STAFFS

• Director of Li Chiu Kong Family Sleep Assessment Unit

• Awarded by Chinese Sleep Research Society for distinguished contributions to the development of sleep medicine and sleep research in May 2016
• Awarded the distinguished national award for Sleep Medicine Scientific Technological Advance in China by the Chinese Medical Doctor Association in September 2010, Beijing, China

• Sleep medicine
• Biological and cultural psychiatry
• Neuropsychiatry
• Transcultural psychopharmacology
• Digital mental health

(In a capacity of PI/Co-PI)

• Title: Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing (From 2023 to 2025)
Funding source: Collaborative Research Fund (RGC GRF)
Position: PI

• Title: Digital mental health in depression – deep phenotyping and monitoring (From 2022 to 2024)
Funding source: Health and Medical Research Fund (HMRF)
Position: PI

• Title: Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study (From 2021 to 2025)
Funding source: General Research Fund (RGC GRF)
Position: PI

• Title: Multi-modal approaches to determine digital clinical phenotyping, novel proteomic biomarkers, and microbiota-host responses of REM sleep behavior disorder, a prodromal stage of α-synucleinopathy neurodegeneration, in a prospective family cohort (From 2022 to 2025)
Funding source: Collaborative Research Fund (RGC CRF)
Position: PI

• Title: Striatal dopamine transmission and prodromal markers of α-synucleinopathy neurodegeneration in recurrent dream enactment behaviors without REM sleep without atonia: a case-control study (From 2021 to 2024)
Funding source: General Research Fund (RGC GRF)
Position: PI

• Title: Gut microbiota in major depressive disorders with and without Rapid Eye Movement Behaviour Disorder: tracing a subtype of depression with underlying neurodegeneration (From 2021 to 2024)
Funding source: Health and Medical Research Fund (HMRF)
Position: PI

• Title: A 7-year prospective study of idiopathic REM sleep behavior disorder cohort in Chinese population: determining the optimal characteristics of prodromal markers to predict neurodegenerative diseases (From 2019 to 2023)
Funding source: Health and Medical Research Fund (HMRF)
Position: PI

• Title: Neuropsychiatric ‘long-COVID’ in adult patients (From 2022 to 2023)
Funding source: Collaborative Research Fund (RGC CRF)
Position: Co-PI

• Title: Psychological resilience and mental wellness: Effects of internal neurobiological affective and external social support system (From 2020 to 2023)
Funding: Collaborative Research Fund (CRF)
Position: Co-PI

(In a capacity of Co-I)

• Title: Effects of cognitive behavioral therapy and bright light therapy in youth with unipolar depression and evening chronotype: An assessor-blind, parallel-group, randomized controlled trial (From 2023 to 2025)
Funding source: General Research Fund (GRF)
Position: Co-I

• Title: An Artificial Intelligence chatbot for sleep education (From 2022 to 2024)
Funding source: Knowledge Transfer Project Fund
Position: Co-I

• Title: Randomized placebo – and active -controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease (From 2022 to 2025)
Funding source: Health and Medical Research Fund (HMRF)
Position: Co-I

• Title: Prevention of insomnia in at risk youth: A randomized controlled trial comparing cognitive behavioral prevention program for insomnia with active control condition (From 2022 to 2024)
Funding source: General Research Fund (GRF)
Position: Co-I

1. Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, Zhang J, Chan PKS, Yeoh YK, Chen Z, Zhou L, Wong SH, Mok VCT, To KF, Lai HM, Ng S, Trenkwalder C, Chan FKL, Wing YK.
   Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives.
   Nature Communications. 2023 May 2;14(1):2501.
2. Morin CM, Bei B, Bjorvatn B, Poyares D, Spiegelhalder K, Wing YK.
   Governing Council of the World Sleep Society. World sleep society international sleep medicine guidelines position statement endorsement of “behavioral and psychological treatments for chronic insomnia disorder in adults: An American Academy of sleep medicine clinical practice guidelines”.
   Sleep Medicine. 2023 Jul 4;109:164-169.
3. Wang J, Lam SP, Huang B, Liu Y, Zhang J, Yu MWM, Tsang JCC, Zhou L, Chau SWH, Chan NY, Chan JWY, Schenck CH, Li SX, Mok VCT, Ma KKY, Chan AYY, Wing YK.
   Familial α-synucleinopathy spectrum features in patients with psychiatric REM sleep behaviour disorder.
   Journal of Neurology, Neurosurgery, and Psychiatry. 2023 Jun 30: jnnp-2022-330922.
4. Chan NY, Wu WJ, Chan JWY, Chan KCC, Li AM, Chan SSM, Hau KT, Wing YK.
   Sleep and academic performance among students in Hong Kong: Curvilinear relationship suggesting an optimal amount of sleep.
   Sleep Medicine. 2023 Jun; 106:97-105.
5. Feng H, Yang L, Liang YY, Ai S, Liu Y, Liu Y, Jin X, Lei B, Wang J, Zheng N, Chen X, Chan JWY, Sum RKW, Chan NY, Tan X, Benedict C, Wing YK, Zhang J.
   Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study.
   Nature Communications. 2023 Feb 18;14(1):930.
6. Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Penzel T, Holzinger B, Partinen M, Wing YK.
   Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.
   Journal of Sleep Research. 2023 Feb;32(1):e13613.
7. Chen J, Li CT, Li TMH, Chan NY, Chan JWY, Liu Y, Lee TMC, Wing YK.
   A forgotten sign of depression – the omega sign and its implication.
   Asian Journal of Psychiatry. 2023 Feb;80:103345.
8. Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan CCY, Chan DCW, Wong TY, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H.
   Antibody stabilization for thermally accelerated deep immunostaining.
   Nature Methods. 2022 Sep;19(9):1137-1146.
9. Chen CX, Li TMH, Zhang J, Li SX, Yu MWM, Tsang CC, Chan KCC, Au CT, Li AM, Kong APS, Chan JWY, Wing YK, Chan NY.
   The impact of sleep-corrected social jetlag on mental health, behavioral problems, and daytime sleepiness in adolescents.
   Sleep Medicine. 2022 Dec;100:494-500.
10. Chan JW, Lam SP, Li SX, Chau SW, Chan SY, Chan NY, Zhang JH, Wing YK.
    Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial.
    Psychological Medicine. 2022 Jun;52(8):1448-1457.

• 1981-1998
  Foundation Chairman, Professor of Psychiatry
• 1987-1994
  Foundation Head of Shaw College
• 1992-1998
  Honorary Chief of Service of Department of Psychiatry in Prince of Wales Hospital
• 1996-1998
  Honorary Chief of Service of Department of Psychiatry in Shatin Hospital

• Officer of the Most Excellent Order of the British Empire (OBE) – Appointed by Her Majesty, The Queen of The United Kingdom
• Honorary Fellow (2008), Shaw College, CUHK
• International Distinguished Fellow (since 2012), American Psychiatric Association
• Honorary Fellow (2014), Hong Kong College of Psychiatrists
• Special Contribution Award, Chinese Sleep Research Society
• Emeritus Professorship in 2018

• Past President of International Psychogeriatric Association
• Past President of Pacific Rim College of Psychiatrists
• Past President of the Hong Kong College of Psychiatrists
• Past President of the Hong Kong Psychogeriatric Association
• Chairman of Psychogeriatric Working Group
• Honorary Member of the Hong Kong Alzheimer’s Disease and Brain Failure Association
• Member of Medical and Advisory Panel of the Alzheimer’s Disease International
• Adjunct Professor, Department of Psychiatry, University of Rochester, NY, USA
• Member of Review Sub-committee of Licentiate Committee of the Medical Council of Hong Kong
• Honorary Consultant, the Caritas, Social Work Division
• Co-ordinator of 10/66 Dementia Research Group China and South East Asia Network
• Past Member of Elderly Commission
• Member of Long Term Prison Commission

• Medal of Honor by HKSAR in 1999
• International Psychogeriatric Association Distinguished Service Award in 2011

• Geriatric psychiatry
• Dementia
• Suicide

1. Chiu HFK, Zhong BL, Leung T, Li SW, Chow P, Tsoh J, Yan C, Xiang YT, Wong M.
   Development and validation of a new cognitive screening test: The Hong Kong Brief Cognitive Test (HKBC).
   Int J Geriatr Psychiatry. 2018 Apr 11.
2. Lam Nogueira BOC, Li L, Meng LR, Ungvari GS, Ng CH, Chiu HFK, Kuok KCF, Tran L, Xiang YT.
   Clinical characteristics and quality of life of older adults with cognitive impairment in Macao.
   Psychogeriatrics. 2018 Feb 6
3. Lam Nogueira BOC, Li L, Meng LR, Ungvari GS, Ng CH, Chiu HFK, Kuok KCF, Tran L, Xiang YT.
   Clinical characteristics and quality of life of older adults with cognitive impairment in Macao.
   Psychogeriatrics. 2018 Feb 6.
4. Zhong XM, Wang F, Zhang Q, Ungvari GS, Ng CH, Chiu HFK, Si TM, Sim K, Avasthi A, Grover S, Chong MY, Chee KY, Kanba S, Lee MS, Yang SY, Udomratn P, Kallivayalil RA, Tanra AJ, Maramis MM, Shen WW, Sartorius N, Mahendran R, Tan CH, Shinfuku N, Xiang YT.
   Concurrent benzodiazepine use in older adults treated with Antidepressants in Asia.
   Int Psychogeriatr. 2017 Dec 7:1-7.
5. Bhugra D, Tasman A, Pathare S, Priebe S, Smith S, Torous J, Arbuckle MR, Langford A, Alarcón RD, Chiu HFK, First MB, Kay J, Sunkel C, Thapar A, Udomratn P, Baingana FK, Kestel D, Ng RMK, Patel A, Picker L, McKenzie KJ, Moussaoui D, Muijen M, Bartlett P, Davison S, Exworthy T, Loza N, Rose D, Torales J, Brown M,  Christensen H, Firth J, Keshavan M, Li A, Onnela JP, Wykes T, Elkholy H, Kalra G, Lovett KF, Travis MJ, Ventriglio A. 
   The WPA-Lancet Psychiatry Commission on the Future of Psychiatry.
   Lancet Psychiatry. 2017 Oct;4(10):775-818.
6. Zhong BL, Chan SSM, Liu TB, Jin D, Hu CY, Chiu HFK.
   Mental health of the old-and new-generation migrant workers in China: who are at greater risk for psychological distress?
   Oncotarget. 2017 Mar 7;8(35):59791-59799.
7. Li L, Wang YY, Wang SB, Li L, Lu L, Ng CH, Ungvari GS, Chiu HFK, Hou CL, Jia FJ, Xiang YT.
   Sleep Duration and Sleep Patterns in Chinese University Students: A Comprehensive Meta-Analysis.
   J Clin Sleep Med. 2017 Oct 15;13(10):1153-1162.
8. Li XH, An FR, Ungvari GS, Ng CH, Chiu HFK, Wu PP, Jin X, Xiang YT.
   Prevalence of smoking in patients with bipolar disorder, major depressive disorder and schizophrenia and their relationships with quality of life.
   Sci Rep. 2017 Aug 16;7(1):8430.
9. Li XH, An FR, Ungvari GS, Ng CH, Chiu HFK, Wu PP, Jin X, Xiang YT. Prevalence of smoking in patients with bipolar disorder, major depressive disorder and schizophrenia and their relationships with quality of life.
   Sci Rep. 2017 Aug 16;7(1):8430.
10. Wang S, Wu Y, Ungvari GS, Ng CH, Forester BP, Gatchel JR, Chiu HFK, Kou C, Fu Y, Qi Y, Yu Y, Li B, Xiang YT.
    Sleep duration and its association withdemographics, lifestyle factors, poor mental health and chronic diseases in older Chinese adults.
    Psychiatry Res. 2017 Nov;257:212-218.

