Publications

2026

  1. Huang R, Xian L, Cheng CCW, Chen J, Chan KY, Lam C, Chan JWY, Chau SWH, Chan NY, Huang B, Wing YK, Li TMH. Exploring generalizability and explainability of LLMs in classifying clinically rated suicidal ideation using heterogeneous data. npj Digit Med. 2026. doi: 10.1038/s41746-026-03198-w.
  2. Man MSY, Au ALM, Cheng CCW, Siew MKY, Liu Y, Chan KY, Chen J, Chan JWY, Wing YK, Li TMH. Identification of suicidal ideation in major depressive disorder: A machine learning approach with multimodal digital features. PLOS Digit Health. 2026;5(8). doi: 10.1371/journal.pdig.0001615.
  3. Fan L, Li X, Wang X, Ni J, He Z, Yang Y, Yu H, Liang Z, Tang S, Gong S, Li N, Lin X, Ma X, Liu Y, Zhang J, Wang J, Chan JWY, Chan NY, Li TMH, Huang B, Wing YK. Multimodal AI for predicting comorbid REM sleep behavior disorder in major depressive disorder. npj Digit Med. 2026. doi: 10.1038/s41746-026-03001-w.
  4. Yip A, Li Tsang WPC, Yip J, Yip CKC, Li MHT, Tsui Z, Yip KMR, Lee KWG, Hung SYM. Molding the Pain into Porcelain: The Silent Resilience of Arthritic Hands in Hong Kong’s Ceramic Studios. Healthcare (Basel). 2026;14(8):1069. doi: 10.3390/healthcare14081069.
  5. Chong YY, Chan JKF, Yau PT, Li TMH, Fung KP, Chien WT. Videoconferencing acceptance and commitment therapy for parents of children with special health care needs: A randomised controlled trial. Int J Nurs Stud. 2026;179:105525. doi: 10.1016/j.ijnurstu.2026.105525.
  6. Lam C, Xian L, Huang R, Chen J, Chan KY, Chan JWY, Chau SWH, Chan NY, Li SX, Wing YK, Li TMH. Deep learning for detecting depression in individuals with and without alexithymia. Commun Med (Lond). 2026;6(1):123. doi: 10.1038/s43856-026-01393-0.
  7. So RWL, Chan KY, Cheng CCW, Chan NY, Li SX, Chan JWY, Chau SWH, Wing YK, Li TMH. Predicting adherence to fully-automated, chatbot-delivered digital cognitive behavioral therapy for insomnia (dCBT-I) using machine learning: A pilot real-world study. PLOS Digit Health. 2026;5(1). doi: 10.1371/journal.pdig.0001170.

