Neural correlates of impulsivity in idiopathic REM sleep behavior disorder and Parkinson’s disease: a functional Magnetic Resonance Imaging case-control study
Impulsivity is a complex construct, which incorporates failure of response inhibition, rapid processing of information, novelty seeking, and inability to delay gratification. Robust evidence does suggest that impulsive control disorder (ICD) in Parkinson’s disorder (PD) can be quite frequent and is often associated with the use of dopaminergic medication. Idiopathic REM sleep behavior disorder (RBD) is a distinct parasomnia characterized by recurrent dream enacting behaviors and polysomnographic features of REM sleep without atonia. Increasing studies suggested that a large proportion of patients with iRBD eventually developed clinically diagnosed α-synucleinopathies such as PD. Recent study also suggests that the impulsivity features has already changed in iRBD. We therefore propose to examine the neural correlates of impulsivity in iRBD and patients with PD, which would expand the current understanding on the evolution of impulse control/impulsivity across prodromal stages of α-synucleinopathy.
- iRBD patients
- early PD patients(both medicated and unmedicated) converted from iRBD
- healthy control subjects
We hope to invite you to Shatin Hospital and Prince of Wales Hospital for this study.
Study content:
- Questionnaires
- Clinical interviews (sleep and mood assessments)
- Neurocognitive tests, Overnight sleep assessment
- Brain Magnetic Resonance Imaging scan combined electroencephalogram.
Procedures last around 1-hour, overnight sleep assessment requires further arrangements. All assessments are free of charge and each participant will receive HK$200 cash coupon as travel allowance.