• Fellow, The Hong Kong Academy of Medicine, 1994.
  香港醫學專科學院院士 (1994)
• Freeman Foundation Fellowship, Department of Social Medicine, Harvard Medical, School, Boston, USA, 1996-7.
  美國哈佛大學醫學院 社會醫學系Freeman Foundation 訪問學人 (1996 – 1997)
• Fellow, Royal College of Psychiatrists (FRCPsych, UK), 1999.
  英國皇家精神科醫學院榮授院士 (1999)
• Lecturer, Department of Global Health and Social Medicine, Harvard Medical School, USA, 1997-2003.
  美國哈佛大學醫學院 全球健康與社會醫學系講師 (1997 – 2003)
• Advisor to the Eating Disorders Work Group of the DSM-IV (1994), American Psychiatric Association, USA.
  美國精神醫學會 精神疾病的診斷與統計手冊 進食失調症工作組顧問 (1994)
• Advisor to Section on Eating Disorders, DSM-Text Revision (2000) Work Group, American Psychiatric Association, USA
  美國精神醫學會 精神疾病的診斷與統計手冊(修定版)進食失調症工作組顧問 (2000)
• Chairman, Section on classification and diagnostic assessment, World Psychiatric Association (WPA), 1999-2003.
  世界精神病學協會 疾病分類及診斷評估組主席 (1999 – 2003)
• Director, Hong Kong Eating Disorders Center, The Chinese University of Hong Kong, 1999-2019.
  香港中文大學 香港進食失調中心 中心主管 (1999 – 2019)
• Director, Hong Kong Mood Disorders Center, The Chinese University of Hong Kong, 2001-2019.
  香港中文大學 香港健康情緒中心 中心主管 (2001 – 2019)
• Member of the “Somatic Symptom and Related Disorders” workgroup of the DSM-5, American Psychiatric Association, USA, 2006-2013.
  美國精神醫學會 精神疾病的診斷與統計手冊 身體症狀及相關障礙工作組成員 (2006 – 2013)
• Asia-Pacific regional coordinator, World Mental Health Initiative; previously Chief Scientific Advisor, World Mental Health Survey in China (Beijing, Shanghai), organized by Harvard School of Public Health and World Health Organization, since 2000.
  美國哈佛大學公共衛生學院及世界衛生組織主辦 世界精神衛生調查行動 亞太區協調員; 美國哈佛大學公共衛生學院及世界衛生組織主辦 世界精神衛生調查行動 世界心理健康調查(北京及上海)前首席科學顧問 (自2000年起)
• Board member of the Hong Kong Eating Disorders Association.
  香港進食失調康復會董事局成員
  Founding advisor of the Hong Kong FamilyLink Mental Health Advocacy Association.
  香港家連家精神健康倡導協會創始顧問
• Clarivate Analytics “Highly Cited Researchers 2018, 2019, and 2020”
  Clarivate Analytics 「2018, 2019 及 2020 年最廣獲徵引研究人員」

• Assistant Dean (Student support), Faculty of Medicine, CUHK (2016- )  
• Chairman, Graduate School Disciplinary Committee, CUHK (2020- )  
• Chairman, Special Interest Group in Clinical Neuroscience, The Hong Kong College of Psychiatrists 
• Committee Member, Committee on Complaints against Private Health Care Facilities, Department of Health (2021-2023 )  
• Chairman and convener of the DEC Sub-Committee for MMR, Executive Committee member, The Mental Health Association of Hong Kong (2017- )
• Vice-chairman of Executive Committee, The Mental Health Association of Hong Kong (2024-  )
• Executive Committee member, HATCH (Hub of Advanced Technology for Child Health), The DH Chen Foundation (2022- )

• Pacific Rim College of Psychiatrists’ Research Award: Best original research on Mood Disorder 2006 “Elderly Suicide and 2003 SARS Epidemic”
• Faculty Education Award 2021

• Specialists in Psychiatry with the Hong Kong College of Psychiatrists (Fellowship in 2005) and The Royal College of Psychiatrists (UK) (Membership in 2001/ Fellowship in 2015)
• National Institute of Health’s ICOHRTA Fellowship ( Suicide prevention and research) with University of Rochester, USA (2002-03)
• Visiting Fellowship at Martinos Centre for Biomedical Imaging(2012)/Berenson-Allen Center for Non Invasive Brain Stimulation, Harvard Medical School (2013)
• Certified Completion of Training in Psychoanalytic Psychotherapy with The China American Psychoanalytic Alliance (CAPA) (2013-2014)

• Functional brain mapping of mood disorders and neurodevelopmental disorders 
• Network-informed transcranial magnetic stimulation for psychiatric disorders 
• Neuromodulation for cognitive remediation in childhood neurodevelopmental disorders 
• Treatment resistant depression 
• Digital mental health platform 
• Resilience and developmental mental health 
• Suicide prevention 

1. Phase I of the Commissioned Study on Mental Health Survey: Hong Kong Child and Adolescent Psychiatric Epidemiologic Survey: Age 6 to 17
   (Co-I/Executive Director, External Grant: FHB-MHS-P1(Part 1)-CUHK)
2. Relationship between social motivation tendency, schizophrenia symptoms, and social functioning
   (Co-I, External Grant: Research Grant Council/ GRF 14605020)
3. Establishing the electro-physiological basis of inner speech deficits in Schizophrenia
   (Co-I, External Grant: Research Grant Council/ GRF 14601122)
4. Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning
   (PI, External Grant: Research Grant Council/ GRF 14120322)
5. A mobile-phone-based intervention for caregivers of adolescents – empowerment through mindfulness-based and empathy-guided continuous learning and support programme
   (Co-I, External Grant: Mental Health Initiatives Fund- Phase I/ MH-0068)
6. Double-blind randomized controlled trial with t-DCS on pre-pubertal Autism Spectrum Disorder comorbid with ADHD
   (Project supervisor under HATCH research team) 
7. Microbiome signature in ASD- case-controlled study in pre-pubertal children
   (Project supervisor under HATCH research team) 

1. Chan SSM, Chiu HFK, Lam LCW, Leung VPY.
   Elderly Suicide and the 2003 SARS epidemic in Hong Kong SAR.
   International Journal of Geriatric Psychiatry 2006; 21:113-18.
2. Chan SSM, Lyness JM, Yeates C.
   Do Cerebrovascular Risk Factors Confer Risk for Suicide in Later Life? A Case-control Study.
   American Journal of Geriatric Psychiatry 2007; 15: 541-44
3. Liu J, Ma H, He YL, Xie B, Xu YF, Tang HY, Li M, Hao W, Wang XD, Zhang MY, Ng CH, Goding M, Fraser J, Herrman H, Chiu HFK, Chan SSM, Chiu E, Yu X.
   Mental health system in China: history, recent service reform and future challenges.
   World Psychiatry 2011; 10 (3): 210-16.
4. Chan SSM, Leung PY, Tsoh J, Li SW, Yu CS, Yu KK, Poon TK, Pan PC, Chan WC, Conwell Y, Lam LCW, Chiu HFK.
   Outcomes of a two-tiered multi-faceted elderly suicide prevention program in a Hong Kong Chinese Community.
   American Journal of Geriatric Psychiatry 2011;19: 185-96.
5. So SHW, Chan GHK, Wong CKW, Ching EWK, Lee, SSW, Wong BCW, Chen Z, Sun X, Chung, LKH, Hung AY, Wong JOY, Chan SSM.
   A randomized controlled trial of metacognitive training for psychosis, depression and belief flexibility.
   Journal of Affective Disorders 2020; 279(15): 388-39.
6. Hopman HJ, Choy HY, Ho WS, Lu H, Wong WH, Chan SSM.
   The effects of repetitive transcranial magnetic stimulation antidepressant response on cold cognition: a single-arm prospective longitudinal study.
   Neuropsychiatric Disease and Treatment 2021; 17: 1-12.
7. Hopman HJ (co-first author), Chan SSM (co-first author), Chu CWW, Lu H, Tse CY, Chau SWH, Lam LCW, Mak ADP, Neggers SFW.
   Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment refractory depression using neuroimaging biomarkers and machine learning.
   Journal of Affective Disorders 2021; 290: 261-271.
8. Wong OWH, Lam AMW, Lai KYC, Ma SL, Hung SF, Chan S, Wong S, Leung PWL.
   An elevated anxiety level amongprepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case–control study.
   Autism Research 2021; 14(10): 2131-2142.
9. Chan VKY, Cheung ECL, Chan SSM, Knapp M, Hayes JF, Fan M, Lai FTT, Luo H, Lum T, Wong RSM, Lau LKW, Wan EYF, Wong GHY, Chan EWY, Ip P, Wong ICK, Li X.
   Mortality-causing mechanisms and healthcare resource utilisation of treatment-resistant depression: A six-year population-based cohort study.
   The Lancet Regional Health – Western Pacific 2022;22: 100426
10. Wong OWH, Angela LMW, Or BPN, Lai K, Ma SL, Hung SF, Chan S, Kwong TNH, Wong S, Leung PWL.
    Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case-control study on prepubertal Chinese boys.
    Scientific Reports 2022: 12:10659

• Past President, The Hong Kong College of Psychiatrists
• Past Chief Editor, East Asia Archives of Psychiatrists
• Council Member, The Hong Kong College of Psychiatrists
• Founding President, The Chinese Dementia Research Association
• Associate Editor, Editorial Board of International Psychogeriatrics

• Early detection and intervention for Mild Cognitive Impairment and dementia
• Biomarker evaluation for Mild Cognitive Impairment and dementia
• Determinants of Health Aging
• Epidemiology of mental disorders in Hong Kong

1. Wong PCM, Ou J, Pang CWY, Zhang L, Tse CS, Lam LCW.
   Antoniou M.Language Training Leads to Global Cognitive Improvement in Older Adults: A Preliminary Study.
   J Speech Lang Hear Res. 2019 Jul 15;62(7):2411-2424.
2. Ma SL, Tang NLS, Wat KHY, Tang JHY, Lau KH, Law CB, Chiu J, Tam CCW, Poon TK, Lin KL, Kng CPL, Kong HL, Chan TY, Chan WC, Lam LCW.
   Effect of CYP2D6 and CYP3A4 Genotypes on the Efficacy of Cholinesterase Inhibitors in Southern Chinese Patients With Alzheimer’s Disease.
   Am J Alzheimers Dis Other Demen. 2019 Aug;34(5):302-307.
3. Mak AD, Chung VCH, Yuen SY, Tse YK, Wong SYS, Ju Y, Hung SS, Leung KC, You JHS, Lui R, Wong SH, Leung ONW, Lam LCW, Lee S, Wu JCY.
   Noneffectiveness of electroacupuncture for comorbid generalized anxiety disorder and irritable bowel syndrome.
   J Gastroenterol Hepatol. 2019 Mar 19.
4. Lu H, Chan SSM, Lam LCW.
   Localized Analysis of Normalized Distance from Scalp to Cortex and Personalized Evaluation (LANDSCAPE): Focusing on Age- and Dementia-Specific Changes.
   J Alzheimers Dis. 2019;67(4):1331-1341.
5. Ho RTH, Fong TCT, Chan WC, Kwan JSK, Chiu PKC, Yau JCY, Lam LCW.
   Psychophysiological effects of Dance Movement Therapy and physical exercise on older adults with mild dementia: A randomized controlled trial.
   J Gerontol B Psychol Sci Soc Sci. 2018 Nov 28.
6. Ho RTH, Fong TCT, Hon T, Chan WC, Kwan JSK, Chiu PKC, Lam LCW.
   Psychometric validation of Fuld Object Memory Evaluation in older adults with cognitive impairments.
   Aging Ment Health. 2019 Jun;23(6):711-717.
7. Fung AW, Lam LCW.
   Validation of a computerized Hong Kong – vigilance and memory test (HK-VMT) to detect early cognitive impairment in healthy older adults.
   Aging Ment Health. 2018 Oct 1:1-7.
8. Mak ADP, Chan AKW, Chan PKL, Tang CP, Lai K, Wong S, Leung P, Hung SF, Lam LCW, Lee S.
   Diagnostic Outcomes of Childhood ADHD in Chinese Adults.
   J Atten Disord. 2018 Sep 27:1087054718802015.
9. Cheng ST, Lam LCW.
   Improving diagnostic communication in dementia.
   Int Psychogeriatr. 2018 Aug;30(8):1149-1152.
10. Lu H, Ni X, Fung AWT, Lam LCW.
    Mapping the Proxies of Memory and Learning Function in Senior Adults with High-performing, Normal Aging and Neurocognitive Disorders.
    J Alzheimers Dis. 2018;64(3):815-826.

• Honoary Consultant, New Territories East Cluster, Hospital Authority

• Neuropsychiatry in Stroke
• Substance abuse

1. Substance Abuse Clinic Registry.
2. Self Harm in Substance Use Disorders.
3. Adverse Mental Health Effects of a New Psychotropic Substance (Synthetic Cathinones) Use: a Literature Review.
4. Adverse Mental Health Effects of Cannabis Use: A Literature Review and a Prevalence Study in Local Cannabis Abusers.
5. Neuropsychiatric Registry at Acute Stroke Unit at Prince of Wales Hospital.
6. Risk of Self Harm after Transient Ischemic Attack and Subarachnoid Haemorrhage in Kong Kong: a retrospective study.

