainees in the FHKCPsych Exit Examination (2003)
• Pfizer-Hong Kong Psychogeriatric Association (HKPGA) Research Awards: First Prize (2003)

• Visiting Fellowship, Department of Psychiatry, The University of Rochester Medical Center (URMC), New York, U.S.A. (2014)

• Dementia
• Suicide
• Depression
• Mental capacity (assessment and related legislations around the world)
• Personality studies
• Sleep medicine

1. Chiu, H., & Tsoh, J. (2014).
   Suicide and attempted suicide in older people. In T. Dening & A. Thomas (Eds.),
   The Oxford Textbook of Old Age Psychiatry, 2nd Edition (pp. 581-589). Cambridge, UK: Cambridge University Press.
2. Tsoh, J., Peisah, C., Narumoto, J., et al. (2015).
   Comparisons of guardianship laws and surrogate decision-making practices in China, Japan, Thailand, and Australia: A review by the Asia Consortium, International Psychogeriatric Association (IPA) Capacity Taskforce.
   International Psychogeriatrics, 27(6), 1029-1037.
3. Tsoh, J., Chiu, H. F., Duberstein, P. R., Chan, S. S., Chi, I., Yip, P. S., & Conwell, Y. (2005).
   Attempted suicide in elderly Chinese persons: A multi-group, controlled study.
   American Journal of Geriatric Psychiatry, 13(7), 562-571.
4. Chiu, H. F., Yip, P. S., Chi, I., Chan, S., Tsoh, J., Kwan, C. W., et al. (2004).
   Elderly suicide in Hong Kong–a case-controlled psychological autopsy study.
   Acta Psychiatrica Scandinavica, 109(4), 299-305.
5. Tee, B. L., Kwan-Chen, L. Y. L., Chen, T. F., Yan, C. T. Y., Tsoh, J., Chan, A. L. T., et al. (2022).
   Dysgraphia phenotypes in Chinese Language Users with Primary Progressive Aphasia.
   Neurology, 98(22), e2245-e2257. doi: 0.1212/WNL.0000000000200350
6. Tee, B. L., Gorno Tempini, M. L., Chen, T. F., Lo, R. Y., Wang, P. N., LT, A., Kwan Chen, L. L. Y., Wong, A., Yan, C. T. Y., Tsoh, J., & Lu, C. J. (2021).
   Another side of the coin: Primary progressive aphasia in Chinese language.
   Alzheimer’s & Dementia. https://doi.org/10.1002/alz.12333
7. Chang, W. T., Ng, I. H. Y., Cheung, C. M. K., Tsang, M. O., Tam, A. Y., Chan, C., Chan, L.W.L., Tsoh, J et al. (2022).
   Targeted Screening in Older Adults: Hearing Loss and Mild Cognitive Impaired.
   Journal of Community Medicine and Public Health, 6, 269. doi: https://doi.org/10.29011/2577-2228.100269
8. Chan, S. S., Leung, V. P., Tsoh, J., et al. (2011).
   Outcomes of a two-tiered multifaceted elderly suicide prevention program in a Hong Kong Chinese community.
   American Journal of Geriatric Psychiatry, 19(2), 185-196.
9. Chiu, H., & Tsoh, J. (2010).
   Sleep and Ageing: Disorders and Management.
   In M. T. Abou-Saleh, C. Katona, & A. Kumar (Eds.), Principles and Practice of Geriatric Psychiatry (pp. 633-640). Chichester, UK: Wiley-Blackwell. https://doi.org/10.1002/9780470669600.ch111
10. Baum, L., Lam, C. W., Cheung, S. K., Kwok, T., Lui, V., Tsoh, J., et al. (2008).
    Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease.
    Journal of Clinical Psychopharmacology, 28(1), 110-113. doi: 10.1097/JCP.0b013e318160862c

