News

Press Releases on CUHK identifies novel gut microbiome biomarkers to facilitate diagnosis of autism spectrum disorders Pilot clinical study shows modulation of gut microbiome alleviates anxiety symptoms

A research team from The Chinese University of Hong Kong (CUHK)’s Faculty of Medicine (CU Medicine)  has conducted a large cohort study among 1,627 children with and without autism spectrum disorder (ASD) and found alterations in four kingdoms of the gut microbial species including archaea, bacteria, fungi and viruses in children with ASD. Using machine learning, they developed a panel of 31 multikingdom and functional markers that showed high diagnostic performance for ASD and has great potential as a clinical diagnostic tool. The findings were published in Nature Microbiology. In a pilot study, the researchers also showed that modulation of the gut microbiome alleviated symptoms of anxiety in children with ASD, introducing the possibility of a new therapeutic paradigm for the condition

Media Coverage:

1. 研究指自閉症兒童腸道微生態發展較落後 易腸胃不適及影響腦神經運作 (無綫新聞 TVB News)
2. 研究指自閉症兒童腸道微生態發展較遲緩 調節微生物群有助緩解焦慮等 (無綫新聞 TVB News)
3. 中大指調節腸道微生物群　可減輕自閉症患者焦慮等症狀 (有線新聞)
4. 中大團隊發現調節腸道微生態 可減輕自閉症焦慮症狀 (Now新聞台)
5. 香港中文大學醫學院研發嶄新自閉症診斷工具 (鳳凰衛視)
6. 中大研究利用腸道微生物診斷自閉症靈敏度逾九成 (香港電台)
7. 中大研究：腸道微生態與自閉症有密切關聯 (商業電台)
8. Hong Kong researchers create faecal test kit that can detect autism in toddlers (SCMP)
9. 中大醫學院開發腸道微生物診斷自閉症檢測工具 靈敏度達九成 (星島網)
10. 中大研發用糞便樣本診斷自閉症 靈敏度逾九成 改善腸道可舒緩兒童自閉症狀 (Yahoo! 新聞)
11. 中大首創腸道微生物工具診斷自閉症 (大紀元時報)
12. 中大研究:調節腸道微生物群 減自閉症患者焦慮症狀 (信報財經新聞)
13. 中大研究利用腸道微生物診斷自閉症靈敏度逾九成 (巴士的報)
14. 中大研腸道微生態自閉症檢測工具　靈敏度超過9成 (東網)
15. 腸道微生物｜中大發現自閉症與腸道微生物群有關　最快今年底推新型檢測工具 (香港經濟日報Topick)
16. 中大研究以分析腸道微生物檢測自閉症 靈敏度達九成 (輕新聞)
17. 自閉症檢測｜中大研「糞便檢測自閉症」，助及早判斷患自閉症兒童！無創非入侵性、準確度高達九成！(Medical Inspire)
18. 中大研腸道微生物檢測工具 助及早評估兒童患自閉症風險 (am730)
19.  港中大憑藉腸道微生物群評估兒童自閉症 (香港新聞網)
20.  中大醫學院研診斷自閉症檢測工具 靈敏度達九成 改善腸道可減輕症狀 (Oh爸媽)
21.  中大研究發現 腸道微生態與自閉症有關聯 (昭傳媒)
22.  港中大利用肠道微生物开发精准工具诊断自闭症 (科學網)
23. [千禧年代] 中大研究發現腸道微生態與自閉症有密切關聯 (香港電台)
24. 晨早新聞天地(香港電台)
25. [Hong Kong Today] CUHK develops autism test by examining children’s stool (RTHK English)
26.  調節腸道微生物群 助緩解自閉童敏感與焦慮症狀 中大以腸道微生物開發工具診斷自閉症 (成報)
27.  驗糞測自閉風險 最快年底推 中大研發 稱腸道微生態有潛力成治療方案 (明報)
28.  調節腸道微生態 緩解自閉童焦慮 (東方日報)
29. 中大研腸道微生物 測自閉症靈敏度9成 (香港經濟日報)
30. 中大研用腸道微生物診斷自閉症 (大公報)
31. 中大研腸道微生態自閉症檢測工具 (頭條日報)
32.  中大研新技術 驗腸道測自閉 (信報財經新聞)
33. Team creates stool test to detect autism in infants (SCMP)
34. Autism wizzes go with their guts (The Standard)
35. 自閉症檢測｜中大研糞便樣本檢測工具 用腸道微生物標誌物 助及早評估兒童患自閉症風險 (Healthyd.com)