1. Liang Y, Chen YK, Liu YL, Mok VCT, Ungvari GS, Chu WCW, Tang WK, Kim JS, Kim JM.
   Exploring causal pathways linking cerebral small vessel diseases burden to poststroke depressive symptoms with structural equation model analysis.
   J Affect Disord. 2019 Jun 15;253:218-223.
2. Wong SY, Tang WK, Mak WW, Cheung FM, Mercer S, Griffiths SM, Woo J, Lee DT, Kung K, Lam AT.
   Stepped care programme in primary care to prevent anxiety and depression: a randomised clinical trial.
   Hong Kong Med J. 2019 Feb;25 Suppl 3(1):9-10.
3. Cumming TB, Yeo AB, Marquez J, Churilov L, Annoni JM, Badaru U, Ghotbi N, Harbison J, Kwakkel G, Lerdal A, Mills R, Naess H, Nyland H, Schmid A, Tang WK, Tseng B, van de Port I, Mead G, English C.
   Investigating post-stroke fatigue: An individual participant data meta-analysis.
   J Psychosom Res. 2018 Oct;113:107-112.
4. Tang WK, Wong LK, Mok VC, Chu WC, Wang DF.
   Apathy after stroke: potential risk factors and magnetic resonance imaging markers.
   Hong Kong Med J. 2018 Jun;24 Suppl 3(3):18-20.
5. Liang Y, Chen YK, Mok VC, Wang DF, Ungvari GS, Chu WC, Kang HJ, Tang WK.
   Cerebral Small Vessel Disease Burden Is Associated With Poststroke Depressive Symptoms: A 15-Month Prospective Study.
   Front Aging Neurosci. 2018 Feb 28;10:46.
6. Wong SYS, Sun YY, Chan ATY, Leung MKW, Chao DVK, Li CCK, Chan KKH, Tang WK, Mazzucchelli T, Au AML, Yip BHK.
   Treating Subthreshold Depression in Primary Care: A Randomized Controlled Trial of Behavioral Activation With Mindfulness.
   Ann Fam Med. 2018 Mar;16(2):111-119.
7. Zhang C, Tang WK, Liang HJ, Ungvari GS, Lin SK.
   Other drug use does not impact cognitive impairments in chronic ketamine users.
   Drug Alcohol Depend. 2018 May 1;186:1-8.
8. Liang Y, Chan YL, Deng M, Chen YK, Mok V, Wang F, Ungvari GS, Chu CW, Tang WK.
   Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study.
   J Affect Disord. 2018 Mar 1;228:166-172.
9. Liang Y, Chen YK, Deng M, Mok VCT, Wang DF, Ungvari GS, Chu CW, Kamiya A, Tang WK.
   Association of Cerebral Small Vessel Disease Burden and Health-Related Quality of Life after Acute Ischemic Stroke.
   Front Aging Neurosci. 2017 Nov 13;9:372.
10. Liang Y, Deng M, Chen YK, Mok V, Wang DF, Ungvari GS, Chu CW, Berge E, Tang WK.
    Enlarged perivascular spaces are associated with health-related quality of life in patients with acute ischemic stroke.
    CNS Neurosci Ther. 2017 Dec;23(12):973-979.

• Honorary Secretary, The Hong Kong Society of Sleep Medicine 

• Circadian rhythm and neuropsychiatric disorders
• Clinical application of chronotherapeutic treatments
• Circadian biomarkers
• Sleep disorders and psychiatric illness

• Distinguished Young Fellow, the Hong Kong Academy of Medicine, 2022

1.  Randomized placebo- and active-controlled trial for assessing the efficacy of bright light therapy for sleep and mood symptoms in patients with Parkinson’s disease. Funded by Health and Medical Research Fund –Food and Health Bureau. Capacity: PI. Study duration: 1/8/2022-31/7/2025
2. A randomized placebo-controlled trial for adjunctive bright light therapy in patients with bipolar depression and eveningness. Funded by General Research Fund, Research Grants Council. Capacity: PI. Study duration: 1/1/2022 – 31/12/2023
3. Melanopsin-mediated pupillary response in patients with rapid eye movement sleep behaviour disorder. Funded by Direct Grant, CUHK. Capacity: PI. Study duration: 10/6/2022 – 9/12/2023
4. Efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) with artificial intelligence chatbot for youth with insomnia: An assessor-blind, randomized controlled trial. Funded by General Research Fund, Research Grants Council. Capacity: Co-I. Study duration: 01/01/2024 – 30/06/2026
5. Effects of cognitive behavioural therapy and bright light therapy in youth with unipolar depression and evening chronotype: An assessor-blind, parallel-group, randomised controlled trial. Funded by General Research Fund, Research Grants Council. Capacity: Co-I. Study duration: 1/1/2023 – 30/6/2025.
6. Neuropsychiatric ‘long-COVID’ in adult patients. Funded by Collaborative Research Grant, Research Grants Council, Capacity: Co-I. Study duration: 10/5/2022-9/5/2024
7. Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 7-year prospective study. Funded by Health and Medical Research Fund –Food and Health Bureau. Capacity: Co-I. Study duration: 1/11/2022-31/10/2024
8. Digital mental health in depression – deep phenotyping and monitoring. Funded by Health and Medical Research Fund –Food and Health Bureau. Capacity: Co-I. Study duration: 4/7/2022-3/7/2024.
9. Prevention of insomnia in at-risk youth: A randomised controlled trial comparing cognitive behavioral prevention programme for insomnia with active control condition. Funded by General Research Fund, Research Grants Council. Capacity: Co-I. Study duration: 1/7/2021 – 31/12/2023.

1. Tang JH, Wing YK, Chan JWY*, Lo RSK.
   Bright Light Therapy for Cancer-related Fatigue in a Palliative Care Unit: A Feasibility Study.
   J Pain Symptom Manage.2023;65(3):e237-e40.
2. Feng H, Yang L, Liang YY, Ai S, Liu Y, Liu Y, Jin X, Lei B, Wang J, Zheng N, Chen X, Chan JWY, Sum RKW, Chan NY, Tan X, Benedict C, Wing YK, Zhang J.
   Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study.
   Nat Commun. 2023;14(1):930.
3. Chau SWH, Liu Y, Zhang J, Leung E, Chen S, Ho CL, Chan JWY, Tsang CC, Li SX, Huang B, Lam SP, Mok VC, Wing YK.
   Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study.
   Parkinsonism Relat Disord. 2023;107:105271.
4. Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, Zhang J, Chan PKS, Yeoh YK, Chen Z, Zhou L, Wong SH, Mok VCT, To KF, Lai HM, Ng S, Trenkwalder C, Chan FKL, Wing YK.
   Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives.
   Nat Commun. 2023 May 2;14(1):2501. doi: 10.1038/s41467-023-38248-4.
5. Chan JWY*, Chan NY, Li SX, Lam SP, Chau SWH, Liu Y, et al.
   Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.
   J Clin Sleep Med. 2022;18(2):523-31.
6. Chan JWY*, Li SX, Chau SWH, Chan NY, Zhang J, Wing YK.
   Prediction of Dropout in a Randomized Controlled Trial of Adjunctive Light Treatment in Patients with Non-Seasonal Depression and Evening Chronotype.
   Clocks & Sleep. 2022;4(3):346-57.
7. Chan JWY, Lam SP, Li SX, Chau SW, Chan SY, Chan NY, et al.
   Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial.
   Psychol Med. 2022;52(8):1448-57.
8. Chan JWY, Lam SP, Li SX, Yu MW, Chan NY, Zhang J, et al.
   Eveningness and insomnia: independent risk factors of nonremission in major depressive disorder.
   Sleep. 2014;37(5):911-7.

• Honorary Associate Consultant, New Territories East Cluster, Hospital Authority
• Vice President, The Chinese Dementia Research Association
• Council member, Hong Kong College of Psychiatrists
• Publications Committee member, Hong Kong College of Psychiatrists
• Editorial Board member, East Asian Archives of Psychiatry (EAAP)

• Best Poster Award, the 15th International Congress of the Asian Society Against Dementia (ASAD), Japan, 2021
• Distinguished Young Fellow, the Hong Kong Academy of Medicine, 2017
• Young Psychiatrists Fellowship Award, the ASEAN Federation of Psychiatry and Mental Health (AFPMH), 2014

• Epidemiology, prevention, early detection, and intervention for neurocognitive disorders
• Determinants of healthy aging
• Associations among physical, mental, and cognitive health

1. Can increasing participation in habitual intellectual activities enhance functional connectivity of default mode network in community-living Chinese adults with subjective cognitive decline? A randomized controlled trial.
   (Funded by Early Career Scheme, RGC 2019/2020. Capacity: PI. Ref. number: 24114519. Funding: $1,190,840. Study duration: 1/1/2020-31/12/2021)
2. Can whole-body vibration treatment optimize cognitive function in older adults who have sarcopenia and are at risk of dementia? A randomized controlled trial
   (Funded by HMRF. Capacity: PI. Reference number: 08190476. Funding: $1,386,977. Study duration: 17/12/2021-16/12/2023)
3. Structured frontal lobe based cognitive stimulation to older adults with subjective cognitive decline and comorbid depressive symptoms
   (Funded by CUHK Direct Grant for Research 2018/2019. Reference number: 2018.076. Capacity: PI. Funding: $149,947. Study duration: 30/6/2019-29/6/2022)
4. Health determinants for late onset dementia and its associated mortality in Hong Kong Chinese older adults.
   (Funded by HMRF Commissioned Study 2018. Ref. number: CFS-CUHK3. Capacity: Co-PI. PI: Linda Lam, Dept of Psychiatry, CUHK. Funding: $7,492,300. Study duration: 1/7/2019-30/6/2022)
5. Small Data Learning for Alzheimer’s Disease: From Digital Biomarker to Early Detection and Intervention
   (Funded by CRF. Capacity: Co-PI. Reference number: C4034-21GF. PI: Professor Guoliang Xing, Department of Information Engineering, CUHK. Funding: $8,230,720. Study duration: 1/1/2022-31/12/2024.)
6. Machine learning technologies for advancing digital biomarkers for Alzheimer’s Disease
   (Funded by the Alzheimer’s Drug Discovery Foundation. Capacity: Co-PI. Reference number: GDADB-201906-2019049. PI: Professor Guoliang Xing, Department of Information Engineering, CUHK. Funding: USD$641,204. Study duration: 1/7/2020-30/6/2023)
7. A 9-year follow-up of the Hong Kong Mental Morbidity Survey (HKMMS) on Chinese adults with depressive and anxiety symptoms.
   (Funded by HMRF Commissioned Study 2018. Ref number: CFS-CUHK4.Capacity: Co-I. PI: Professor Linda Lam, Department of Psychiatry, CUHK. Funding: $7,767,730. Study duration:1/7/2019-31/12/2023)
8. The Hong Kong Mental Morbidity Survey for Older People – MMSOP
   (Funded by HMRF Commissioned Study 2018. Ref. number: MHS-P1(Part 3)-CUHK. Capacity: Co-I. PI: Professor Linda Lam, Department of Psychiatry, CUHK. Funding: $17,289,625. Study duration: 1/1/2019-31/12/2022)
9. Combining mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment: a randomized controlled trial
   (Funded by HMRF 2017. Capacity: Co-I. Reference number: 16170421. PI: Professor Samuel Wong, School of Public Health and Primary Care, CUHK. Funding: $1,499,589. Study duration: 16/9/2019-15/3/2024)
10. Mortality among older persons with schizophrenia in Hong Kong
    (Funded by HMRF. Capacity: Co-I. Reference number: 18192331. PI: Dr. WC Chan, Department of Psychiatry, HKU. Funding: $732,624. Study duration: 3/1/2022-2/1/2024)
11. Circulating cell-free mitochondrial DNA as marker for early detection of cognitive decline in elderly
    (Funded by HMRF. Capacity: Co-I. Reference number: 09200246. PI: Dr. SL Ma, Department of Psychiatry, CUHK. Funding: $1,446,240. Study duration: 15/7/2022-14/7/2025)
12. Novel MRI-based machine learning tool to detect mild cognitive impairment associated with Alzheimer’s disease
    (Funded by HMRF. Capacity: Co-I. Reference number: 08190666. PI: Dr. Ho Ko, CUHK. Funding: $911,140. Study duration: 5/2/2022-4/2/2024)
13. The role of big data in addressing the determinants of non-communicable diseases in the ageing era – collaboration between CUHK and Worldwide Universities Network (WUN) partners
    https://wun.ac.uk/wun/research/view/the-role-of-big-data-in-addressing-the-determinants-of-non-communicable-diseases-in-the-ageing-era
    http://www.oal.cuhk.edu.hk/201909-41-cuhk-wun/
14. Computer Use for Seniors on Mood Improvement and Logic Enhancement (CU-SMILE)
    (Funded by Knowledge Transfer Project Fund (KPF), and Social Innovation and Entrepreneurship Development Fund (SIE Fund) of the Government of HKSAR: $399,996, Capacity: Allen as PI, Linda as Co-I
    Study Duration: 1 April 2024 to 31 March 2026)

