People

• Officer of the Most Excellent Order of the British Empire (OBE) – Appointed by Her Majesty, The Queen of The United Kingdom
• Honorary Fellow (2008), Shaw College, CUHK
• International Distinguished Fellow (since 2012), American Psychiatric Association
• Honorary Fellow (2014), Hong Kong College of Psychiatrists
• Special Contribution Award, Chinese Sleep Research Society
• Emeritus Professorship in 2018

Adjunct Assistant Professor (non-Clinical)

• Epidemiology and genetic epidemiology of sleep disorders
• Pathogenesis of insomnia disorder
• Mechanisms underlying the close associations of mood disorders with sleep disorders and circadian rhythms

• Circadian Rhythms dysregulation in the unaffected adolescent offspring of parents with bipolar I disorder
  躁鬱症患者的青少年子女晝夜節律失調研究
• Familial aggregation and biomarkers of REM sleep behavior disorder: a case-control family study
  快速眼動睡眠行為障礙的遺傳及生物標志物對照研究

1. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X. Response to commentary by Heidari and Arabzadeh on “Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis”. Sleep Med Rev. 2019 Aug;46:162-163.
2. Lim LL, Tse G, Choi KC, Zhang J, Luk AOY, Chow E, Ma RCW, Chan MHM, Wing YK, Kong APS, Chan JCN. Temporal changes in obesity and sleep habits in Hong Kong Chinese school children: a prospective study. Sci Rep. 2019 Apr 10;9(1):5881.
3. Liu Y, Zhang J, Lam SP, Yu MWM, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan A, Mok V, Wing YK. Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study. Sleep Med. 2019 Apr;56:128-134.
4. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis. Sleep Med Rev. 2019 Jun;45:1-17.
5. Merikangas KR, Swendsen J, Hickie IB, Cui L, Shou H, Merikangas AK, Zhang J, Lamers F, Crainiceanu C, Volkow ND, Zipunnikov V. Real-time Mobile Monitoring of the Dynamic Associations Among Motor Activity, Energy, Mood, and Sleep in Adults With Bipolar Disorder. JAMA Psychiatry. 2018 Dec 12.
6. Wang F, Zhang L, Wu S, Li W, Sun M, Feng W, Ding D, Yeung-Shan Wong S, Zhu P, Evans GJ, Wing YK, Zhang J, Vlaanderen JJ, Vermeulen RCH, Zhang Y, Chan EY, Li Z, Tse LA. Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator? Occup Environ Med. 2019 Feb;76(2):83-89.
7. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK. Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects. Sleep Med. 2019 Jan;53:1-8.
8. Rao S, Siu CO, Shi M, Zhang J, Lam MHB, Yu M, Wing YK, Waye MMY. Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model. Gene. 2018 Dec 30;679:382-388.
9. Suh S, Cho N, Zhang J. Sex Differences in Insomnia: from Epidemiology and Etiology to Intervention. Curr Psychiatry Rep. 2018 Aug 9;20(9):69.
10. Zhang J, Lam SP, Li SX, Liu Y, Chan JWY, Chan MHM, Ho CS, Li AM, Wing YK. Parental history of depression and higher basal salivary cortisol in unaffected child and adolescent offspring. J Affect Disord. 2018 Jul;234:207-213.

Dr. Lam graduated from The Chinese University of Hong Kong. She is currently a Honorary Clinical Assistant Professor in CUHK. She has been working in Department of Psychiatry, Prince of Wales Hospital and Shatin Hospital for more than 14 years. Her research interests focus on clinical epidemiological study on sleep disorders and drug trials.

Mr. Ho joined CUHK in 1986 and assisted in setting up the first local dedicated sleep laboratory, and contributed in the formation of Hong Kong Society of Sleep Medicine (HKSSM). He is the first sleep technician in South East Asia who obtained the RPSGT designation. He has ample experience in the investigation and management of various sleep disorders from children to elderly, and education and development of sleep medicine in both Hong Kong and China. He actively participated in clinical sleep researches in the department. He is the first and current chairperson of the RPSGT Committee of HKSSM, and honorary consultant in sleep technology of both the Chinese Medical Doctors Association and the Chinese Sleep Research Society.

