RESEARCH TOPICS

Our group has conducted a series of studies on behavioural, biomarker, and neuropsychological research in neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) in children. Our findings highlight the psychiatric and physical comorbidities that are highly prevalent among children with neurodevelopmental disorders. We have also validated various instruments that have been used for assessing autism and ADHD in western countries. The Chinese versions of these instruments are now being widely used in Hong Kong. Another vein of aetiological exploration into the microbiome signature of ASD is underway to elucidate the pathomechanism at gut-brain interface that may offer an avenue for early detection and early intervention. In parallel, we are using advanced tools in systems neuroscience and computational psychiatry to investigate the cellular circuits involved in the microbiome-gut-brain axis. This work aims to build evidence to improve neuropathology classification and identify specific therapeutic targets. To improve intervention, a multi-modal neurophysiological biomarker for autism spectrum disorder (ASD) and neurofeedback training is in development. This innovative approach aims to integrate various brain imaging and physiological signals to enhance our understanding of ASD and provide individualized interventions through targeted neurofeedback techniques. Another double-blind randomized controlled trial on the effectiveness, tolerability and feasibility of transcranial direct current stimulation is underway for pre-pubertal ASD children with comorbid ADHD.