1. The Concept of “Mentally-Incapacitated Persons” (MIPs)” and the Roles of Relatives on Medical Treatment Decisions
   Concept, Scope and Applicability of Medical Guidelines issued by the Guardianship Board
   Jointly held by the Task Force on Laws for Healthcare Practitioners Professionalism and Ethics Committee, Hong Kong Academy of Medicine (HKAM) and the Guardianship Board  (Oct 12, 2022, Hong Kong)
2.    Medical-Social Collaboration on Elderly Depression: The “Bridging & Liaison to Ensure Successful Support for Elderly Depressives (BLESSED)” Program. The 3rd International Symposium on Promoting Mental Wellbeing in Ageing Communities: Policy, Practice, and Public Awareness. Department of Social Work and Social Administrations, Faculty of Social Sciences, The University of Hong Kong (Aug 2, 2019, Hong Kong)
3. Capacity and Patient Autonomy in Old Age. Symposium on Supporting Patient Autonomy in Old Age and Death. The Centre for Medical Ethics and Law (CMEL), Faculty of Law, University of Hong Kong (Jun 5, 2015, Hong Kong)

• Specialist in psychiatry
• Teaching psychodynamic psychotherapy

• Ten Outstanding Young Persons Award 1992
• Justice of Peace (JP) Appointment 2002

1. Peter Ting-kwok Tsoi, Benjamin Lai, Kwai-wah Hong
   Trainees’ Forum: Experiences and Viewpoints of Psychotherapy Trainees
   Bulletin of the Royal College of Psychiatrists, Vol 10, December 1986
   (Paper presented at the 1st Eastern Hemisphere and Australasian Conference in Hong Kong on 19th-23rd August 1985)
2. Dr. Tsoi Ting Kwok
   The Hypochondriacal Patient
   Vol. 9 No. 7 (1987 March)
   The Hong Kong Practitioner
3. Peter T. K. Tsoi, Robert K. H. Chin and Allan M. Z. Chang
   Psychogenic Factors in Hyperemesis Gravidarum
   Asia-Oceania Journal of Obstetrics and Gynaecology
   Volume 14, Issue 4, pages 457–460, December 1988
4. Peter T.K. Tsoi and T.C. Tan
   A case of inorganic led poisoning presenting with features of a depressive
   illness
   Journal of the Hong Kong Medical Association Vol. 40, No. 3, 1988
5. Dr. Peter T. K. Tsoi
   Grief and Related Problems in General Practice
   Vol. 11 No. 5 (1989 May)
   The Hong Kong Practitioner

• Social cognition and emotion in psychosis
• Facial emotion perception

• Community psychiatry
• Sleep medicine

• Old age psychiatry
• Perinatal mental health
• Adolescent psychiatry
• Creative arts therapy / expressive arts therapy

• Registered Arts Therapist (Expressive Arts) (AThR, ANZACATA)
• Master of Expressive Arts Therapy (MExpArtsTh, HKU) (Distinction)

1. Wong, C.H.Y. (2020)
   The Effect of Expressive Arts Therapy in Dementia-related Apathy in Chinese Older Adults.
   Research Dissertation for MExpArtsTh, Department of Social Work and Social Administration, Faculty of Social Sciences, The University of Hong Kong.
2. Ma, D.Y., Wong, C.H.Y., Leung, G.T.Y., Fung, A.W.T., Chan, W.C., Lam, L.C.W. (2017).
   Physical Exercise Helped to Maintain and Restore Functioning in Chinese Older Adults with Mild Cognitive Impairment: A 5-Year Prospective Study of the Hong Kong Memory and Ageing Prospective Study (HK-MAPS).
   JAMDA 18(4):306-311
3. Wong, C.H.Y., Leung, G.T.Y., Fung, A.W.T., Chan, W.C., & Lam, L.C.W. (2013).
   Cognitive predictors for five-year conversion to dementia in community dwelling Chinese older adults.
   International Psychogeriatrics, 25(7), 1125-1134.
4. Fung, A., Wong, C., & Lam, L. (2012)
   Cognitive activity predicted better cognitive function in community-dwelling elderly Chinese over a five-year period.
   Alzheimer’s & Dementia 8(4 supplement), 139-140.
5. Wong, C.H., Lam, L.C., Lui, V.W., Chiu, H.F., Chan, S.S., & Tam, C.W. (2006).
   Subjective complaints and self-evaluation of memory test performance in Questionable dementia.
   International Journal of Geriatric Psychiatry, 21(10), 937-944.