Assistant Professor (non-clinical)

• Dr. Liu received his clinical education at Southern Medical University, where he earned his bachelor’s degree in clinical medicine. After receiving his master’s degree in clinical medicine from Jinan University, he became a psychiatrist at the First Affiliated Hospital of Jinan University. He then pursued his PhD at the Chinese University of Hong Kong. He also did a two-year postdoctoral fellowship in the Department of Psychiatry at the Chinese University of Hong Kong and another two-year visiting postdoctoral fellowship in the Nuffield Department of Clinical Neuroscience at the University of Oxford. He is currently an Assistant Professor in our department. His research interests focus on identifying neurodegenerative biomarkers in REM sleep behavior disorders and developing potential neuroprotective interventions in REM sleep behavior disorders.

• Genetic epidemiology of sleep disorders especially on REM sleep behavioral disorder
• The biomarker of neurodegenerative diseases in REM sleep behavioral disorder

• Director of Sleep Assessment Unit
• Professor (Clinical) & Chairman, Department of Psychiatry
• Deputy Director of Centre for Clinical Trials on Chinese Medicine

• Sleep medicine
• Biological and cultural psychiatry
• Neuropsychiatry
• Transcultural psychopharmacology

• Striatal dopamine transmission in individuals with isolated rapid eye movement sleep without atonia: a search for precursor biomarker for neurodegeneration
  孤立性快速眼動睡眠肌張力失弛緩的多巴胺轉運：尋找神經退化的生物學標記
• Gut microbiota across early stages of synucleinopathy: from high-risk relatives, REM sleep behavior disorder to early Parkinson’s disease
  早期突觸核蛋白變性疾病與腸道微生物：從高危親屬、快速眼動睡眠行為障礙到早期帕金遜
• Adjunctive light treatment in major depressive disorder among evening chronotype – A randomized controlled trial
  聯合光治療對夜晚型抑鬱症患者的療效：一個隨機對照研究
• Prodromal markers of synucelinopathy neurodegeneration in the first degree relatives of patients with psychiatric disorders comorbid with REM sleep behavior disorder
  突觸核蛋白變性相關神經退化的早期標記與精神障礙伴有快速眼動睡眠行為障礙的一級親屬的關係
• Can we prevent insomnia? A randomized controlled trial of brief cognitive behavioral Insomnia prevention program for high-risk adolescents
  我們是否可以預防失眠？一個針對高危青少年的認知行為治療隨機對照臨床試驗

1. Rao S, Siu CO, Shi M, Zhang J, Lam MHB, Yu M, Wing YK, Waye MMY.
   Associations of Homer Scaffolding Protein 1 gene and psychological correlates with suicide attempts in Chinese: A pilot study of multifactorial risk model.
   Gene. 2018 Dec 30;679:382-388.
2. Liu S, Wing YK, Hao Y, Li W, Zhang J, Zhang B.
   The associations of long-time mobile phone use with sleep disturbances and mental distress in technical college students: a prospective cohort study.
   Sleep. 2018 Nov 3.
3. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Med. 2018 Sep 24;53:1-8.
4. Rao S, Han X, Shi M, Siu CO, Waye MMY, Liu G, Wing YK.
   Associations of the serotonin transporter promoter polymorphism (5-HTTLPR) with bipolar disorder and treatment response: A systematic review and meta-analysis.
   Prog Neuropsychopharmacol Biol Psychiatry. 2018 Sep 11;89:214-226.
5. Ren R, Covassin N, Yang L, Li Y, Zhang Y, Zhou J, Tan L, Li T, Li X, Wang Y, Zhang J, Wing YK, Li W, Somers VK, Tang X.
   Objective but Not Subjective Short Sleep Duration Is Associated With Hypertension in Obstructive Sleep Apnea.
   Hypertension. 2018 Sep;72(3):610-617.
6. Li SX, Chan NY, Man Yu MW, Lam SP, Zhang J, Yan Chan JW, Li AM, Wing YK.
   Eveningness chronotype, insomnia symptoms, and emotional and behavioural problems in adolescents.
   Sleep Med. 2018 Jul;47:93-99.
7. Zhang J, Lam SP, Li SX, Liu Y, Chan JWY, Chan MHM, Ho CS, Li AM, Wing YK.
   Parental history of depression and higher basal salivary cortisol in unaffected child and adolescent offspring.
   J Affect Disord. 2018 Jul;234:207-213.
8. Zhou J, Zhang J, Lam SP, Chan JW, Mok V, Chan A, Li SX, Liu Y, Tang X, Yung WH, Wing YK.
   Excessive Daytime Sleepiness Predicts Neurodegeneration in Idiopathic REM Sleep Behavior Disorder.
   Sleep. 2017 May 1;40(5).
9. Li SX, Lam SP, Zhang J, Yu MW, Chan JW, Liu Y, Lam VK, Ho CK, Zhou J, Wing YK.
   A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder.
   Sleep Med. 2016 May;21:114-20.
10. Zhou J, Zhang J, Lam SP, Mok V, Chan A, Li SX, Liu Y, Tang X, Yung WH, Wing YK.
    Mortality and Its Risk Factors in Patients with Rapid Eye Movement Sleep Behavior Disorder.
    Sleep. 2016 Aug 1;39(8):1543-50.