2025

  1. Cheung T, Lam JYT, Fong KH, Cheng CP, Xiang YT, Li TMH. Efficacy of electrical vestibular stimulation (VeNS) on adults with insomnia: A double-blind, randomized, sham-controlled trial. Dialogues Clin Neurosci. 2025;27(1):236-248. doi: 10.1080/19585969.2025.2526547.
  2. Lam C, Chen J, Chan KY, Chan JWY, Chan NY, Li SX, Huang B, Wing YK, Li TMH. Identifying multimodal digital features of insomnia using an app in Hong Kong: An ecological momentary assessment study. Sleep Med. 2025;136:106825. doi: 10.1016/j.sleep.2025.106825.
  3. Mei X, Zheng N, Li B, Liu Y, Yang L, Luo T, Chan NY, Chan JWY, Liu Y, Tan X, Benedict C, Wing YK, Zhang J, Feng H. Wearable device-measured circadian rest-activity rhythm with mortality risk in patients with cancer. BMJ Health Care Inform. 2025;32(1). doi: 10.1136/bmjhci-2025-101553.
  4. Chan JWY, Chau SWH, Ng LY, Chan NY, Li TMH, Li SX, Ho AWY, Ho CS, Wing YK. Is it possible to change the chronotype? A prospective study in hospitalized patients with non-seasonal depression. Sleep Med. 2025;132:106546. doi: 10.1016/j.sleep.2025.106546.
  5. Sit HF, Cheung FTW, Li X, Chan NY, Chan JWY, Wing YK, Li SX. Unravelling symptom interplay of depression, anxiety, insomnia and suicidality in adolescents: A network analysis. Int J Clin Health Psychol. 2025;25(3):100619. doi: 10.1016/j.ijchp.2025.100619.
  6. Chan NY, Chen SJ, Ngan CL, Li SX, Zhang J, Lam SP, Chan JWY, Yu MWM, Chan KCC, Li AM, Wing YK. Advancing adolescent bedtime by motivational interviewing and text message: a randomized controlled trial. J Child Psychol Psychiatry. 2025;66(7):1005-1017. doi: 10.1111/jcpp.14115.
  7. Wang Y, Xie S, Chen S, Li C, Chan YL, Chan NY, Wing YK, Chan FKL, Su Q, Ng SC. The Role of Gut Microbiota in Insomnia: A Systematic Review of Case-Control Studies. Life (Basel). 2025;15(7):1086. doi: 10.3390/life15071086.
  8. Wang R, Mu Z, Li X, Cheung FTW, Chan NY, Chan JWY, Wing YK, Li SX. The relationship between NEO-five personality traits and sleep-related characteristics: A systematic review and meta-analysis. Sleep Med Rev. 2025;81:102081. doi: 10.1016/j.smrv.2025.102081.
  9. Yang Y, Wang J, Zhou L, Liu Y, Tang S, Gong S, Li N, He Z, Ni J, Chan JWY, Chau SWH, Wing YK, Huang B. Sleep related injury and its correlates in isolated rapid eye movement sleep behavior disorder. Sleep Med. 2025;126:9-18. doi: 10.1016/j.sleep.2024.11.032.
  10. Chan JWY, Li CT, Chau SWH, Chan NY, Li TMH, Huang B, Tsoh J, Li SX, Chong KKL, Roecklein KA, Wing YK. Attenuated melanopsin-mediated post-illumination pupillary response is associated with reduced actigraphic amplitude and mesor in older adults. Sleep. 2025;48(2). doi: 10.1093/sleep/zsae239.
  11. Chen SJ, Que JY, Chan NY, Shi L, Li SX, Chan JWY, Huang W, Chen CX, Tsang CC, Ho YL, Morin CM, Zhang JH, Lu L, Wing YK. Effectiveness of app-based cognitive behavioral therapy for insomnia on preventing major depressive disorder in youth with insomnia and subclinical depression: A randomized clinical trial. PLoS Med. 2025;22(1). doi: 10.1371/journal.pmed.1004510.

2024

  1. Yu DJ, Wing YK, Li TMH, Chan NY. The Impact of Social Media Use on Sleep and Mental Health in Youth: a Scoping Review. Curr Psychiatry Rep. 2024;26(3):104-119. doi: 10.1007/s11920-024-01481-9.
  2. Chen J, Chan NY, Li CT, Chan JWY, Liu Y, Li SX, Chau SWH, Leung KS, Heng PA, Lee TMC, Li TMH, Wing YK. Multimodal digital assessment of depression with actigraphy and app in Hong Kong Chinese. Transl Psychiatry. 2024;14(1):150. doi: 10.1038/s41398-024-02873-4.
  3. Huang R, Yi S, Chen J, Chan KY, Chan JWY, Chan NY, Li SX, Wing YK, Li TMH. Exploring the Role of First-Person Singular Pronouns in Detecting Suicidal Ideation: A Machine Learning Analysis of Clinical Transcripts. Behav Sci (Basel). 2024;14(3):225. doi: 10.3390/bs14030225.
  4. Cheung T, Yee BK, Chau B, Lam JYT, Fong KH, Lo H, Li TMH, Li AM, Sun L, Beisteiner R, Cheng CPW. Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial. Front Neurol. 2024;15:1364270. doi: 10.3389/fneur.2024.1364270.