• Consultation-liaison psychiatry
• General adult psychiatry
• Medical statistics and research methodology

1. Wong KC, Interpretation of correlation coefficients.
   Hong Kong Medical Journal 2010; 16: 237
2. Wong KC, Chi squared test versus Fisher’s exact test.
   Hong Kong Medical Journal 2011; 17: 427
3. Wong KC, Use and Interpretation of Statistical Tests.
   East Asian Arch Psychiatry 2014; 24: 178
4. Wong KC, Study Guide for STAT S242 Statistics in Society, Unit 1 – 8, 2015; The Open University of Hong Kong; Hong Kong.
5. Wong KC, Null Hypothesis Testing (I) – 5% Significance Level.
   East Asian Arch Psychiatry 2016; 26: 112-3

• Mindfulness

• Community and Rehabilitation Psychiatry
• Recovery-Oriented practice

• Psychiatry

• Child and Adolescent Psychiatry

• Child and adolescent mental health
• Psychotherapy

• Adult psychiatry
• Rehabilitative psychiatry
• Genetics in psychiatry

1. Lam, M. H. B., Wing, Y. K., Yu, M. W. M., Leung, C. M., Ma, R. C., Kong, A. P. & Lam, S. P. (2009).
   Mental morbidities and chronic fatigue in severe acute respiratory syndrome survivors: long-term follow-up.
   Archives of internal medicine, 169(22), 2142-2147.
2. Lam, M. H. B., Zhang, J., Li, A. M., & Wing, Y. K. (2011).
   A community study of sleep bruxism in Hong Kong children: association with comorbid sleep disorders and neurobehavioral consequences.
   Sleep medicine, 12(7), 641-645.
3. Rao, S., Leung, C. S. T., Lam, M. H., Wing, Y. K., Waye, M. M. Y., & Tsui, S. K. W. (2017).
   Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.
   Gene, 603, 34-41.
4. Lee, W. K., Yeung, A., Leung, K., Lam, H. B., Wong, C. K., Au, M. K., & Fu, C. K. (2018).
   Consensus statements on the clinical understanding and use of milnacipran in Hong Kong.
   Human Psychopharmacology: Clinical and Experimental. 2018 Mar;33(2):e2651.
5. Rao, S., Siu, C. O., Shi, M., Zhang, J., Lam, M. H. B., Yu, M. & Waye, M. M. Y. (2018).
   Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model.
   Gene, 679, 382-388.

• General adult psychiatry
• Psychiatric consultation-liaison

• General adult psychiatry

• Adult ADHD and ASD
• Common mental disorder

• Training in rTMS: Clinical Transcranial Magnetic Stimulation Certificate at Monash Alfred Psychiatric research centre under Prof. Paul Fitzgerald, in August 2014.
• Training in administering ADOS-2: UCL Institute of Child Health, London, in Jan. 2015
• Training in “EEG Biofeedback”: Comprehensive training course by Neurotherapy Institute of Australia, Melbourne, Australia, in March 2015
• Training in “Mindfulness-based Cognitive Therapy”: Part 1 and Part 2 seed teacher training of Oxford Mindfulness Centre by Prof. Mark Williams, in April 2016

1. VMC Leung, LF Chan.
   A cross-sectional cohort study of prevalence, co-morbidities, and correlates of Attention-deficit Hyperactivity Disorder among Adult patients admitted to the Li Ka Shing Psychiatric Outpatient Clinic, Hong Kong.
   East Asian Arch Psychiatry 2017; 27: 63-70—Principal Investigator