Associate Professor (Clinical)

• General adult psychiatry
• Circadian medicine
• Sleep medicine

1. Tang JH, Wing YK, Chan JWY*, Lo RSK. Bright Light Therapy for Cancer-related Fatigue in a Palliative Care Unit: A Feasibility Study. J Pain Symptom Manage. 2023;65(3):e237-e40.
2. Feng H, Yang L, Liang YY, Ai S, Liu Y, Liu Y, et al. Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study. Nat Commun. 2023;14(1):930.
3. Chan JWY*, Chan NY, Li SX, Lam SP, Chau SWH, Liu Y, et al. Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference. J Clin Sleep Med. 2022;18(2):523-31.
4. Chan JWY*, Li SX, Chau SWH, Chan NY, Zhang J, Wing YK. Prediction of Dropout in a Randomized Controlled Trial of Adjunctive Light Treatment in Patients with Non-Seasonal Depression and Evening Chronotype. Clocks Sleep. 2022;4(3):346-57.
5. Chan JW, Lam SP, Li SX, Chau SW, Chan SY, Chan NY, et al. Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial. Psychol Med. 2022;52(8):1448-57.
6. Chan JW, Lam SP, Li SX, Yu MW, Chan NY, Zhang J, et al. Eveningness and insomnia: independent risk factors of nonremission in major depressive disorder. Sleep. 2014;37(5):911-7.

Assistant Professor (Clinical)

My research interests lie in the complex interactions between mental health and neurodegeneration. The two categories have traditionally been investigated separately, but emerging evidence suggests that they are closely linked. My research explores (i) the potential of neuropsychiatric phenomena and subtle alterations of cognitive processes as prognostic biomarkers of early-stage neurodegeneration using the model of REM sleep behaviour disorder and (ii) how mental disorders affect neurodegenerative risk. I employ multidisciplinary approaches and methods in my research, with a special focus on model-driven computational analysis using multimodal neuroimaging, molecular and microbiological data.

1. Chan JW, Lam SP, Li SX, Chau SW, Chan SY, Chan NY, Zhang JH, Wing YK. Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial. Psychol Med. 2020 Sep 14:1-10.
2. Feng H, Chen L, Liu, Y, Chen, X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen, J, Mok VC, Wing YK and Zhang J. Rest‐activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder. Ann Neurol. 2020 Sept
3. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JWY, Li SX, Huang B, Feng H, Mok V, Wing YK. Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study. Mov Disord. 2020 Aug.
4. Chau SWH, Lewis T, Ng R, Farrell SM, Molodynski A, Bhugra D. Wellbeing and mental health amongst medical students from Hong Kong. Int Rev Psychiatry. 2019 Nov – Dec;31(7-8):626-629
5. Molodynski A, Lewis T, Kadhum M, Farrell SM, Chelieh ML, De Almeida TF, Masri R, Kar A, Volpe U, Moir F, Torales J, Castaldelli-Maia JM, Chau SWH, Wilkes C, Bhugra D. Cultural variations in wellbeing, burnout and substance use amongst medical students in twelve countries. Int Rev Psychiatry. 2020 Mar 18;1-6.
6. Chau SW, Tse CY, So SH, Chan SS. A Randomised Controlled Study on the Efficacy of Attentional Bias Modification Training (ABMT) in Patients with Generalised Anxiety Disorder (GAD). East Asian Arch Psychiatry. 2019 Mar 29(1):3-9.
7. Lam MH, Chau SW, Wing YK. High prevalence of hypokalemia in acute psychiatric inpatients. General Hospital Psychiatry. 2009 May-June 31(3), 262–265Lam MH, Chau SW, Wing YK. High prevalence of hypokalemia in acute psychiatric inpatients. General Hospital Psychiatry. 2009 May-June 31(3), 262–265.

