Dr. Hei Ming LAI
Assistant Professor (by courtesy)
Assistant Professor (by courtesy)
黎曦明醫生
MBBS(HKU)
Fax: (852) 2618-9190
Email: hmlai@cuhk.edu.hk
ORCID: 0000-0001-5150-7918
RESEARCH INTERESTS:
- Chemical and molecular biology tools for studying neuropsychiatric diseases
- Molecular and circuitry mechanisms of normal and pathological brain functioning
- Biomarkers for neuropsychiatric diseases
- Neuropsychopharmacology
AWARDS:
- 46th International EXhibitions of Inventions Geneva, Switzerland, Gold Medal Award
CURRENT PROJECTS:
- Advanced human and animal brain tissue research methods
- Biomarker discovery in psychiatric diseases
RESEARCH FACILITIES AND EQUIPMENT:
- Thorlabs CMLS-F 4-channel Confocal Microscope
- MesoSPIM Light Sheet Microscope (https://mesospim.org/setups/#)
- Neuropixels 1.0 probes
- Waters ACQUITY Arc Bio High-Performance Liquid Chromatography system
SELECTED PUBLICATIONS:
- Zhao J, He D, Lai HM, Xu Y, Luo Y, Li T, Liang J, Yang X, Guo L, Ke Y, Zhou H, Wu W, Guo H, Sun H.
Comprehensive histological imaging of native microbiota in human glioma.
J Biophotonics. 2021 Dec 22:e202100351.
doi: 10.1002/jbio.202100351. - Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H.
Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner.
Commun Biol. 2021 Jun 2;4(1):656. - Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL.
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
ACS Cent Sci. 2021 May 26;7(5):792-802. doi: 10.1021/acscentsci.0c01186. - Lee K, Lai HM, Soerensen MH, Hui ES, Ma VW, Cho WC, Ho YS, Chang RC.
Optimised tissue clearing minimises distortion and destruction during tissue delipidation.
Neuropathol Appl Neurobiol. 2021 Apr;47(3):441-453. doi: 10.1111/nan.12673. - Zhao J, Lai HM, Qi Y, He D, Sun H.
Current Status of Tissue Clearing and the Path Forward in Neuroscience.
ACS Chem Neurosci. 2021 Jan 6;12(1) - Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian X, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT, Ko H.
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.
Nat Commun. 2020 Sep 4;11(1):4413. - Ren YX, Wu J, Lai QTK, Lai HM, Siu DMD, Wu W, Wong KKY, Tsia KK.
Parallelized volumetric fluorescence microscopy with a reconfigurable coded incoherent light-sheet array.
Light Sci Appl. 2020 Jan 20;9:8. - Lai HM, Liu AKL, Ng HHM, Goldfinger MH, Chau TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM.
Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.
Nat Commun. 2018; 9:1066. - Lai HM, Ng WL, Gentleman SM, Wu W.
Chemicals Probes for Visualizing Intact Animal and Human Brain Tissue.
Cell Chem Biol 2017; 24:659-672. - Liu AKL, Lai HM, Chang RC, Gentleman SM.
Free-of-acrylamide SDS-based Tissue Clearing (FASTClear): A novel protocol of tissue clearing for three-dimensional visualisation of human brain tissues.
Neuropathol Appl Neurobiol. 2016; 43:346-351.