• Psychiatry

• Psychiatry

• Psychiatry

• Community psychiatry

• Child and adolescent psychiatry

• Child and adolescent psychiatry

1. Kwok TT, Chan MM, Mo FY, Hung SF, Leung PW, Lai KY, Shea CK.
   Prevalence of autism in first-episode psychosis in two Hong Kong teaching hospitals.
   Autism. 2024 Jun 13:13623613241259062. doi: 10.1177/13623613241259062. Epub ahead of print. PMID: 38869152.
2. Chan MMY, Choi CXT, Tsoi TCW, Shea CKS, Yiu KWK, Han YMY.
   Effects of multisession cathodal transcranial direct current stimulation with cognitive training on sociocognitive functioning and brain dynamics in autism: A double-blind, sham-controlled, randomized EEG study.
   Brain Stimul.2023 Nov-Dec;16(6):1604-1616. doi: 10.1016/j.brs.2023.10.012. Epub 2023 Nov 2. PMID: 37918630.
3. Li X, Lau FLF, Chiu WV, Wong CKD, Li AM, Wing YK, Lai YCK, Shea KSC, Li SX.
   An Open-Label Pilot Trial of a Brief, Parent-Based Sleep Intervention in Children With ADHD.
   J Atten Disord. 2024 Jun;28(8):1173-1185. doi: 10.1177/10870547241233731. Epub 2024 Mar 5. PMID: 38439703.
4. Leung KK, Wong YC, Shea KS, Chan SC, Chang WC, Mo YMF, Chan SMS.
   Altered neutrophil-to-lymphocyte ratio in patients with non-affective first episode psychosis and its relationship with symptom severity and cognitive impairment.
   Sci Rep. 2023 Jul 15;13(1):11453. doi: 10.1038/s41598-023-37846-y. PMID: 37454218; PMCID: PMC10349799.
5. Han YM, Chan MM, Shea CK, Mo FY, Yiu KW, Chung RC, Cheung MC, Chan AS.
   Effects of prefrontal transcranial direct current stimulation on social functioning in autism spectrum disorder: A randomized clinical trial.
   Autism. 2023 May 8:13623613231169547. doi: 10.1177/13623613231169547. Epub ahead of print. PMID: 37151094.
6. Wong OWH, Lam AMW, Or BPN, Mo FYM, Shea CKS, Lai KYC, Ma SL, Hung SF, Chan S, Kwong TNY, Wong S, Leung PWL.
   Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case-control study on prepubertal Chinese boys.
   Sci Rep. 2022 Jun 23;12(1):10659. doi: 10.1038/s41598-022-14785-8. PMID: 35739175; PMCID: PMC9225987.
7. Li X, Shea KSC, Chiu WV, Lau FLF, Wong CKD, Yu WMM, Li AM, Wing YK, Lai YCK, Li SX.
   The associations of insomnia symptoms with daytime behavior and cognitive functioning in children with attention-deficit/hyperactivity disorder.
   J Clin Sleep Med. 2022 Aug 1;18(8):2029- 2039.
8. Han YMY, Chan MMY, Shea CKS, Lai OL, Krishnamurthy K, Cheung MC, Chan AS.
   Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study.
   Brain Stimul.2022 Mar-Apr;15(2):414-425.
9. Ma SL, Chen LH, Lee CC, Lai KYC, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL.
   Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2Gene.
   Front Neurosci. 2021 Apr 27;15:649588. doi: 10.3389/fnins.2021.649588. PMID: 33986640; PMCID: PMC8111170.
10. Li X, Shea KSC, Wong C.K.D., Chiu W.V., Lau L.F., Yu M.W.M., Li A.M., Lai Y.C.K., Li S.X. (2021).
    The association of circadian rhythms and cognitive functioning in children with attention- deficit hyperactivity disorder.
    Sleep, 44(S2), A245.
11. Li X., Shea KSC, Chiu W.V., Lau L.F., Wong C.K.D., Yu M.W.M., Li A.M., Wing Y.K., Lai Y.C.K., Li S.X. (2020).
    Insomnia and behavioural and cognitive functioning in children with attention deficit hyperactivity disorder – a case-control study.
    Journal of Sleep Research, 29(S1), P88.
12. Li S.X., Lau L.F., Chiu W.V., Wing Y.K., Li A.M., Lai Y.C.K., Shea KSC (2019).
    Effects of a brief parent-based sleep intervention on sleep and clinical symptoms in children with attention deficit hyperactivity disorder, and parental sleep and mental health.
    Sleep, 42(supplement 1), A301.
13. Lai KYC, Leung PWL, Hung SF, Shea CKS, Mo F, Che KKI, Tse CY, Lau FLF, Ma SL, Wu JCY, So S, Dadds MR.
    Gastrointestinal Problems in Chinese Children with Autism Spectrum Disorder.
    Neuropsychiatr Dis Treat. 2020;16:1807-1815.
14. Shea CKS, Lee MMC, Lai KYC, Luk ESL, Leung PWL.
    Prevalence of Anxiety Disorders in Hong Kong Chinese Children With ADHD.
    J Atten Disord. 2018;22(5):403-413. Caroline KS Shea, MBChB, FHKCPsych, FHKAM(Psychiatry)
15. Tsui KW, Lai KY, Lee MM, Shea CK, Tong LC.
    Prevalence of motor problems in children with attention deficit hyperactivity disorder in Hong Kong.
    Hong Kong Med J. 2016;22(2):98-105.
16. Lai KY, Leung PW, Mo FY, Lee MM, Shea CK, Chan GF, Che KK, Luk ES, Mak AD, Warrington R, Skuse D.
    Validation of the Developmental, Dimensional and Diagnostic Interview (3Di) Among Chinese Children in a Child Psychiatry Clinic in Hong Kong.
    J Autism Dev Disord. 2015;45(5):1230-7.
17. Shea CK.
    Book Review: Elimination Disorders in Children and Adolescents (Advances in Psychotherapy – Evidence-based Practice).
    East Asian Arch Psychiatry. 2011;21:37.