Assistant Professor

Pediatric sleep and psychopathology
Treatment and prevention of sleep disorders
Digital mental health

• Advancing Adolescent Bedtime by Using Motivational Interviewing and Text Reminders – A Randomized Controlled Trial. (Health and Medical Research Fund, 15163071, 2018 – 2021, as PI)

• Travel Grant Award for Young Investigators in 2nd Congress of Asian Society of Sleep Medicine, Seoul, Korea, 2018

1. Wang G, Zhang J, Lam SP, Li SX, Jiang Y, Sun W, Chan NY, Kong APS, Zhang Y, Li S, Li AM, Jiang F, Shen X, Wing YK. Ten-Year Secular Trends in Sleep/Wake Patterns in Shanghai and Hong Kong School-Aged Children: A Tale of Two Cities. Journal of Clinical Sleep Medicine. 2019;15:1495-502.
2. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK. Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects. Sleep Medicine. 2019; 53: 1-8.
3. Li SX, Chan NY, Man Yu MW, Lam SP, Zhang J, Yan Chan JW, Li AM, Wing YK. Eveningness chronotype, insomnia symptoms, and emotional and behavioural problems in adolescents. Sleep Medicine. 2018; 47: 93-9
4. Lufi D. Wing YK, Chan NY. Assessment of attention level among Chinese and Israeli adolescents. Journal of Behavioral Health.2017; 6: 52-7.
5. Chan NY, Zhang J, Yu MWM, Lam SP, Li SX, Kong APS, Li AM, Wing YK. Impact of a modest delay in school start time in Hong Kong school adolescents. Sleep Medicine. 2017; 30: 164-70
6. Liu Y, Zhang J, Lam SP, Yu MWM, Li SX, Zhou J, Chan JW, Chan NY, Li AM, Wing YK. Help-seeking behaviors for insomnia in Hong Kong Chinese-a community-based study. Sleep Medicine. 2016; 21:106-13.
7. Zhang J, Chan NY, Lam SP, Li SX, Liu Y, Chan JW, Kong AP, Ma RC, Chan KC, Li AM, Wing YK. Emergence of Sex Differences in Insomnia Symptoms in Adolescents: A Large-Scale School-Based Study. Sleep. 2015; 39: 1563-70.
8. Chan NY, Lam SP, Zhang J, Yu MWM, Li SX, Li AM, & Wing YK. Sleep education in Hong Kong. Sleep Biological Rhythm. 2015; 14: 21-5.
9. Wing YK, Chan NY, Yu MWM, Lam SP, Zhang J, Li SX, Kong AP, Li AM. A school-based sleep education program for adolescents: a cluster randomized trial. Pediatrics. 2015; 13: e635-43.
10. Chan JW, Lam SP, Li SX, Yu MW, Chan NY, Zhang J, Wing YK. Eveningness and insomnia: independent risk factors of nonremission in major depressive disorder. Sleep. 2014; 37: 911-7.

Fax: (852) 2647-5321

Email: manholi@cuhk.edu.hk

ORCID: 0000-0002-6328-0105

Google Scholar: vw2vQFQAAAAJ

• Artificial intelligence and digital mental health
• Natural language processing for mental health
• Technology, electronics, and mental health
• Social withdrawal and psychological well-being

1. PI, General Research Fund, Efficacy of Digital Cognitive Behavioral Therapy for Insomnia (CBT-I) with Artificial Intelligence Chatbot for Youth with Insomnia: An Assessor-blind, Randomized Controlled Trial (Ref. no.: 14106223), Research Grants Council, HK$1,148,000, 01/01/2024 – 30/06/2026
2. PI, Direct Grant for Research, Development of Automated Speech-based Suicidal Ideation Detection with Artificial Intelligence Techniques (Ref. no.: 2022.073), CUHK – Research Committee, HK$150,000, 30/06/2023 – 29/06/2024
3. PI, Direct Grant for Research, Identifying Suicide Risk using Natural Language Processing and Machine Learning of Clinical Interviews of Depression (Ref. no.: 2021.055), CUHK – Research Committee, HK$150,000, 29/06/2022 – 28/12/2023
4. PI, Knowledge Transfer Project Fund, An Artificial Intelligence Chatbot for Sleep Education (Ref. no.: KPF22GWP14), The Chinese University of Hong Kong, HK$395,380, 01/04/2022 – 31/03/2024

