Sleep and Mental Health

Human impulsivity is a complex construct, referring to actions that are rapid, premature, with unduly risk and often inappropriate to the situation. Impulse control disorders (ICDs), as the most severe end of impulsivity, have been reported in approximately 14-20% patients with Parkinson’s disease (PD), especially related to the use of dopaminergic medications. Interestingly, increasing evidence showed that impulsivity already changed in drug naïve PD patients, which suggested impulsivity may be independently related to PD itself instead of only linked to dopaminergic medications. However, it remains unclear whether impulsivity has been altered in prodromal stages of PD, namely isolated rapid eye movement sleep behavior disorder (iRBD). Thus, we aimed to investigate the level of impulsivity across early stages of synucleinopathy, including patients with early drug-naïve PD, iRBD, first-degree relatives of iRBD, and normal controls.

1. iRBD patients and their first-degree relatives (including parents, siblings and offspring) with age ≥ 50y.
2. Early drug-naïve Parkinson’s disease patients (onset of symptoms less than 5 years) with age ≥ 50y.
3. Normal controls with age ≥ 50y.

We hope to invite you to Shatin Hospital or other related research sites for this study If the visit is inconvenient to you, we may also arrange home visits alternatively.

Procedures last around 2 hours, overnight sleep assessment and functional brain MRI study require further arrangements. All assessments are free of charge and each participant will receive HK$200 cash coupon as travel allowance. Each participant will also receive HK$200 cash coupon as travel allowance if undergos functional brain MRI study.