2023

  1. Zhou L, Huang B, Wang J, Chau SW, Chan JW, Zhang J, et al. Early- and late-onset of isolated rapid eye movement sleep behavior disorder: A retrospective cohort study. Sleep Med. 2023;105:1-8.
  2. Lin Y, Huang B, Zhou L, Wang J, Shi T, Chau SWH, et al. The association of nocturnal enuresis with autonomic dysfunctions, mood disturbances and sleepwalking in isolated rapid eye movement sleep behavior disorder. Sleep. 2023;46(7).
  3. Jing W, Siu Ping L, Bei H, Yaping L, Jihui Z, Mandy WMY, et al. Familial α-synucleinopathy spectrum features in patients with psychiatric REM sleep behaviour disorder. Journal of Neurology, Neurosurgery & Psychiatry. 2023.
  4. Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, et al. Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives. Nat Commun. 2023;14(1):2501.
  5. Chau SWH, Liu Y, Zhang J, Leung E, Chen S, Ho CL, et al. Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study. Parkinsonism Relat Disord. 2023;107:105271.

2022

  1. Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, et al. Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study. Neurology. 2022;99(6).
  2. Zhou L, Chau SWH, Liu Y, Wang J, Zhang J, Chan NY, et al. Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder. NPJ Parkinsons Dis. 2022;8(1):91.
  3. Wang J, Chau SWH, Lam SP, Liu Y, Zhang J, Chan NY, et al. Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study. J Neurol Neurosurg Psychiatry. 2022;93(9):1010-7.
  4. Liu Y, Zhang J, Chau SWH, Man Yu MW, Chan NY, Chan JWY, et al. Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective Longitudinal Case-Control Study. Neurology. 2022;99(6).
  5. Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, et al. Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder. J Sleep Res. 2022.
  6. Tang S, Wang Y, Liu Y, Chau SW, Chan JW, Chu WC, et al. Large-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity. EBioMedicine. 2022;77:103915.
  7. Li TMH, Chan NY, Li CT, Chen J, Chan JW, Liu Y, Li SX, Li AM, Zhang J, Wing YK. The associations of electronic media use with sleep and circadian problems, social, emotional and behavioral difficulties in adolescents. Front Psychiatry 2022; 13:892583.
  8. Chan NY, Lam SP, Zhang J, Chan JWY, Yu MWM, Suh S, Yang CM, Okajima I, Li AM, Wing YK, Li SX. Efficacy of Email-delivered vs. Face-to-face Group Cognitive Behavioral Therapy for Insomnia in Youths: A Randomized Controlled Trial. J Adolesc Health. 2022 ;S1054-139X(21)00574-7. doi:10.1016/j.jadohealth.2021.11.005
  9. Chan NY, Au CT, Li SX, Wing YK. Sleep complaints among school children. Sleep Med Clin. 2022; 17(1):53-65.
  10. Merikanto I, Kortesoja L, Benedict C, Chung F, Cedernaes J, Espie CA, Morin CM, Dauvilliers Y, Partinen M, De Gennaro L, Wing YK, Chan NY, Inoue Y, Matsui K, Holzinger B, Plazzi G, Mota-Rolim SA, Leger D, Penzel T, Bjorvatn B. Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic – Multinational study on 19,267 adults. Sleep. 2022; 45(2).
  11. Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX. Neural Response to Rewards in Youths with Insomnia. Sleep. 2022;45(2).