1. Li, T. M. H., Chan, N. Y., Li, C. T., Chen, J., Chan, J. W., Liu, Y., Li, S. X., Li, A. M., Zhang, J., & Wing, Y. K. (2022). The associations of electronic media use with sleep and circadian problems, social, emotional and behavioral difficulties in adolescents. Frontiers in Psychiatry, 13, 892583.
2. Li, T. M. H., & Leung, C. S. Y. (2020). Exploring student mental health and intention to use online counselling in Hong Kong during the COVID-19 pandemic. Psychiatry and Clinical Neurosciences, 74(10), 564-565.
3. Chau, M., Li, T. M. H., Wong, P. W. C., Xu, J., Yip, P. S. F., & Chen, H. (2020). Finding people with emotional distress in online social media: A design combining machine learning and rule-based classification. Management Information Systems Quarterly, 44(2), 933-955.
4. Liu, L. L., Li, T. M. H., Teo, A. R., Kato, T. A., & Wong, P. W. C. (2018). Harnessing social media to explore youth social withdrawal in three major cities in China: Cross-sectional web survey. JMIR Mental Health, 5(2), e34.
5. Chan, M., Li, T. M. H., Law, Y. W., Wong, P. W. C., Chau, M., Cheng, C., Fu, K. W., Bacon-Shone, J., Cheng, Q., & Yip, P. S. F. (2017). Engagement of vulnerable youths using internet platform. PLoS ONE, 12(12), e0189023.
6. Cheng, Q., Li, T. M. H., Kwok, C. L., Zhu, T., & Yip, P. S. F. (2017). Assessing suicide risk and emotional distress in Chinese social media: A text mining and machine learning study. Journal of Medical Internet Research, 19(7), e243.
7. Ip, P., Chim, D., Chan, K. L., Li, T. M. H., Ho, F. K. W., Van Voorhees, B. W., Tiwari A., Tsang, A., Chan, C. W. L., Ho, M., Tso, W., & Wong, W. H. S. (2016). Effectiveness of a culturally attuned Internet-based depression prevention program for Chinese adolescents: A randomized controlled trial. Depression and Anxiety, 33(12), 1123-1131.
8. Li, T. M. H., & Wong, P. W. C. (2015). Youth social withdrawal behavior (hikikomori): A systematic review of qualitative and quantitative studies. Australian and New Zealand Journal of Psychiatry, 49(7), 595-609.
9. Li, T. M. H., Chau, M., Yip, P. S. F., & Wong, P. W. C. (2014). Temporal and computerized psycholinguistic analysis of the blog of a Chinese adolescent suicide. Crisis: The Journal of Crisis Intervention and Suicide Prevention, 35(3), 168-175.
10. Li, T. M. H., Chau, M., Wong, P. W. C., Lai, E. S. Y., & Yip, P. S. F. (2013). Evaluation of a web-based social network electronic game in enhancing mental health literacy for young people. Journal of Medical Internet Research, 15(5), e80.

PhD (CUHK)

Dr. Lam graduated from the faculty of medicine of The Chinese University of Hong Kong. He received psychiatric training from Kwai Chung Hospital, Queen Mary Hospital, Alice Ho Miu Ling Nethersole Hospital and Shatin Hospital. He is a member of The Royal College of Psychiatrists and a fellow of The Hong Kong College of Psychiatrists and The Hong Kong Academy of Medicine. Currently Dr. Lam is working as an Associate Consultant in psychiatry department of Prince of Wales Hospital and Shatin Hospital. He also serves as Honorary Assistant Clinical Professor of the psychiatry department of The Chinese University of Hong Kong. His research focus is on mood and sleep disorders and he has published over ten papers covering topics related to mood disorder, sleep disorder genetics and psychiatric medications.

Ms. Lam is a registered nurse, registered polysmnographic sleep technologist (RPSGT) and has received her credential in Clinical Sleep Health (CCSH). She has given various contributions to sleep study in research, regularly involved in various workshops, seminars and training course, and has co-authored and authored several research papers and journal articles. She holds a Bachelor of Nursing from the University of Monash, Australia and Master of Nursing (Clinical Leadership) from the University of Western Sydney, Australia. Moreover, she is an advanced practice nurse in Sleep Assessment Unit of Shatin Hospital, a Secretary of Registered Polysomnographic Technologists Committee (RPSGTC) Hong Kong Society of Sleep Medicine.