1. Lee ATC, Mok VCT, Lam LCW.
   How do we measure mood and behavioural symptoms across the stages of dementia?
   In Chapter 12 of World Alzheimer Report 2022. Published by Alzheimer’s Disease International in September 2022.
2. Lai VKY, Fung AWT, Lam LCW, Lee ATC.
   Is sleep quality a potential predictor of neurocognitive disorders? A 6-year follow-up study in Chinese older adults.
   International Journal of Geriatric Psychiatry. 2022 Aug;37(8).   
3. Lee ATC, Chiu HFK, Peisah C.
   Clinical considerations when using assessment tools to identify depression in older adults with mild cognitive impairment.
   International Psychogeriatrics. 2022 May;34(5):413-416.
4. Lam LCW, Lee ATC.
   Is cognitive screening useful for long-term prediction of incident dementia?
   The Lancet Healthy Longevity. 2021 July 1;2(7):e387-e388.
5. Lee ATC, Fung AWT, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Risk of incident dementia varies with different onset and courses of depression.
   Journal of Affective Disorders. 2021 Mar 1;282:915-920.
6. Lee ATC, Mo FYM, Lam LCW.
   Higher psychogeriatric admissions in COVID-19 than in severe acute respiratory syndrome.
   International Journal of Geriatric Psychiatry. 2020 Dec;35(12):1449-1457.
7. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Higher dementia incidence in older adults with poor visual acuity.
   The Journals of Gerontology: Series A, Biological Sciences and Medical Sciences. 2020 Oct 15;75(11):2162-2168.
8. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Association of daily intellectual activities with lower risk of incident dementia among older Chinese adults.
   JAMA Psychiatry. 2018 Jul 1;75(7):697-703.
9. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
   Lower risk of incident dementia among Chinese older adults having three servings of vegetables and two servings of fruits a day.
   Age and Ageing. 2017;46(5):773 –779.
10. Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
    Intensity and types of physical exercise in relation to dementia risk reduction in community-living older adults.
    Journal of the American Medical Directors Association. 2015;16(10): 899.e1 –7.

Guest Editor for:

• Age and Ageing
• Alzheimer’s & Dementia
• Alzheimer’s & Dementia: Translational Research & Clinical Interventions
• Behavioral Sleep Medicine
• BJPsych Open
• BMC Geriatrics
• BMJ Open
• Frontiers in Dementia
• Frontiers in Psychiatry
• International Psychogeriatrics
• Stress & Health

Supervised over 10 Master and PhD students at CUHK

Serving as a mentor for GPS Medical Students at CUHK

• Associate Director, The Hong Kong Jockey Club Centre for Suicide Research and Prevention
• Honorary Associate Professor, School of Chinese, The University of Hong Kong
• Honorary Treasurer of the Hong Kong College of Psychiatrists
• College Spokesman of the Hong Kong College of Psychiatrists
• Member of the Task Force on Social Media of the Professionalism and Ethics Committee of the Hong Kong Academy of Medicine
• Honorary Consultant, New Territories East Cluster, Hospital Authority

Youth Mental Health, Digitalization and Human Mind, Culture and Psychiatry, Music and Mental Health, Cantopop and Well-being, Medical Humanities and Ethics, Addiction and Internet Addiction, Mental Health Promotion and Anti-stigmatization

1. Chan, K.T. (2022).
   Emergence of the ‘Digitalized Self’ in the Age of Digitalization.
   Computers in Human Behavior Reports, 6: 100191.
2. 陳啓泰（編著）(2024)。
   多謝廣東歌 讓我好好過。
   香港：商務印書館(香港)有限公司
3. Chan K.T., Law C.W., Chen E.Y.H. (2024).
   Developing the Youth Mental Health Clinic in Hong Kong: refocus and revisit of clinical practice for youth in the new millennium.
   East Asian Archives of Psychiatry, 34:37-42.
4. Chen, E.Y.H., Hui, C.L.M., Lam, M.M.L., Chiu, C.P.Y., Law, C.W., Chung, D.W.S., Tso, Chan K.T., et al. (2010).
   Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial.
   British Medical Journal.
5. Lam Y.H., Hui C.L.M., Lui S.Y.S., Chan K.T., Wong M.T.H., Chan K.W., Lee H.M.E., Chang W.C., Wong G.H.Y. and Chen E.Y.H. (2021).
   LevelMind @ JC hubs–a novel community‐based youth mental wellness early intervention in Hong Kong: An evaluation of stakeholders’ perceptions and experiences.
   Early Intervention in Psychiatry.
6. WONG M.Y.S., Lam Y.H., Wong S.M.C., Lee P.Y.H., Wong G.H.Y., Lui S.Y.S., Chan K.T., Wong M.T.H., Chan K.W., Chang W.C., Lee H.M.E., Suen Y.N., Hui C.L.M. and Chen E.Y.H. (2021).
   Measuring subjective stress among young people in Hong Kong: validation and predictive utility of the single-item subjective level of stress (SLS-1) in epidemiological and longitudinal community samples.
   Epidemiology and Psychiatric Sciences, 30.
7. Wong M.Y.S., Chen E.Y.H., Wong S.M.C., Suen Y.N., Chan D.L.K., Tsang H.S.S., Wong T.Y., Cheung C., Chan K.T., Lui S.Y.S., Wong M.T.H., Chan K.W., Lee H.M.E., Myin-Germeys I.N.E.Z. and Hui C.L.M. （2022).
   Impact of smartphone overuse on 1-year severe depressive symptoms and momentary negative affect: Longitudinal and experience sampling findings from a representative epidemiological youth sample in Hong Kong.
   Psychiatry Research, 318, 114939.
8. Wong M.Y.S., Ip H., Hui C.L.M., Suen Y.N., Wong S.M.C., Chang W.C., Chan K.W., Lee H.M.E., Lui S.Y.S., Chan K.T., Wong M.T.H. and Chen E.Y.H. (2022).
   Prevalence and correlates of suicidal behaviours in a representative epidemiological youth sample in Hong Kong: the significance of suicide-related rumination, family functioning, and ongoing population-level stressors.
   Psychological Medicine, 1-11.
9. Wong, S.M.Y., Chen, E.Y.H., Suen Y.N., Chan K.T., et al.  (2023).
   Increased psychological distress among young people before and during the fifth wave of COVID-19 after two years of pandemic in Hong Kong: a 6-month longitudinal study.
   BMC Psychiatry, 23.
10. 陳啓泰（作者）(2019)。
    《香港詞人系列》向雪懷。
    香港：中華書局(香港)有限公司

• Computational modelling of abnormal decision making processes in neuropsychiatric and neurodegenerative disorders
• Data-driven decision making in clinical management of neuropsychiatric and neurodegenerative disorders
• Multi-modal neuroimaging
• Neuropsychiatric disorders associated with Coronavirus (SARS/COVID)
• Novel approach in medical education

1. Prediction of 5-year risk of neurodegeneration in patients with idiopathic REM sleep behavior  disorder from multimodal neurodegenerative markers using deep neural network
2. Decision making in patients with idiopathic REM sleep behavior disorder and its neurobiological correlate

1. Chau, S.W.H., Wong, O.W.H., Ramakrishnan, R. et al.
   History for some or lesson for all? A systematic review and meta-analysis on the immediate and long-term mental health impact of the 2002–2003 Severe Acute Respiratory Syndrome (SARS) outbreak.
   BMC Public Health 2021 Apr 7;21(1):670.
2. Phiri P, Ramahrishnan R, Rathod S, Elliot K, Thayanandan T, Sandle N, Haque N, Chau SWH, Wong OWH, Chan SSM, Wong EKY, Raymont V, Kingdon D, Delanerolle GKE.
   An evaluation of the mental health impact of SARS-Cov-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis.
   EClinicalMedicine.2021 Apr;34:100806.
3. Chau, SWH.
   Antagonistic or inflexible? Exploring the underpinnings of ‘impulse dyscontrol’.
   International Psychogeriatrics, 2021 May 21;1-6.
4. H.J. Hopman, S.M.S. Chan, W.C.W. Chu, H. Lu, C.-Y. Tse, S.W.H. Chau, L.C.W. Lam, A.D.P. Mak, S.F.W. Neggers.
   Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning,
   Journal of Affective Disorders, 2021 Jul 1;290:261-271
5. Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SWH, Chen J, Tan X, Jia F, Tang X, Shi J, Lu Lin, Wing YK.
   Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
   European Heart Journal. 2021 Sep 7;42(34):3349-3357
6. Feng H, Chen L, Liu, Y, Chen, X, Wang J, Yu MW, Huang B, Li SX, Chau SWH, Chan JW, Chen, J, Mok VC, Wing YK and Zhang J.
   Rest‐activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Ann Neurol. 2020 Oct;88(4):817-829
7. Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JWY, Li SX, Huang B, Feng H, Mok V, Wing YK.
   Residual Injurious Symptoms and Its Association with Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-Up Study.
   Mov Disord. 2020 Nov;35(11):2077-2085
8. Chau SWH, Lewis T, Ng R, Chen JY, Farrell SM, Molodynski A, Bhugra D Wellbeing and mental health amongst medical students from Hong Kong. International Review of Psychiatry, Nov-Dec 2019;31(7-8):626-629
9. Molodynski A, Lewis T, Kadhum M, Farrell SM, Chelieh ML, De Almeida TF, Masri R, Kar A, Volpe U, Moir F, Torales J, Castaldelli-Maia JM, Chau SWH, Wilkes C, Bhugra D (2020).
   Cultural variations in wellbeing, burnout and substance use amongst medical students in twelve countries.
   International Review of Psychiatry, Feb-Mar 2021;33(1-2):37-42
10. Chau SW, Tse CY, So SH, Chan SS
    Attentional Bias Modification Training for Patients with Generalised Anxiety Disorder: a Randomised Controlled Study.
    East Asian Arch Psychiatry, 2019 Mar;29(1):3-9.

• Member of Editorial Board, East Asian Archives of Psychiatry (Official Journal of the Hong Kong College of Psychiatrists)
• Member, Special interest group in Clinical Neuroscience, The Hong Kong College of Psychiatrists
• Member, Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee
• Member, University Health Service Committee, The Chinese University of Hong Kong

• Autism spectrum disorder
• Child and adolescent mental health
• Microbiota-gut-brain axis
• Neurocognitive function and assessment
• Mobile-phone app base intervention for mental health

1. Hong Kong Child and Adolescent Psychiatric Epidemiologic Survey: Age 6 to 17
   (Funded by HMRF Commissioned Study 2018; Capacity: Co-I; PI: Prof. SF Hung, Department of Psychiatry, CUHK)
2. Gastrointestinal dysbiosis among autism boys without functional gastrointestinal disorder: a metagenomics and case-control study
   (Funded by Funded by CUHK Direct Grant for Research 2020/2021; Capacity: PI)
3. Visualization of clinical psychiatry: development of a series of annotated online teaching videos on mental state examination
   (Funded by Teaching Development and Language Enhancement Grant (TDLEG) for 2019-22; Capacity: Principal Supervisor)
4. Mobile-phone-based Intervention for Caregivers of Adolescents – Empowerment Through Mindfulness-based and Empathy-guided Continuous Learning and Support Programme
   (Funded by Mental Health Initiatives Funding Scheme Phase 1; Capacity: PI)