1. Health and Medical Research Fund (HMRF) 2023,
   “Cumulative and booster effects of multisession prefrontal transcranial direct-current stimulation on cognitive and social impairments in adolescents with autism spectrum disorder” (Co-I) (HKD 1,500,000 2023-2026)
2. General Research Fund (GRF) 2022,
   “Effects of cognitive behavioral therapy and bring light therapy in youth with unipolar depression and evening chronotype: An assessor-blind, parallel- group, randomized controlled trial” (Co-I) (HKD 924,788 2022-2023)
3. General Research Fund (GRF) 2022,
   “A machine learning approach for predicting tDCS treatment outcomes of adolescents with autism spectrum disorders” (Co-I) (HKD 1,333,647 2022- 2023)
4. General Research Fund (GRF) 2021,
   “Efficacy of group cognitive behavioral therapy for youth anxiety and insomnia: A randomized, assessor blind, parallel-group trial” (Co-I) (HKD 725,064 2021-2022)
5. Health Care and Promotion Fund (HCPF) 2017,
   “A brief parent-based intervention to improve sleep for children with attention deficit hyperactivity disorder” (Co-I) (HKD 291,548 2017- 2019)
6. Health and Medical Research Fund (HMRF) 2015,
   “Illuminating the functional abnormalities of brain networks underlying social communication and repetitive behaviors in Autism Spectrum Disorder (ASD): Implication on a neurobiological treatment of neurofeedback” (Co-I) (HKD 754,538 2015-2018)

• General adult psychiatry
• Neuromodulation

• Child & adolescent psychiatry
• Adult psychiatry

• Child and adolescent psychiatry
• Psychiatry of learning disability

• Child and adolescent psychiatry
• Social and rehabilitation psychiatry

• Dual diagnosis
• Addiction psychiatry
• Motivational interviewing

• Certified Trainer, Motivational Interviewing Network of Trainers (MINT)
• Senior Addiction Counselor, Asia Pacific Certification Commission for Addiction Professional (APCCAP)