Research Assistant

Leo graduated from The Univerisity of Lancaster, United Kingdom and currently work as a research assistant in the unit. He is involved in the studies related to light therapy for eveningness people and also REM sleep behavior disorders among psychiatric population.

Nurse

Jessie received her bachelor’s degree in Adult Nursing from Queen’s University of Belfast, UK and Master degree in Nursing from the Chinese University of Hong Kong. She worked as an orthopedic nurse in UK for several years prior to join the Team. She is currently working with the elderly population and also involved in different RBD related projects.

Research Associate

Mandy currently is the Research Associate in the Department of Psychiatry, The Chinese University of Hong Kong. She obtained the Bachelor degree of Food & Nutrition in Business & Industry with University Honor Roll from the Texas Woman’s University in the United States of America and Master of Public Health from the Chinese University in Hong Kong. Mandy is also the registered Polysomnographic Technologists (RPSGT) in the Board of Registered Polysomnographic Technologists, United States since 2001.

Dr. Chen Sijing is currently a postdoctoral fellow at The Chinese University of Hong Kong. She received her bachelor’s degree from Qiqihar Medical University and Master of Science in Biological Psychiatry from Peking University. She obtained the qualification of Licensed Physician in Mainland China during her master’s study. Then she obtained her Ph.D. diploma in The Chinese University of Hong Kong. Her Ph.D. research project is designed to investigate the effect of e-CBT-I on improving insomnia in order to prevent depression in youth. Her research interest is in exploring the associations of sleep disturbances with psychiatric disorders, neurodegenerative diseases, and physical disorders.

• Longitudinal follow-up of impulsivity across early stages of α-synucleinopathy
• A 7-year follow-up of REM sleep behavior disorder

Dr. Jie Chen obtained bachelor’s degree and master’s degree from Shanghai Jiaotong University. Then he received PhD’s degree from the Chinese University of Hong Kong. Now he is a postdoctoral fellow at the Department of Psychiatry in Chinese University of Hong Kong. His research interest currently focuses on digital phenotyping in clinical assessment of depression.

Dr Suyi Xie received her PhD in Medical Science at the Chinese University of Hong Kong in 2021. She got a degree of Master of Science in Nutrition and Health in Wageningen University & Research, the Netherlands. Her research focuses on the roles of circadian misalignment (i.e., unfavourable sleep and eating habits) gut microbiota on individuals with metabolic diseases via bioinformatics and epidemiologic methodology.

Dr. Chris Xie Chen is currently a postdoctoral fellow at The Chinese University of Hong Kong. She received her bachelor’s degree in Clinical Medicine and her master’s degree in Psychiatry at Shantou University. She also received the standardized residency training in Department of Psychiatry in Guangdong Provincial People’s Hospital and obtained qualification of psychiatrist in Mainland China. Then she received her PhD’s degree in Medical Sciences at the Chinese University of Hong Kong. Her PhD research project focused on exploring the role of sleep and circadian rhythm in mental resilience. Her postdoctoral work keeps focusing on sleep and circadian rhythm and mental health in adolescents and adults.

Research Assistant

Timothy obtained his bachelor’s degree from Cornell University in the United States, majoring in cognitive science and psychology with a minor in computer science. He is currently studying a Master of Social Sciences (Counselling) at HKU. His interests include adult psychopathology, psychotherapy as well as computational modeling and machine learning.

Papara obtained her bachelor’s degree from the University of Hong Kong, majoring in Psychology and minoring in Counseling. Her interests include psychotherapy, body-mind-spirit connection and brain health.

Research Assistant

Research Assistant

Janet obtained her master’s degree in Psychology from the University of Hong Kong in 2022. She worked as a management trainee in a conglomerate in Hong Kong after obtaining her bachelor’s degree in BBA Management in 2019. Her interests include psychotherapy, mental wellness, child development as well as employee’s well-being and motivation.

Research Assistant

Alice worked as a teacher in a primary school after obtaining her bachelor’s degree in Language Education in HKU. She obtained her first master’s degree in Educational Leadership and Administration from CUHK, and currently studying her second master’s degree in Psychology. Her interests include mental wellness, family therapy, child development, as well as institutional and organizational psychology. 