1. Wong, O. W., Barzilay, R., Lam, A. M., Chan, S., Calkins, M. E., Gur, R. E., & Gur, R. C. (2022).
   Executive function as a generalized determinant of psychopathology and functional outcome in school-aged autism spectrum disorder: a case-control study.
   Psychological Medicine, 1-11.
2. Wong, O. W., Lam, A. M., Or, B. P., Mo, F. Y., Shea, C. K., Lai, K. Y., … & Leung, P. W. (2022)
   Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case–control study on prepubertal Chinese boys.
   Scientific reports, 12(1), 1-13.
3. Wong, O. W., Lam, A. M., Lai, K. Y., Ma, S. L., Hung, S. F., Chan, S., Wong, S. Leung, P. W. (2021).
   An elevated anxiety level among prepubertal autistic boys with non‐treatment‐seeking functional gastrointestinal disorders: A case–control study.
   Autism Research,2021 Oct;14(10):2131-2142.
4. Hopman, H. J., Choy, H. Y., Ho, W. S., Lu, H., Wong, W. H. O., Chan, S. M. S. (2021).
   The Effects of Repetitive Transcranial Magnetic Stimulation Antidepressant Response on Cold Cognition: A Single-Arm Prospective Longitudinal Study.
   Neuropsychiatric Disease and Treatment, 2021 May 26;17:1647-1658
5. Chau, S. W., Wong, O. W., Ramakrishnan, R., Chan, S. S., Wong, E. K., Li, P. Y., Raymont, V., Elliot, K., Rathod, S., Delanerolle, G., Phiri, P. (2021).
   History for some or lesson for all? A systematic review and meta-analysis on the immediate and long-term mental health impact of the 2002–2003 Severe Acute Respiratory Syndrome (SARS) outbreak.
   BMC public health, 2021 Apr 7;21(1):670.
6. Wong, O. W., Chan, A., Wong, A., Lau, C. K., Yeung, J. H., Mok, V., Chan, S. (2020).
   Prolonged visual fixation as a surrogate marker of cholinergic deficit in Parkinson’s disease: A 2-year follow-up study. Parkinsonism & Related Disorders, 2020 Dec;81:60-66.
7. Wong, O. W., Fung, G. P., Chan, S. (2019).
   Characterizing the relationship between eye movement parameters and cognitive functions in non-demented Parkinson’s disease patients with eye tracking.
   J Vis Exp. 2019 Sep 26;(151).
8. Wong, O. W., Chan, A. Y., Wong, A., Lau, C. K., Yeung, J. H., Mok, V. C., Lam, L. C., Chan, S. S (2018).
   Eye movement parameters and cognitive functions in Parkinson’s disease patients without dementia.
   Parkinsonism & related disorders, 2018 Jul;52:43-48

• Postdoctoral training at Department of Medicine, Harvard University

• 2005 Sir Edward Youde Memorial Fellowship

• Genetic susceptibility of neurodegenerative disorders, such as mild cognitive impairment and dementia
• Development of genetic markers for early detection of cognitive decline

1. Circulating cell-free mitochondrial DNA as marker for early detection of cognitive decline in elderly.
   (Funded by HMRF 2022; Capacity: PI)
2. Functional study of polymorphisms of inflammasome-related genes in Alzheimer’s disease.
   (Funded by CUHK Direct Grant 2022/2023. Capacity: PI)
3. Examining the genetic link of REM sleep behaviour disorder (RBD) and familial aggregation by whole exome sequencing (WES).
   (Funded by CUHK Direct Grant 2021/2022. Capacity: PI)
4. Mapping the Functional Significance of the Human Oxytocin Receptor Gene.(Funded by USYD-CUHK Partnership Collaboration Awards. Capacity: PI)
5. Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alpha- synucleinopathy Neurodegeneration, in a Prospective Family Cohort.
   (Funded by Collaborative Research Fund 2021/22; Capacity: Co-PI; PI: Prof YK Wing, Department of Psychiatry, CUHK)
6. Loneliness in Chinese older adults: Association with inflammation and cognitive decline. A 2-year longitudinal study.
   (Funded by GRF 2023/2024; Capacity: Co-I; PI: Dr Ada Fung, Department of Sport and Physical Education, HKBU)
7. Effect of a 6-week Integrated Attention Training Program on cognitive function in older adults with co-occurring anxiety symptoms and subjective cognitive complaints.
   (Funded by HMRF 2022; Capacity: Co-I; PI: Dr Ada Fung, Department of Sport and Physical Education, HKBU)
8. Family-based association study in idiopathic rapid eye movement sleep behavior disorder: a two-phase study using whole exome sequencing.
   (Funded by GRF 2022/2023; Capacity: Co-I; PI: Prof YK Wing, Department of Psychiatry, CUHK)
9. Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning.
   (Funded by GRF 2022/2023; Capacity: Co-I; PI: Prof Sandra Chan, Department of Psychiatry, CUHK)
10. Development of a Single Cell Full-Length Mitochondrial Sequencing Platform based on Droplet Microfluidics.
    (Funded by GRF 2022/2023; Capacity: Co-I; PI: Dr Megan Ho, Department of Biomedical Engineering, CUHK)
11. Depressive Symptom Dynamics among Adolescents with Clinical and Subthreshold
    Depression – The Role of Stress on Symptom Connectedness.
    (Funded by HMRF 2022; Capacity: Co-I; PI: Prof. Suzanne Ho, Department of Psychology, CUHK)
12. Hong Kong Child and Adolescent Psychiatric Epidemiologic Survey: Age 6 to 17 (Funded by HMRF Commissioned Study 2018; Capacity: Co-I; PI: Prof. SF Hung, Department of Psychiatry, CUHK)
13. The Hong Kong Mental Morbidity Survey for Older Persons.
    (Funded by HMRF Commissioned Study 2018; Capacity: Co-I. PI: Prof. Linda Lam, Department of Psychiatry, CUHK)
14. Health determinants for late onset dementia and its associated mortality in Hong Kong Chinese older adults.
    (Funded by HMRF Commissioned Study 2018. Capacity: Co-I. PI: Prof. Linda Lam, Department of Psychiatry, CUHK)

1. Ma SL, Tang KT, Lau NCT, Chiu CLH, Lin C, Lam LCW, Lee ATC.
   Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression – a pilot randomized controlled trial.
   Front Psychiatry. 2024 Jan 17;14:1287822.
2. Fung AWT, Lee ATC, Ma SL, Lam LCW.
   Development and validation of cognitive ageing risk score (CARS) for early detection of subtle cognitive deficits in older people.
   BMC Geriatr. 2024 Mar 21;24(1):277.
3. Huang B, Huang J, Chiang NH, Chen Z, Lui G, Ling L, Kwan MYW, Wong JSC, Mak PQ, Ling JWH, Lam ICS, Ng RWY, Wang X, Gao R, Hui DS, Ma SL*, Chan PKS, Tang NLS.
   Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients.
   Front Immunol. 2024 Jan 10;14:1315602. *Corresponding author.
4. Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, Zhang J, Chan PKS, Yeoh YK, Chen Z, Zhou L, Wong SH, Mok VCT, To KF, Lai HM, Ng S, Trenkwalder C, Chan FKL, Wing YK.
   Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives.
   Nat Commun. 2023 May 2;14(1):2501.
5. Yeung SSY, Ma SL, Wang X, Chen Y, Tsui SKW, Tang NLS, Woo J.
   Telomere Length among Chinese Aged 75+ Years.
   Gerontology. 2023;69(12):1414-1423.
6. Ma SL, Chen LH, Lee CC, Lai KYC, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL.
   Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene.
   Front Neurosci. 2021, 27; 15:649588.
7. Ma SL, Wu J, Zhu L, Chan RS, Wang X, Huang D, Tang NL, Woo J.
   Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia.
   Nutrients. 2021;13(7):2313.
8. Ma SL, Tang NLS, Lam LCW.
   Promoter methylation and gene expression of Pin1 is associated to the risk on Alzheimer’s disease in Southern Chinese.
   Curr Alz Res. 2020; 17 (13):1232-1237.
9. Lee KY, Leung KS, Ma SL, So HC, Huang D, Tang NLS, Wong MH.
   Genome-wide search for SNP interactions in GWAS data: algorithm, feasibility, replication using schizophrenia datasets.
   Front. Genet. 2020; 11:1003.
10. Ma SL, Tang NLS, Wat KHY, Tang JHY, Lau KH, Law CB, Chiu J, Tam CCW, Poon TK, Lin KL,Kng CPL, Kong HL, Chan TY, Chan WC, Lam LCW.
    Effect of CYP2D6 and CYP3A4 genotypes on the efficacy of cholinesterase inhibitors in Southern Chinese patients with Alzheimer’s Disease.
    Am J Alzheimers Dis Other Demen. 2019; 34(5):302-307.
11. Lu H, Ma SL, Wong SW, Tam CW, Cheng ST, Chan SS, Lam LC.
    Aberrant interhemispheric functional connectivity within default mode network and its relationships with neurocognitive features in cognitively normal APOE ε 4 elderly carriers.
    IntPsychogeriatr. 2017; 29(5):805-814.
12. Zhou L, Ma SL*, Yeung PKK , Wong YH,Tsim KWK, So KF, Lam LCW and Chung SK
    Anxiety and depression with neurogenesis defects in Exchange Protein Directly Activated by cAMP (Epac) 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.
    Transl Psychiatry. 2016; 6:e881. *Co-1st author
13. Chen HY, Ma SL*, Huang W, Ji L, Leung VH, Jiang H, Yao X, Tang NL.
    The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model.
    Sci Rep. 2016; 2;6:38225. *Co-1st author

• Deputy Director, Neuromodulation Clinic
• Mentor, CU Medicine Global Physician-Leadership Stream (GPS)
• Visiting Fellow: National Laboratory of Pattern Recognition, Chinese Academy of Sciences
• Honorary Professor: The Affiliated Brain Hospital of Guangzhou Medical University
• Associate Researcher: Shenzhen Research Institute (SZRI) CUHK (By Courtesy)
• Editorial Board Members:
  • BMC Medicine (2021-) (Springer Nature, 5-year IF: 10.249)
  • BMC Psychiatry (2020-) (Springer Nature, 5-year IF: 3.386)
  • General Psychiatry (GPSYCH) (2018-) (Springer Nature, 5-year IF: 6.2)
• Associate Editor:
  • Journal of Alzheimer’ Disease (2017-) (IOS Press, IF: 3.909)
  • Stroke & Vascular Neurology (2022-) (BMJ Press, IF: 4.4)

• Individualized non-invasive brain stimulation (NIBS)
• Computational models of brain age
• Managements of comorbidities in patients with cognitive impairments
• Mechanisms of cognitive ageing and resilience related to NIBS
• Artificial intelligence (AI)-driven approach to imaging in psychiatry

1. Multiscale neuroimaging-based data integration for mapping the radiomics of human brain, Research Data Management Development Fund, Capacity: PI. Study duration: 01/10/2024-30/09/2025.
2. Effects of high-definition transcranial random noise stimulation (tRNS) on sleep disturbances and cognition in mild vascular cognitive impairment: a pilot randomized controlled trial, Direct Grants for Research, The Chinese University of Hong Kong, Capacity: PI. Study duration: 24/06/2024-23/06/2025.
3. Radiomics for the Prediction of Brain Age, Cognitive Maintenance and Healthy Longevity Funded by Research Grants Council (RGC)-US. National Academy of Medicine (NAM). Capacity: PI. Study duration: 01/10/2023-30/09/2024.
4. Transcranial alternating current stimulation for mild neurocognitive disorders due to Alzheimer’s disease, Funded by Research Grants Council (RGC)-General Research Fund (GRF). Capacity: PI. Study duration: 01/01/2022-31/12/2023.
5. Developing the geometric model of network-based cortical complexity, Funded by National Laboratory of Pattern Recognition, Chinese Academy of Sciences (CAS). Ref. number: 202100034. Capacity: PI. Study duration: 01/2021-12/2022.
6. A novel computational framework for optimizing disease-specific transcranial brain stimulation model (Reference No.: 4054645), Funded by CUHK Direct Grant for Research. Capacity: PI. Study duration: 24/06/2021 – 23/06/2022.
7. Decoding the cognitive trajectory of Hong Kong SuperAgers: a six-year follow-up study, Funded by CUHK Direct Grant for Research. Ref. number: 4054569. Capacity: PI. Study duration: 25/06/2020-24/06/2021
8. LANDSCAPE 2.0: A Multimodal Neuroimaging Study (Funded by CUHK Direct Grant for Research 2018/2019. Ref. number: 4054495. Capacity: PI. Study duration: 24/06/2019-24/06/2020)
9. The Effects of virtual reality (VR) in the treatment of early-stage PIDG. National Natural Science Foundation of China (NSFC). Capacity: Co-I. Principal Investigator: Prof. MENG Lin, Tianjin University. Study duration: 01/01/2024-31/12/2025.
10. Effect of a six-week Integrated Attention Training Program on the cognitive functions of older adults with co-occurring anxiety symptoms and subjective cognitive complaints. HMRF. Capacity: Co-I. PI: Prof. FUNG Ada. Study duration: 2023-2026.
11. Personalized prediction of transcranial magnetic stimulation clinical response in patients with treatment-refractory depression using neuroimaging biomarkers and machine learning, Funded by Research Grants Council (RGC)-General Research Fund (GRF). Capacity: Co-I. PI: Prof. Sandra Sau Man Chan, CUHK.
12. Transcranial Direct Current Stimulation in Post-Stroke Fatigue: A Double-blind Randomised Control Trial, Funded by Research Grants Council (RGC)-General Research Fund (GRF). Capacity: Co-I. PI: Prof. Wai Kwong Tang, CUHK.
13. Can increasing participation in habitual intellectual activities enhance functional connectivity of default mode network in community-living Chinese adults with subjective cognitive decline? A randomized controlled trial. (Funded by Early Career Scheme, RGC 2019/2020. Capacity: Co-I. PI: Dr. Allen Lee, CUHK. Ref. number: 24114519. Study duration: 1/1/2020-31/12/2021)