• Psychiatry

• General adult psychiatry
• Community psychiatry
• Medical psychotherapy

• Hong Kong College of Psychiatrists Prize (2013)
• Wong Ching Yee Medical Award (2013)
• Distinction in Psychiatry, Final MBBS Examination (2013)

• Psychiatry

• Consultation liaison psychiatry

1. Wong, K. M. F., Yuen, S. S. Y., & Mak, A. D. P. (2019).
   Neurocognitive characteristics of individuals with irritable bowel syndrome.
   East Asian Archives of Psychiatry, 29(2), 48-56.
2. Wong, K. M. F., Mak, A. D. P., Yuen, S. Y., Leung, O. N. W., Ma, D. Y., Chan, Y., … & Wu, J. C. Y. (2019).
   Nature and specificity of altered cognitive functioning in IBS.
   Neurogastroenterology & Motility, e13696.

• Child and adolescent psychiatry

• Psychiatry

• Psychiatry
• Consultation Liaison Psychiatry
• Psychosomatic medicine
• Eating disorders

• Consultation liaison psychiatry
• Child and adolescent psychiatry
• General Adult psychiatry

• Psychiatry

• Psychiatry

B.Sc. (Human Biology) 2006; Ph.D. (Physiology) 2010; M.B.Ch.B. 2015; FHKCPsych, FHKAM (Psychiatry) 2022

Distinguished young fellow (Psychiatry), the Hong Kong Academy of Medicine, 2023

– Early Assessment Service for Young People with Early Psychosis
– Pathophysiology of Psychosis
– Diabetes and Stem Cell Biology

1. Leung KK, Wong YC, Shea KS, Chan SC, Chang WC, Mo YMF, Chan SMS. (2023)
   Altered neutrophil-to-lymphocyte ratio in patients with non-affective first episode psychosis and its relationship with symptom severity and cognitive impairment.
   Sci Rep. 13(1):11453.
2. Leung KK, Liang J, Zhao S, Chan WY, Leung PS. (2014)
   Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos.
   Dev Dyn. 243(3): 415-427.
3. Liang J, Leung KK, Lam SY, Leung PS. (2012)
   Combined treatment with a dipeptidyl peptidase-IV inhibitor (sitagliptin) and an angiotensin II type 1 receptor blocker (losartan) promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells.
   Diabetes Obes Metab. 14(9): 842-851.
4. Leung KK, Liang J, Ma MT, Leung PS. (2012)
   Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation.
   Stem Cells. 30(3): 525-536.
5. Leung KK, Suen PM, Lau TK, Ko WH, Yao KM, Leung PS. (2009)
   PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization.
   Stem Cells Dev. 18(7): 979-990.

• Psychiatry

• Substance abuse
• Adult psychiatry

• Senior trainee under the Hong Kong College of Psychiatrists

1. Poon JY, Leung CM.
   Outcome of first-episode acute and transient psychotic disorder in Hong Kong Chinese: a 20-year retrospective follow-up study.
   Nord J Psychiatry. 2017 Feb;71(2):139-144.
2. Heung J, Poon JY, Tung CK, Yeung SW, Lam M.
   Confusion in Sobriety: A Case Study on Disulfiram Encephalopathy in a Middle-Aged Male Patient.
   Alcohol Alcohol. 2018 Jul 1;53(4):497-498.

• Old age psychiatry

1. Pan IMY, Lau MS, Mak SC, Hariman KW, Hon SKM, Ching WK, Cheng KM, Chan CF.
   Staging of Dementia Severity With the Hong Kong Version of the Montreal Cognitive Assessment (HK-MoCA)’s.
   Alzheimer Dis Assoc Disord. Oct-Dec 2020;34(4):333-338.
2. Pan I, Selinger CP, Pritchard S, Ramesh J.
   Eosinophilic gastritis with idiopathic thrombocytopaenic purpura: coincidence or association?
   Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1425-7

• Psychiatry
• Sleep medicine

• Child and adolescent psychiatry

• Clinical work
• Rehabilitation service
• Psychotherapy