Research Assistant

B.S.Sc. in Psychology, The Chinese University of Hong Kong

M.Phil. in Psychology, The Chinese University of Hong Kong

M.S.Sc. in Clinical Psychology, The Chinese University of Hong Kong

Ms. Fu is currently working as a clinical psychologist for the Jockey Club SleepWell Project. Prior to joining this team, she worked on several digital projects aimed at promoting mental health, preventing mental illness, and providing early intervention for individuals experiencing mental health distress. Ms. Fu‘s research interests include studying the effectiveness of digital interventions, developing personalized wellness programs for individuals, and identifying factors that impact the wellness of marginalized groups in society.

IT Manager

Research Assistant

Research Assistant

Before Joining the department of Psychiatry at the Chinese University of Hong Kong (CUHK) in 2021, Pinle received his master’s degree in epidemiology from the Imperial College London, bachelor’s degree in Preventive medicine from Guangzhou Medical University, and a joint bachelor’s degree in public health from the University of Wolverhampton. Now he is supervised by professor Wing yun kwok, and co-supervised by Dr. Liu yaping and Dr. CHAN Ngan Yin Rachel. His PhD Project focuses on the Novel Digital mental health (DMH) platform for early detection and intervention of long-term neuropsychiatric sequelae and association with gut dysbiosis.

PhD student


Tel: (852) 3919-7449
Email: shitang@link.cuhk.edu.hk

• The ISMRM Magna Cum Laude Merit Award, 2020, Sydney, Australia

• Brain signatures in psychiatric/neurodegenerative diseases
• Neuropathophysiology and brain-behavior associations of REM sleep behavior disorder

• Multimodal brain connectomics markers of idiopathic REM sleep behavior disorder and their prediction towards α-synucleinopathy

1. Tang S, Wang Y, Liu Y, Chau SW, Chan JW, Chu WC, et al. Large-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity. EBioMedicine. 2022;77:103915
2. Wang Y, Tang S, Ma R, Zamit I, Wei Y, Pan Y. Multi-modal intermediate integrative methods in neuropsychiatric disorders: A review. Comput Struct Biotechnol J. 2022;20:6149-62.
3. Wang Y, Tang S, Zhang L, Bu X, Lu L, Li H, et al. Data-driven clustering differentiates subtypes of major depressive disorder with distinct brain connectivity and symptom features. The British Journal of Psychiatry. 2021;219(5):606-13.
4. Tang S, Li H, Lu L, Wang Y, Zhang L, Hu X, et al. Anomalous functional connectivity of amygdala subregional networks in major depressive disorder. Depression and Anxiety. 2019;36(8):712-22.
5. Tang S, Lu L, Zhang L, Hu X, Bu X, Li H, et al. Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis. EBioMedicine. 2018;36:436-45.

• Gut microbiome dysbiosis in neurodegenerative diseases
• Pathophysiology of REM sleep behavior disorder
• Major depressive disorder and neurodegeneration

• Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha-synucleinopathy Neurodegeneration, in a Prospective Family Cohort
• Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behavior Disorder: tracing a subtype of depression with underlying neurodegeneration

PhD student

Tel: (852) 3919-7792

Email: sygong@link.cuhk.edu.hk

ORCID: 0009-0001-3182-0568

Bachelor and Master’s degree (Soochow University)

• Gut microbiome dysbiosis in neurodegenerative diseases
• Pathophysiology of REM sleep behavior disorder
• Microbiota-targeted interventions, especially next-generation probiotics development
• Gastrointestinal disorder and neurodegeneration

1. Characterization of nocturnal movement-related brain activity in REM sleep behavior disorder
2. Colonic dysfunction and gut microbiome dysbiosis at prodromal alpha-synucleinopathy – towards a better understanding of aetiology and pathogenesis

Ms. CHAN obtained her bachelor’s degree from Hong Kong Baptist University. She is an MPhil student, supervised by Dr. LI Man Ho, Tim, in the Department of Psychiatry at the Chinese University of Hong Kong. Her MPhil program currently focuses on natural language processing for mental health.

PhD student in the Chinese University of Hong Kong

Background:
Bachelor’s degree in Clinical Medicine received from Shanghai Jiao Tong University
Master’s degree in Surgery received from Shanghai Jiao Tong University

Research Interests:
Child/adolescent mental health and development
Women’s mental health

Technican

Technican

Technician

Technician