• 2024 PhD International Mobility for Partnerships and Collaborations Award (IMPAC Award) (PhD student: LI, Zeyan)
• 2024 Travel Awards, The 64th Annual Meeting of the Japanese Society of Neurology (JSN)
• 2023 Healthy Longevity Catalyst Awards (Hong Kong)
• 2022 Travel Awards, The 63rd Annual Meeting of the Japanese Society of Neurology (JSN)
• 2021 Best Paper Awards, China Association of Gerontology and Geriatrics (CAGG)
• 2021 Gold Award on the 19th Asian Oceanian Congress of Neurology (AOCN)
• 2021 Fellowship from Japanese Society of Radiology (JSR)
• 2021 Young Education Scholarship (YES) Awards on the 19th Asian Oceanian Congress of Radiology (AOCR)
• 2020 Travel Grants on the 61st Annual Meeting of the Japanese Society of Neurology (JSN)
• 2019 Best Paper Awards, China Association of Gerontology and Geriatrics (CAGG)
• 2019 Travel Grants on the 60th Annual Meeting of the Japanese Society of Neurology (JSN)
• 2019 Travel Grants on the 3rd International Taiwanese Congress of Neurology (ITCN) & Annual Meeting of Taiwan Neurological Society
• 2019 Training Fellowships from the National Institute for Physiological Sciences (NIPS) (Japan)
• 2018 Champion & Young Investigator Awards on the International Alzheimer’s Disease Conference
• 2018 Young Investigator Awards on The 15th Meeting of the Asian-Pacific Society for Neurochemistry
• 2015 Performance Award on the 22nd International Student Congress of [Bio] Medical Sciences 2015
• 2015 Paper Award on the 15th Congress of Chinese Cerebrovascular Diseases
• 2015 Paper Award on “Putting Aging Research and Clinical Practice in Cultural Context”: US-Hong Kong Conference

1. Lu H*, Li J, Ni X.
   Promoting Resilience in the Age of COVID-19 Pandemic: A New Era of Strategic Foresight.
   Aging and Disease 2021; 12(1): 1-2.
2. Lu H*.
   Caution of variability: Domain-specific cognition measured by Montreal Cognitive Assessment in normal ageing and prodromal dementia.
   International Journal of Geriatric Psychiatry 2020; 35(6), 686-687.
3. Lu H*, Lam LC.
   Associations between intra-individual variability and Montreal Cognitive Assessment (MoCA) in cognitive ageing and prodromal dementia: A domain-specific perspective.
   Parkinsonism & Related Disorders 2018; 48:102-103.
4. Lu H*, Lam LC.
   Impacts of ‘two-level’ variability on the differential power for Montreal Cognitive Assessment (MoCA) in prodromal dementia.
   Journal of Neurology, Neurosurgery and Psychiatry 2017; 88(2): 186-187.
5. Lu H*, Chan SS, Lam LC.
   ‘Two-level’ measurements of processing speed as cognitive markers in the differential diagnosis of DSM-5 mild neurocognitive disorders (NCD).
   Scientific Reports 2017; 7.
6. Lu H*.
   Intra-and inter-individual variability of information processing speed in adults with neurocognitive disorders.
   F1000 Research 2017; 6.
7. Lu H*, Chan SS, Fung AW, Lam LC.
   Utility of Montreal Cognitive Assessment (Hong Kong Version) in the diagnosis of mild neurocognitive disorders (NCD): NCD due to Alzheimer Disease (NCD-AD) and NCD due to Vascular Disease (NCD-Vascular).
   Journal of the American Medical Directors Association 2016; 17(4): 366
8. Lu H, Fung AW, Chan SS, Lam LC.
   Disturbance of attention network functions in Chinese healthy older adults: an intra-individual perspective.
   International Psychogeriatrics 2016; 28(2): 291-301.
9. Lu H*, Chan SS, Fung AW, Lam LC.
   Efficiency of attentional components in elderly with mild neurocognitive disorders shown by the attention network test.
   Dementia and Geriatric Cognitive Disorders 2016; 41(1-2): 93-98.
10. Lu H*, Law WY, Fung AW, Lam LC.
    Evaluating the Montreal Cognitive Assessment (MoCA) and its subtests for DSM-5 mild neurocognitive disorders (NCD): Does age have an effect on the screening accuracy?
    Journal of Psychosomatic Research 2016; 85: 26-27.
11. Lu H*, Chan SS, Lam LC.
    Associations between intra-Individual variability of reaction time and cognitive function in cognitively normal senior adults: still beyond good or bad?
    Geriatrics 2016; 1(2): 13.
    

1. Lu H*, Li J.
   MRI-informed machine learning-driven brain age models for classifying mild cognitive impairment converters.
   Journal of Central Nervous System Disease, 16, 11795735241266556.
2. Li, J., & Lu, H*.
   MRI-informed cortical features for brain age prediction in age‐specific adulthoods.
   Human Brain Mapping 2023, 44(2), 301.
3. Lu H*.
   Quantifying Age-Associated Cortical Complexity of Left Dorsolateral Prefrontal Cortex with Multiscale Measurements.
   Journal of Alzheimer’s Disease 2020; 76(2): 505-516.
4. Lu H*, Ma SL, Wong SW, Tam CW, Cheng ST, Chan SS, Lam LC.
   Aberrant interhemispheric functional connectivity within default mode network and its relationships with neurocognitive features in cognitively normal APOE ε 4 elderly carriers.
   International Psychogeriatrics 2017; 29(5): 805-814.
5. Lu H*.
   Mapping the brain: the leading projects of brain science in the era of big data (in Chinese).
   Chinese Journal of Psychiatry 2017; 50(2):157-160.
6. Lu H*, Ma SL, Chan SS, Lam LC.
   The effects of apolipoprotein ε 4 on aging brain in cognitively normal Chinese elderly: a surface-based morphometry study.
   International Psychogeriatrics 2016; 28(9): 1503-1511.
7. Lu H*, Ning YP.
   When neuroscience meets network thinking: new perspective on brain disorders (in Chinese).
   Chinese Journal of Neuromedicine 2014; 13(12): 1292-1296.
8. Lu H*, Ning YP.
   Advances in brain activity mapping (BAM) and brain connectome (in Chinese).
   Chinese Journal of Psychiatry 2014; 47(3): 179-182.
   

1. Lu H*, Li J, Yang NS, Lam LCW, Ma SL, Wing YK, Zhang, L.
   Using gamma-band transcranial alternating current stimulation (tACS) to improve sleep quality and cognition in patients with mild neurocognitive disorders due to Alzheimer’s disease: A study protocol for a randomized controlled trial.
   PLoS ONE 2023, 18(8), e0289591.
2. Lu H, Chan SS, Chan WC, Lin CC, Cheng PW, Lam LC.
   Randomised Controlled Trial of TDCS on Cognition in 201 Seniors with Mild Neurocognitive Disorder.
   Annals of Clinical and Translational Neurology 2019; 6(10): 1938-1948.
3. Lu H*, Lam LC, Ning YP.
   Toward Personalized Brain Stimulation: Advances and Challenges.
   CNS Neuroscience & Therapeutics 2019; 25(11): 1219-1221.
4. Lu H*, Lam LCW.
   Cathodal skin lesions induced by transcranial direct current stimulation (tDCS).
   Neuromodulation: Technology at the Neural Interface 2019; 22(8), 989-991.
5. Lu H*, Chan SS, Lam LC, Cheng CP, Chan WC, He HB, Zhao SH, Ning YP.
   Towards individualized psychiatric practice: the legacy of neurotherapeutics (in Chinese).
   Chinese Science Bulletin 2018; 63: 2592-2598.

1. Lu H*, Li J, Fung AWT, Lam LCW.
   Diversity in verbal fluency performance and its associations with MRI‐informed brain age matrices in normal ageing and neurocognitive disorders.
   CNS Neuroscience & Therapeutics 2023; 29(7): 1865-1880.
2. Lu H*, Xi N, Fung AW, Lam LC.
   Mapping the Proxies of Memory and Learning Function in Senior Adults with High-performing, Normal Aging and Neurocognitive Disorders.
   Journal of Alzheimer’s Disease 2018; 64(3): 815-826.
3. Lu H*, Chan SSM, Fung AWT, Lam LCW.
   Beyond a Differential Diagnosis: Cognitive and Morphometric Decoding of Information Processing Speed in Senior Adults with DSM-5 Mild Neurocognitive Disorders.
   Journal of Alzheimer’s Disease 2017; 58(3): 927-937.

1. Lu H*, Li J, Chan SSM, Ma SL, Mok VCT, Shi L, & Lam LCW. (2024).
   Predictive values of pre-treatment brain age models to rTMS effects in neurocognitive disorder with depression: Secondary analysis of a randomised sham-controlled clinical trial.
   Dialogues in Clinical Neuroscience, 26(1), 38-52.
2. Lu H*, Li J, Zhang L, Meng L, Ning Y, Jiang T.
   Pinpointing the precise stimulation targets for brain rehabilitation in early-stage Parkinson’s disease.
   BMC Neuroscience 2023, 24(1), 1-12.
3. Lu H*, Li J, Chan SSM, Yue WWY, Lam LCW.
   Decoding the radiomic features of dorsolateral prefrontal cortex in individuals with accelerated cortical changes: implications for personalized transcranial magnetic stimulation.
   Journal of Medical Imaging 2023, 10(1), 015001-015001.
4. Lu, H*., Chan, S. S. M., Ma, S., Lin, C., Mok, V. C. T., Shi, L., & Lam, L. C. W.
   Clinical and radiomic features for predicting the treatment response of repetitive transcranial magnetic stimulation in major neurocognitive disorder: Results from a randomized controlled trial.
   Human Brain Mapping 2022, 43(18), 5579-5592.
5. Lu, H*.
   Radiomics-informed modeling for transcranial ultrasound stimulation: Age matters.
   Frontiers in Neuroscience 2022, 924.
6. Lu, H*.
   MRI-Based Geometric Modeling for Personalized Transcranial Magnetic Stimulation in Age-Related Neurodegenerative Diseases.
   Frontiers in Neuroscience 2021, 860.
7. Lu H*, Li J, Zhang L, Chan SSM, Lam LCW.
   Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling.
   Journal of NeuroEngineering and Rehabilitation 2021, 18(1): 1-12..
8. Lu H*.
   Developing and aging: A tale of two stages.
   CNS Neuroscience & Therapeutics 2020; 26(2), 281.
9. Lu H*, Chan SS, Lam LC.
   Localized Analysis of Normalized Distance from Scalp to Cortex And Personalized Evaluation (LANDSCAPE): Focusing on Age-and Dementia-specific Changes.
   Journal of Alzheimer’s Disease 2019, 64(7): 1331-1341.
10. Lu H*, Lam LC, Ning YP.
    Scalp to Cortex Distance of Left Primary Motor Cortex and Its Computational Head Model: Implications for Personalized Neuromodulation.
    CNS Neuroscience & Therapeutics 2019; 25(11): 1270-1276.