2021

  1. Wang J, Chau SWH, Lam SP, Liu Y, Zhang J, Chan NY, Cheung MMS, Yu MWM, Tsang JCT, Chan JWY, Huang B, Li SX, Mok V, Wing YK. Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study. J Neurol Neurosurg Psychiatry. 2021. doi: 10.1136/jnnp-2021-327460
  2. Sun W, Kwok NTT, Chan NY, Chan JWY, Zhang J, Chan KC, Li SX. Associations of circadian factors with insomnia symptoms and emotional and behavioral problems among school-age children. J Clin Sleep Med. 2021;17(10):2107-2114.
  3. Partinen M, Holzinger B, Morin CM, Espie C, Chung F, Penzel T, Benedict C, Bolstad CJ, Cedernaes J, Chan RNY, Dauvilliers Y, De Gennaro L, Han F, Inoue Y, Matsui K, Leger D, Cunha AS, Merikanto I, Mota-Rolim S, Nadorff M, Plazzi G, Schneider J, Sieminski M, Wing YK, Bjorvatn B. Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire. BMJ Open. 2021;11(12). doi: 10.1136/bmjopen-2021-050672
  4. Morin CM, Bjorvatn B, Chung F, Holzinger B, Partinen M, Penzel T, Ivers H, Wing YK, Chan NY, Merikanto I, Mota-Rolim S, Macedo T, De Gennaro L, Leger D, Dauvilliers Y, Plazzi G, Nadorff MR, Bolstad CJ, Sieminski M, Benedict C, Cedernaes J, Inoue Y, Han F, Espie CA. Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study. Sleep Med. 2021;87:38-45.
  5. Lei B, Zhang J, Chen S, Chen J, Yang L, Ai S, Chan NY, Wang J, Dai XJ, Feng H, Liu Y, Li SX, Jia F, Wing YK. Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort. Sleep. 2021;44(8).
  6. Frankl E, Scarpelli S, Nadorff MR, Bjorvatn B, Bolstad CJ, Chan NY, Chung F, Dauvilliers Y, Espie CA, Inoue Y, Leger D, Macedo T, Matsui K, Merikanto I, Morin CM, Mota-Rolim S, Partinen M, Penzel T, Plazzi G, Sieminski M, Wing YK, De Gennaro L, Holzinger B. How our Dreams Changed During the COVID-19 Pandemic: Effects and Correlates of Dream Recall Frequency – a Multinational Study on 19,355 Adults. Nat Sci Sleep. 2021;13:1573-91.
  7. Chung F, Waseem R, Pham C, Penzel T, Han F, Bjorvatn B, Morin CM, Holzinger B, Espie CA, Benedict C, Cedernaes J, Saaresranta T, Wing YK, Nadorff MR, Dauvilliers Y, De Gennaro L, Plazzi G, Merikanto I, Matsui K, Leger D, Sieminski M, Mota-Rolim S, Inoue Y, Partinen M, Int CSS. The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study. Sleep Breath. 2021;25(2):849-860.
  8. Chen SJ, Zhang JH, Li SX, Tsang CC, Chan KCC, Au CT, Li AM, Kong APS, Wing YK, Chan NY*. The trajectories and associations of eveningness and insomnia with daytime sleepiness, depression and suicidal ideation in adolescents: A 3-year longitudinal study. J Affect Disord. 2021;294:533-542. (*corresponding author)
  9. Chan NY, Li SX, Zhang J, Lam SP, Kwok APL, Yu MWM, Chan JWY, Li AM, Morin CM, Wing YK. A Prevention Program for Insomnia in At-risk Adolescents: A Randomized Controlled Study. Pediatrics. 2021;147(3) . doi: 10.1542/peds.2020-006833
  10. Chan NY, Chan JWY, Li SX, Wing YK. Non-pharmacological Approaches for Management of Insomnia. Neurotherapeutics. 2021;18(1):32-43.
  11. Chan JW, Chan NY, Li SX, Lam SP, Chau SWH, Liu Y, Zhang J, Wing YK. Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference. J Clin Sleep Med. 2021; 18(2):523-531.
  12. Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX. Altered brain activity related to inhibitory processing in youth with insomnia. J Sleep Res. 2021;30(6). doi: 10.1111/jsr.13398
  13. Brandão LEM, Martikainen T, Merikanto I, Holzinger B, Morin CM, Espie CA, Bolstad CJ, Leger D, Chung F, Plazzi G, Dauvilliers Y, Matsui K, De Gennaro L, Sieminski M, Nadorff MR, Chan NY, Wing YK, Mota-Rolim SA, Inoue Y, Partinen M, Benedict C, Bjorvatn B, Cedernaes J. Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia – A Multi-National Survey Study. Nat Sci Sleep. 2021;13:1711-1722.