• Chair, The Neuromodulation Society in Greater Bay Area, since 06/2024
• Committee Member, Brain mapping group, China Image Graphics Society (CSIG), since 11/2021
• Committee Member, Brain Connects, since 07/2019
• Member, IEEE Brain, since 05/2020
• Member, International Neuromodulation Society, since 10/2018
• Member, International Parkinson and Movement Disorder Society, since 08/2018
• Member, The Chinese Neuroscience Society, since 09/2017
• Member, Asian Society Against Dementia, since 09/2016
• Member, International Psychogeriatric Association, since 09/2015
• Member, Organization for Human Brain Mapping, since 05/2012

• Sleep and Psychopathology 
• Psychotherapy for Sleep and Mood Problems 
• Transdiagnostic Approach 
• Digital Mental Health 
• Stepped Care Model 
• Long covid 

• Travel Grant Award for Young Investigators in 2nd Congress of Asian Society of Sleep Medicine, Seoul, Korea, 2018 
• International Pediatric Sleep Association Online Young or New Investigator Poster Award, 2021 
• 3rd Congress of Asian Society of Sleep Medicine Young Investigator Award, 2021

• Motivational Interviewing Network of Trainers

1. Title: Advancing adolescent bedtime by using motivational interviewing and text reminders – A randomized controlled trial. Project period: 1/7/2018 – 30/6/2020
   Funding source: Health and Medical Research Fund
   Position: PI
2. Title: Effects of group-based and digitally delivered cognitive behavioural therapy for insomnia (CBT-I) in youth: a randomised controlled trial.
   Project period: 01/01/2021 – 31/12/2022
   Funding source: GRF
   Position: Co-I 
3. Title: Randomised controlled study to examine the efficacy of sleep education on extending sleep duration of preschool children. 
   Project period: 01/01/2021 – 31/12/2022
   Funding source: GRF
   Position: Co-I
4. Title: Prevention of insomnia in at-risk youth: A randomized controlled trial comparing cognitive behavioral prevention program for insomnia with active control condition.  
   Study period: 01/01/2022 -31/12-2023
   Funding source: GRF
   Capacity: PI
5. Title: understanding the relationship between stress, resilience and sleep problems in adolescents
   Study period: 30/06/2021 – 29/06/2022
   Funding source: Direct grant
   Capacity: PI
6. Title: Efficacy of group cognitive behavioural therapy for youth anxiety and insomnia: A randomised, assessor blind, parallel-group trial
   Project period: 01/01/2022 – 31/12/2023
   Funding source: GRF
   Position: Co-I
7. Title: Novel strategies to facilitate early detection, prevention and Intervention for long-Term Health problems related to COVID-19 (NovITor-COVID study)
   Project period: 01/04/2021 – 31/03/2026
   Funding source: HMRF Commission research
   Position: Co-I
8. Title: Neuropsychiatric ‘Long COVID’ in adult patients
   Project period: 05/2022 – 05/2023
   Funding source: CRF
   Position: Co-PI  
9. Title: Sleep intervention – A brief online sleep intervention tailored to South Asian population in Hong Kong.
   Project period, 1/4/2024 to 30/09/2025
   Funding source: Knowledge transfer fund ($400,000)
   Position: PI

1. Chen CX, Li TMH, Zhang J, Li SX, Yu MWM, Tsang CC, Chan KCC, Au TC, Li AM, Kong APS, Chan JWY, Wing YK, Chan NY.
   The impact of sleep-corrected social jetlag on mental health, behavioral problems, and daytime sleepiness in adolescents.
   Sleep Medicine, 2022:100, 494-500.
2. Chan NY, Lam SP, Zhang J, Chan JWY, Yu MWM, Suh S, Yang CM, Okajima I, Li AM, Wing YK, Li SX.
   Efficacy of Email-delivered vs. Face-to-face Group Cognitive Behavioral Therapy for Insomnia in Youths: A Randomized Controlled Trial.
   Journal of Adolescent Health, 2022;70: 763-773
3. Chan NY, Li SX, Zhang J, Lam SP, Kwok APL, YU MWM, Chan JWY, Li AM, Morin CM, Wing YK.
   A prevention program for insomnia in at-risk adolescents: a randomized controlled study.
   Pediatrics. 2021;147(3):e2020006833
4. Chan NY, Zhang J, Tsang CC, Li AM, Chan JWY, Wing YK, Li SX.
   The associations of insomnia symptoms and chronotype with daytime sleepiness, mood symptoms and suicide risk in adolescents.
   Sleep Medicine 2020;74:124-31.
5. Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK.
   Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects.
   Sleep Medicine. 2019; 53: 1-8.
6. Li SX, Chan NY, Man Yu MW, Lam SP, Zhang J, Yan Chan JW, Li AM, Wing YK.
   Eveningness chronotype, insomnia symptoms, and emotional and behavioural problems in adolescents.
   Sleep Medicine. 2018; 47: 93-9
7. Chan NY, Zhang J, Yu MWM, Lam SP, Li SX, Kong APS, Li AM, Wing YK.
   Impact of a modest delay in school start time in Hong Kong school adolescents.
   Sleep Medicine. 2017; 30: 164-70.
8. Zhang J, Chan NY, Lam SP, Li SX, Liu Y, Chan JW, Kong AP, Ma RC, Chan KC, Li AM, Wing YK.
   Emergence of Sex Differences in Insomnia Symptoms in Adolescents: A Large-Scale School-Based Study.
   Sleep. 2015; 39: 1563-70.
9. Chan NY, Lam SP, Zhang J, Yu MWM, Li SX, Li AM, & Wing YK.
   Sleep education in Hong Kong.
   Sleep Biological Rhythm. 2015; 14: 21-5.
10. Wing YK, Chan NY, Yu MWM, Lam SP, Zhang J, Li SX, Kong AP, Li AM.
    A school-based sleep education program for adolescents: a cluster randomized trial.
    Pediatrics. 2015; 13: e635-43.

Assistant Professor of Imaging and Interventional Radiology (Joint appointment)

Technical development

• Clinical decision support using artificial intelligence
• Image reconstruction

Applied research

• Stroke recovery mechanism
• Brain modelling using graph neural network

• Neuroarchitectural underpinning of stroke recovery
• Prediction of stroke outcome
• Chest X-ray report generation

https://www.ncbi.nlm.nih.gov/myncbi/14K0gzqiw9k/bibliography/public/

• Artificial intelligence and digital mental health
• Natural language processing for mental health
• Technology, electronics, and mental health
• Social withdrawal and psychological well-being

• INFORMS ISS Design Science Award 2020

1. Multimodal digital speech analysis for detection of depressive symptomatology in youth
   (Funded by Health and Medical Research Fund, Health Bureau. Capacity: PI. Project period:  2024-2027)
2. Passive sensing and detection of mood features using affective computing technology
   (Funded by IdeaBooster Fund, CUHK. Capacity: PI. Project period:  2024-2025)
3. Utilizing generative artificial intelligence (AI), deep learning, and prompt engineering for the development of digital depression assessment
   (Funded by Direct Grant for Research, CUHK. Capacity: PI. Project period:  2024-2025)
4. An intelligent coaching system for insomnia: Towards the next-generation digital intervention
   (Funded by Innovation and Technology Support Programme, Innovation and Technology Commission. Capacity: PI. Project period:  2024-2025)
5. Efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) with artificial intelligence chatbot for youth with insomnia: An assessor-blind, randomized controlled trial
   (Funded by General Research Fund, Research Grants Council. Capacity: PI. Project period:  2024-2026)
6. Development of automated speech-based suicidal ideation detection with artificial intelligence techniques
   (Funded by Direct Grant for Research, CUHK. Capacity: PI. Project period:  2023-2024)
7. Identifying suicide risk using natural language processing and machine learning of clinical interviews of depression
   (Funded by Direct Grant for Research, CUHK. Capacity: PI. Project period:  2022-2023)
8. An artificial intelligence chatbot for sleep education
   (Funded by Knowledge Transfer Project Fund, CUHK. Capacity: PI. Project period:  2022-2024)

1. Chen, J., Chan, N. Y., Li, C. T., Chan, J. W. Y., Liu, Y., Li, S. X., Chau, S. W. H., Leung, K. S., Heng, P.-A., Lee, T. M. C., Li, T. M. H., & Wing, Y. K. (2024).
   Multimodal digital assessment of depression with actigraphy and app in Hong Kong Chinese.
   Translational Psychiatry, 14, 150.
2. Huang, R., Yi, S., Chen, J., Chan, K. Y., Chan, J. W. Y., Chan, N. Y., Li, S. X., Wing, Y. K., & Li, T. M. H. (2024).
   Exploring the role of first-person singular pronouns in detecting suicidal ideation: A machine learning analysis of clinical transcripts.
   Behavioral Sciences, 14(3), 225.
3. Yu, D. J., Wing, Y. K., Li, T. M. H., Chan, N. Y. (2024).
   The impact of social media use on sleep and mental health in youth: A scoping review.
   Current Psychiatry Reports, 26(3), 104-119.
4. Li, T. M. H., Chen, J., Law, F. O. C., Li, C. T., Chan, N. Y., Chan, J. W. Y., Chau, S. W. H., Liu, Y., Li, S. X., Zhang, J., Leung, K. S., & Wing, Y. K. (2023).
   Detection of suicidal ideation in clinical interviews for depression using natural language processing and machine learning: Cross-sectional study.
   JMIR Medical Informatics, 11, e50221.
5. Li, T. M. H., Chan, N. Y., Li, C. T., Chen, J., Chan, J. W., Liu, Y., Li, S. X., Li, A. M., Zhang, J., & Wing, Y. K. (2022).
   The associations of electronic media use with sleep and circadian problems, social, emotional and behavioral difficulties in adolescents.
   Frontiers in Psychiatry, 13, 892583.
6. Chau, M., Li, T. M. H., Wong, P. W. C., Xu, J., Yip, P. S. F., & Chen, H. (2020).
   Finding people with emotional distress in online social media: A design combining machine learning and rule-based classification.
   Management Information Systems Quarterly, 44(2), 933-955.
7. Cheng, Q., Li, T. M. H., Kwok, C. L., Zhu, T., & Yip, P. S. F. (2017).
   Assessing suicide risk and emotional distress in Chinese social media: A text mining and machine learning study.
   Journal of Medical Internet Research, 19(7), e243.
8. Li, T. M. H., & Wong, P. W. C. (2015).
   Youth social withdrawal behavior (hikikomori): A systematic review of qualitative and quantitative studies.
   Australian and New Zealand Journal of Psychiatry, 49(7), 595-609.
9. Li, T. M. H., Chau, M., Yip, P. S. F., & Wong, P. W. C. (2014).
   Temporal and computerized psycholinguistic analysis of the blog of a Chinese adolescent suicide.
   Crisis: The Journal of Crisis Intervention and Suicide Prevention, 35(3), 168-175.
10. Li, T. M. H., Chau, M., Wong, P. W. C., Lai, E. S. Y., & Yip, P. S. F. (2013).
    Evaluation of a web-based social network electronic game in enhancing mental health literacy for young people.
    Journal of Medical Internet Research, 15(5), e80.

1. Gut microbiome dysbiosis in neurodegenerative diseases
2. Pathophysiology of REM sleep behavior disorder
3. Microbiota-targeted interventions, especially next-generation probiotics development
4. Gastrointestinal disorder and neurodegeneration

1)         Best Oral Presentation Award. Conference/organization: Sleep 2018, The Chinese University of Hong Kong, HK. Nov 2018.
2)         Travel Grant Winner in the RBDSG Symposium, 2019, Copenhagen, Demark

1. Characterization of nocturnal movement-related brain activity in REM sleep behavior disorder
2. Colonic dysfunction and gut microbiome dysbiosis at prodromal alpha-synucleinopathy – towards a better understanding of aetiology and pathogenesis

1. Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Zhang J, Ma SL, Chan PKS, Yeoh, YK, Chen Z, Wong, SH, Mok VCT, To KF, Wing YK, Lai HM, Ng S, Trenkwalder C, Chan FKL, Wing YK.
   Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives.
   Nature Communications 14(1): 2501.
2. Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y.
   Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.
   J Sleep Res. 2022;e13791.
3. Wang J, Chau SWH, Lam SP, Liu Y, Zhang J, Chan NY, Cheung MMS, Yu MWM, Tsang J, Chan JWY, Huang B, Li SX, Mok VCT, Wing YK.
   Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study.
   J Neurol Neurosurg Psychiatry. 2021;93(9)1010-1017.
4. Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MWM, Huang B, Li SY, Chau SWH, Chan JWY, Chen J, Mok VCT, Wing YK, Zhang JH.
   Rest-Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
   Ann Neurol. 2020;88(4):817-829.
5. Huang B, Qian Z, Wang Z, Zhang J, Chen K, Xu T, Wang J, Cechetto DF, Zhao Z, Wu H.
   Fluctuation of primary motor cortex excitability during cataplexy in narcolepsy.
   Ann Clin Transl Neurol. 2019;6(2): 210-221.

1. Ageing and neurodegenerative diseases
2. Mental health and telehealth
3. Health economics, cost of illness, and economic evaluation

1. Xiong, X., Luo, L., Zhou, S., Li V.L., Zhou, Y., Huo, Z. (2023).
   A profile of patients’ and doctors’ perceptions, acceptance, and utilization of e-health in a deprived region in southwestern China.
   PLOS Digit Health, 2(4): e0000238.
2. Xiong, Y., Huo, Z., Wong, S.Y.S., Yip, B.H.K. (2023).
   Cost effectiveness of nonpharmacological prevention programs for diabetes: a systematic review of trial-based studies.
   Chronic Diseases and Translational Medicine, 1-10.
3. Agyekum, S., Chan, P. P. , Zhang, Y., Huo, Z., Yip, B. H. K., Ip, P., Tham, C. C., Chen, L. J., Zhang, X. J., Pang, C. P., & Yam, J. C. (2023).
   Cost-effectiveness analysis of myopia management: A systematic review.
   Frontiers in public health, 11, 1093836.
4. Huo, Z., Lin, J., Bat, B. K. K., Chan, T. K., Yip, B. H. K., & Tsoi, K. K. F. (2022).
   Cost-effectiveness of pharmacological therapies for people with Alzheimer’s disease and other dementias: a systematic review and meta-analysis.
   Cost effectiveness and resource allocation: C/E, 20(1), 19.
5. Xiong, X., Li, J., Huang, B., Tam, T., Hong, Y., Chong, K. C., & Huo, Z. (2022).
   Economic Value of Vaccines to Address the COVID-19 Pandemic in Hong Kong: A Cost-Effectiveness Analysis.
   Vaccines, 10(4), 495.
6. Li, X., Huo, Z., Hu, Z., Lam, T. P., Cheng, J. C. Y., Chung, V. C., & Yip, B. H. K. (2022).
   Which interventions may improve bracing compliance in adolescent idiopathic scoliosis? A systematic review and meta-analysis.
   PloS one, 17(7), e0271612.
7. Huo, Z., Lin, J., Bat, B. K. K., Chan, J. Y. C., Tsoi, K. K. F., & Yip, B. H. K. (2021).
   Diagnostic accuracy of dementia screening tools in the Chinese population: a systematic review and meta-analysis of 167 diagnostic studies.
   Age and ageing, 50(4), 1093–1101.
8. Chan, J. Y. C., Bat, B. K. K., Wong, A., Chan, T. K., Huo, Z., Yip, B. H. K., Kowk, T. C. Y., & Tsoi, K. K. F. (2022).
   Evaluation of Digital Drawing Tests and Paper-and-Pencil Drawing Tests for the Screening of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies.
   Neuropsychology review, 32(3), 566–576.
9. Huo, Z., Chan, J. Y. C., Lin, J., Bat, B. K. K., Chan, T. K., Tsoi, K. K. F., & Yip, B. H. K. (2021).
   Supporting Informal Caregivers of People with Dementia in Cost-Effective Ways: A Systematic Review and Meta-Analysis.
   Value in health, 24(12), 1853–1862.
10. Huo, Z., Chan, J.Y., Lin, J., Bat, B.K.K., Chan, T.K., Tsoi, K.K. and Yip, B.H. (2021),
    Cost-effectiveness of non-pharmacological interventions for patients with dementia: A systematic review and meta-analysis.
    Alzheimer’s Dement. 17: e053962

1. Brain function mapping in Autism Spectrum Disorder

2. Biomarker and assessment tool development for Autism Spectrum Disorder

Atypical pre-attentive and attentive levels of information processing as a symptom-specific biomarker of children with autism spectrum disorder

Y Wang, CTS Siu, H Cheung
P300 as a correlate of false beliefs and false statements
Brain and Behavior, e3021 2023

GQ Zeng, XZ Xiao, Y Wang, CY Tse
Belief in biological origin of race (racial essentialism) increases sensitivities to cultural category changes measured by ERP mismatch negativity (MMN)
Scientific Reports 12 (1), 4400 3 2022

XZ Xiao, Y Wang, GCS Wong, K Zhao, CY Tse
Frontotemporal network in automatic/pre-attentive detection of abstract change: An event-related optical signal (EROS) study
Neuropsychologia 164, 108093 4 2022

TKY Lui, YH Shum, XZ Xiao, Y Wang, ATC Cheung, SSM Chan, Sebastiaan Franciscus Wijnandus Neggers, Chun-Yu Tse
The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study
Brain Stimulation 14 (1), 161-169 9 2021.

CY Tse, YH Shum, XZ Xiao, Y Wang
Fronto-occipital mismatch responses in pre-attentive detection of visual changes: Implication on a generic brain network underlying Mismatch Negativity (MMN)
Neuroimage 244, 118633 9 2021

XZ Xiao, YH Shum, TKY Lui, Y Wang, ATC Cheung, WCW Chu, Sebastiaan FW Neggers, Sandra S‐M Chan, Chun‐Yu Tse
Functional connectivity of the frontotemporal network in preattentive detection of abstract changes: Perturbs and observes with transcranial magnetic stimulation and event -related optical signal
Human brain mapping 41 (11), 2883-2897 9 2020

Y Wang, H Cheung, LTS Yee, CY Tse
Feedback-related negativity (FRN) and theta oscillations: Different feedback signals for non-conform and conform decisions
Biological psychology 153, 107880 23 2020

CY Tse, LY Yip, TKY Lui, XZ Xiao, Y Wang, WCW Chu, NA Parks, Sandra Sau-Man Chan, Sebastiaan Franciscus Wijnandus Neggers
Establishing the functional connectivity of the frontotemporal network in pre-attentive change detection with Transcranial Magnetic Stimulation and event-related optical signal
NeuroImage 179, 403-413 18 2018

Y Wang, C Qu, Q Luo, L Qu, X Li
Like or dislike? Affective preference modulates neural response to others’ gains and losses
PloS one 9 (8), e105694 18 2014.

• Visiting Research Follow at the University College London
• Researcher at the International Brain Lab

• Biological mechanisms underlying neuropsychiatric disorders
• Circuit-based neuropathological states classification
• Cross-species comparison models
• Computation psychiatry
• Digital mental health

2023 The Kavli Foundation NWB Hackathon Award.
2015-2020 Medical Research Council Postdoctoral Training Fellowship, MRC, UK.
2019 FENS IBRO Travel Award, FENS, EU.
2019 Guarantors of Brain Travel Award, Guarantors of Brain, UK.
2019 The Carl Storm Diversity Fellowship, Gordon Research Conference.
2019 Medical Research Council Recognition Award for Public engagement, MRC Harwell Institute, UK.
2018 The 41st Japanese Neuroscience Society Annual Meeting Travel Award, JNS, Japan.
2017 Medical Research Council Special Award Scheme Award, MRC Harwell Institute, MRC, UK.
2017 Travel Award for the 19th Annual Genes, Brain and Behavior Meeting of The International Behavioural and Neural Genetics Society, Madrid, Spain.
2016 Training Grant for mouse genetics course, Wellcome Genome Campus, Hinxton, Cambridge, UK.
2014 Medical Research Council Anatomical Neuropharmacology Unit Travel Award for Inhibitory Control of Brain Plasticity Conference, Poland.
2013 Great Britain-China Educational Trust Scholarship, Great Britain-China Educational Trust, UK.

We study the biological mechanisms behind heritable psychiatric disorders like schizophrenia, bipolar disorder, and autism spectrum disorder (ASD). Our goal is to find new ways to understand, classify, and treat these brain disorders.
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These disorders have strong heritable causes but are characterized as pathologies of the mind. Traditional research methods struggle to study the biological mechanisms behind subjective clinical measures. Our research uses electrical profiles of brain networks to objectively classify perception and cognitive processes. We combine computational models with observations to analyze neuropathological dynamics in humans and mice. Our recent work has established single-cell resolution circuit pathologies in ASD mouse models across multiple brain regions.
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We bridge understanding from genetics, molecular pathways, cellular, metabolic, and immunologic factors with clinical observations using this cross-species approach. By combining high-density biological measurements, causal manipulation, and computational modeling, we aim to develop targeted neuropsychiatric diagnostics and treatments.
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Our current projects address three key questions:

1. How do single-cell dynamics link biological mechanisms to circuit pathology and symptoms? Can brain-wide circuit pathologies improve understanding of perception and identify new treatment?

2. How do external factors like gut microbiomes, sleep abnormalities, and environmental stress influence pathological states and circuit dynamics, and how do these interactions evolve with disease progression and symptoms?

3. Can artificial intelligence be applied to large digital behavioral datasets to improve asymptomatic brain disorder detection and bio-subtyping of neuropsychiatric disorders in the community?

1. Bruijns S. A., International Brain Laboratory, Bougrova K, Laranjeira I.C., Lau P. Y. P., Meijer G. T., Miska N. J., Noel J.-P., Pan- Vazquez A., Roth N., Socha K. Z., Urai A. E., Dayan P.,
   Dissecting the Complexities of Learning With Infinite Hidden Markov Models
   Nature Neuroscience, (2023, accepted).

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2. Findling C., Hubert F., International Brain Laboratory, Acerbi L., Benson B., Benson J., Birman D., Bonacchi N., Carandini M., Catarino J. A., Chapuis G. A., Churchland A. K., Dan Y., DeWitt E.J., Engel T. A., Fabbri M., Faulkner M., Fiete I. R., Freitas- Silva L., Gerçek B., Harris K. D., Häusser M., Hofer S. B., Hu F., Huntenburg J. M., Khanal A., Krasniak C., Langdon C., Latham P. E., Lau P. Y. P., Mainen Z., Meijer G. T., Miska N. J., Mrsic-Flogel T. D., Noel J.-P., Nylund K., Pan-Vazquez A., Paninski L., Pillow J., Rossant C., Roth N., Schaeffer R., Schartner M., Shi Y., Socha K. Z., Steinmetz N. A., Svoboda K., Tessereau C., Urai A. E., Wells M. J., West S. J., Whiteway M. R., Winter O., Witten I. B., Zador A., Dayan P., Pouget A.
   Brain-wide representations of prior information in mouse decision-making
   Nature, (2023, accepted).
   .
3. Bafna A., Lau PYP, Banks G., and Nolan PM,
   Harvesting mouse suprachiasmatic nucleus (SCN) by vibrating microtome for diurnal transcriptome analysis
   STAR Protocol, 2023, accepted. International Brain Laboratory, Banga K., et al. “Reproducibility of in-vivo electrophysiological measurements in mice,” bioRxiv, (2022, doi:10.1101/2022.05.09.491042)..

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4. Banks G, Guillaumin M, Heise I, Lau P, Yin MH, Bourbia N, Aguilar C, Bowl M, Esapa C, Brown L, Hasan S, Tagliatti E, Nicholson E, Bains RS, Wells S, Vyazovskiy VV, Volynski K, Peirson S.
   Aberrant synaptic release underlies sleep/wake transition deficits in a mouse Vamp2 mutant
   Science Advances, 12 Aug 2020, Vol 6, Issue 33, doi:10.1126/sciadv.abb3567.
   .
5. Lamsa K, Lau P.
   Long-term plasticity of hippocampal interneurons during in vivo memory processes
   .
   Curr Opin Neurobiol, 2019 Feb;54:20-27, doi:10.1016/j.conb.2018.08.006.
   .
6. Stewart M, Lau P, Banks G, Bains RS, Castroflorio E, Oliver PL, Dixon CL, Kruer MC, Kullmann DM, Acevedo-Arozena A, Wells SE, Corrochano S, Nolan PM.
   Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities
   Dis Model Mech, 2019 Jan 28, pii: dmm.036806, doi: 10.1242/dmm.036806..

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7. Banks G, Lassi G, Hoerder-Suabedissen A, Tinarelli F, Simon MM, Wilcox A, Lau P, Lawson TN, Johnson S, Rutman A, Sweeting M, Chesham JE, Barnard AR, Horner N, Westerberg H, Smith LB, Molnar Z, Hastings MH, Hirst RA, Tucci V, Nolan PM.
   A missense mutation in Katnal1 underlies behavioral, neurological, and ciliary anomalies
   Mol Psychiatry, 2018 Mar;23(3):713-722, doi: 10.1038/mp.2017.54.

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8. Lau PY, Katona L, Saghy P, Newton K, Somogyi P, Lamsa KP.
   Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo
   Brain Struct Funct, 2017 May;222(4):1809-1827, doi: 10.1007/s00429-016-1309-7.