2020

  1. Feng Hongliang, Chen Lauren, Liu YP, Chen Xinru, Wang Jing, Yu MWM, Huang Bei, Li SX, Chau SWH, Chan JWY, Mok VCT, Wing YK*, Zhang JH. Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior disorder. Ann Neurol. 2020;88:817-829.
  2. Wang J, Liu YP, Chau, SWH, Zhang JH, Chan NY, Chan JWY, Li SX, Huang B, Feng HL, Mok VCT, Wing YK*. Residual injurious symptoms and neurodegenerative outcomes in idiopathic REM Sleep Behavior Disorder: a naturalistic longitudinal follow-up study. Mov Disord. 2020;35(11):2077-2085.
  3. Chan NY, Zhang JH, Tseng CC, Li AM, Chan JWY, Wing YK*, Li SX. The association of insomnia symptoms and chronotype with daytime sleepiness, mood symptoms and suicide risk in Adolescents. Sleep Med. 2020;74:124-131.
  4. Zhang Y, Ren R, Sanford LD, Yang L, Zhou J, Tan L, Li T, Zhang J, Wing YK, Shi J, Lu L, Tang X. Sleep in Parkinson’s disease: A systematic review and meta-analysis of polysomnographic findings. Sleep Med Rev. 2020; 51:101281.
  5. Yip TCF, Wong GLH, Tse YK, Yuen BWY, Luk HWS, Lam MHB, Li MKK, Loo CK, Tsang OTY, Tsang SWC, Chan HLY, Wing YK*, Wong VWS. High incidence of hepatocellular carcinoma and cirrhotic complications in patients with psychiatric illness: A territory-wide cohort study. BMC Gastroenterol. 2020, 20(1); 128.
  6. Zhang Y, Ren R, Sanford LD, Yang L, Ni Y, Zhou J, Zhang J, Wing YK, Shi J, Lu L, Tang X. The effects of prazosin on sleep disturbances in post-traumatic stress disorder: a systematic review and meta-analysis. (2020) Sleep Medicine, 67:225-231. Cited:1.
  7. Chan KC, Au CT, Hui LL, Wing YK, Li AM. Childhood OSA is an independent determinant of blood pressure in adulthood – a longitudinal follow-up study. Thorax. 2020. 202;75:422-431.
  8. Lau EYY, Lau KNT, Chan CS, Tseng CH, Lam YC, Tse DMS, Cheng WY, Chung KF, Wing YK. Effects of REM sleep during a daytime nap on emotional perception in individuals with and without depression. J Affect Disord. 2020;260:687-694.

2019

  1. Zhang Y, Ren R, Sanford LD, Yang L, Zhou J, Zhang J, Wing YK, Shi J, Lu L, Tang X. Sleep in posttraumatic stress disorder: A systematic review and meta-analysis of polysomnographic findings. Sleep Med Rev. 2019; 48:
  2. Lim LL, Tse G, Choi KC, Zhang J, Luk AOY, Chow E, Ma RCW, Chan MHM, Wing YK, Kong APS, Chan JCN. Temporal changes in obesity and sleep habits in Hong Kong Chinese school children: a prospective study. Sci Rep. 2019; 9(1):
  3. Au CT, Zhang J, Cheung JYF, Chan KCC, Wing YK, Li AM. Familial aggregation and heritability of obstructive sleep apnea using children probands. J Clin Sleep Med. 2019;15(11):1561-1570.
  4. Lau EYY, Wong ML, Rusak B, Lam YC, Wing YK, Tseng CH, Lee TMC. The coupling of short sleep duration and high sleep need predicts riskier decision making. Psychol Health Med. 2019;34 (10):1196-1213.
  5. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X. Response to commentary by Heidari and Arabzadeh on “Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis”. Sleep Med Rev. 2019;46:162-163.
  6. Chan KC, Au CT, Hui LL, Ng SK, Wing YK, Li AM. How OSA Evolves From Childhood to Young Adulthood: Natural History From a 10-Year Follow-up Study. Chest. 2019;156(1):120-130.
  7. Zhang Y, Ren R, Lei F, Zhou J, Zhang J, Wing YK, Sanford LD, Tang X. Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis. Sleep Med Rev. 2019;l45:1-17.
  8. Ding C, Zhang J, Lau ESH, Luk AOY, So WY, Ma RCW, Choi KC, Chan JCN, Wing YK*, Kong APS. Gender differences in the associations between insomnia and glycemic control in patients with type 2 diabetes: A cross-sectional study. Sleep. 2019; 42(4).
  9. Liu Y, Zhang J, Lam SP, Zhou J, Yu MWM, Li SX, Chan JWY, Postuma RB, Mok VCT, Wing YK*. A case–control–family study of idiopathic rapid eye movement sleep behavior disorder. Ann Neurol. 2019; 85(4):582-592.
  10. Liu Y, Zhang J, Lam SP, Yu MWM, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan A, Mok V, Wing YK. Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study. Sleep Med. 2019;56:128-134.