For more details of the study:

University Website:
(English) https://www.cpr.cuhk.edu.hk/en/press/cuhk-identifies-novel-gut-microbiome-biomarkers-to-facilitate-diagnosis-of-autism-spectrum-disorders-pilot-clinical-study-shows-modulation-of-gut-microbiome-alleviates-anxiety-symptoms/
(Chinese) https://www.cpr.cuhk.edu.hk/tc/press/cuhk-identifies-novel-gut-microbiome-biomarkers-to-facilitate-diagnosis-of-autism-spectrum-disorders-pilot-clinical-study-shows-modulation-of-gut-microbiome-alleviates-anxiety-symptoms/

CU Medicine Website:
(English) https://www.med.cuhk.edu.hk/press-releases/cuhk-identifies-novel-gut-microbiome-biomarkers-to-facilitate-diagnosis-of-autism-spectrum-disorders-pilot-clinical-study-shows-modulation-of-gut-microbiome-alleviates-anxiety-symptoms
(Chinese) https://www.med.cuhk.edu.hk/tc/press-releases/cuhk-identifies-novel-gut-microbiome-biomarkers-to-facilitate-diagnosis-of-autism-spectrum-disorders-pilot-clinical-study-shows-modulation-of-gut-microbiome-alleviates-anxiety-symptoms

Social media posts:
FB: https://www.facebook.com/share/p/fzBag7zSUuU989cC/
LinkedIn: https://www.linkedin.com/feed/update/urn:li:activity:7217113160653160450
X: https://x.com/CUHKMedicine/status/1811348026797224404
Threads: https://www.threads.net/@cuhkmedicine/post/C9R4FPvBwYa
Weibo: https://weibo.com/7768463285/On5jH0BcG

Press conference on CU Medicine-developed app proves effective in assessing depression

Depression is the leading health-related burden globally, affecting an estimated 300 million people. In Hong Kong, the prevalence of depression was about 8.3% according to the 2015 Hong Kong Mental Morbidity Survey. The current gold standard for the diagnosis of depression relies on clinical evaluation, but mental health services are insufficient to meet the demand in a lot of regions, including Hong Kong. The Chinese University of Hong Kong’s (CUHK) Faculty of Medicine (CU Medicine) has developed a mobile depression assessment app that deploys multimodal artificial intelligence (AI) analysis, which means using AI to analyse the user’s multimodal data, including facial expressions, voice, language and subjective mood state, as well as rest-activity statistics, measured using actigraphy. CUHK researchers proved the new technology is effective in diagnosing depression. The findings were recently published in Translational Psychiatry.

Media Coverage:

1.中大醫學院研發手機應用程式 透過 AI評估抑鬱症 (有線新聞 )
2.中大研發手機 APP以 AI評估使用者患抑鬱風險 準確率可達八成 (無綫新聞 )
3.香港中大医学院研发手机程式有效评估抑郁症 |快报 (鳳凰衛視 )
4.中大醫學院研發出有效評估抑鬱症程式 冀人工智能輔助臨床診斷 （香港電台）
5.CUHK showcases mobile app to diagnose depression (RTHK English)
6.Chinese University of Hong Kong researchers develop AI-powered app to diagnose depression (SCMP)
7.中大 AI App 可測曾否患抑鬱 (明報 新聞網）
8.中大研發手機應用程式 AI評估抑鬱症 （東網)
9.中大醫學院研發出有效評估抑鬱症程式 冀 AI輔助臨床診斷 (am730)
10.中大醫學院研發手機程式有效評估抑鬱症 (信報財經新聞)
11.中大醫學院研發評估抑鬱症的手機程式 準確度達 81% 本地 (商業電台）
12.中大研發應用程式評估抑鬱症 （新城電台)
13.中大研發 app評估抑鬱症 助舒緩醫護人員壓力 (大 紀元時報 )
14.約 60萬港人深受抑鬱折磨 中大醫學院研發手機程式腕動計有效評估(附抑鬱症四項特徵) （星島頭條網)
15.中大研發手機 APP評估抑鬱症 利用人工智能輔助臨床診斷 (巴士的報 )
16.香港中大医学院研发手机程式有效评估抑郁症 (163.com)
17.Innovative App Developed at CUHK Predicts Depression Using AI (Smartphone Magazine)
18.Innovative App to Monitor Depression Unveiled by CUHK Medical Faculty (ElBlog.lp)
19.A.I.-POWERED app can measure if user is depressed (SCMP)
20.透過人工智能分析診斷 中大醫學院研發手機程式有效評估抑鬱症 (成報 )
21.中大研發 App AI觀貌辨聲評估抑鬱症 (文匯報 )
22.中大研發 App篩查抑鬱症 （信報財經新聞)
23.中大研發 AI 評估抑鬱症手機 App 拆解患者 5 個生物特徵 (eZone)
24.港中大研發手機 App助評估抑鬱症 （中通社)
25.中大醫學院研發的手機程式有效評估抑鬱症 （香港 商報 網）
26. 中大研發AI APP 可測曾否患抑鬱症 (自由風自由Phone 10 June 2024))
27.  Newly developed mental health app (Backchat 11 June 2024)
28. 中大醫學院研發出評估抑鬱症手機程式 冀助及早診斷並介入治療 (千禧年代 11 June 2024)
29. 你有無抑鬱症 ? 手機影樣即知 – 中大醫學院研發 (uwire.hk 2 July 2024)
30. 診斷抑鬱，用App都得 (RTHK32 凝聚香港 25 June 2024)
31. AI應用｜7成精神障礙患者未尋求支援！中大醫學院研手機程式有效評估抑鬱症 (Yahoo News 13 June 2024)
32. This app can predict moods (The Standard Education 25 June 2024)

For more details of the study:

University Website:
(English) https://www.cpr.cuhk.edu.hk/en/press/cu-medicine-developed-app-proves-effective-in-assessing-depression/
(Chinese) https://www.cpr.cuhk.edu.hk/tc/press/cu-medicine-developed-app-proves-effective-in-assessing-depression/

Faculty Website:
(English) https://www.med.cuhk.edu.hk/press-releases/cu-medicine-developed-app-proves-effective-in-assessing-depression
(Chinese) https://www.med.cuhk.edu.hk/tc/press-releases/cu-medicine-developed-app-proves-effective-in-assessing-depression

Social media posts:
Facebook: https://www.facebook.com/share/p/ZP8Gm35H4Vb8EpG4/
Linkedin: https://www.linkedin.com/feed/update/urn:li:activity:7205402048035524609
Twitter: https://x.com/CUHKMedicine/status/1799634995600056556
Threads: https://www.threads.net/@cuhkmedicine/post/C7-r9u-hX0l/?xmt=AQGzpZiAkTnDasz9KkFwqhYLZ_lt3ZvY-X_yuH3RUE9Ntw
Weibo: https://weibo.com/7768463285/5043315425150613

Press conference on CU Medicine study reveals increasing cognitive activity participation strengthens brain network

Cognitive activities are often recommended to older adults for cognitive maintenance. However, biological evidence supporting this has been scarce. A pioneering cross-disciplinary study by The Chinese University of Hong Kong’s (CUHK) Faculty of Medicine (CU Medicine) has revealed that increasing cognitive activity participation can have positive neuromodulatory effects in older adults. The researchers call for greater participation in cognitive activities as a lifestyle intervention to prevent dementia. The findings were published in the international peer-reviewed journal eBioMedicine, part of The Lancet.

Press conference on CUHK launches the Jockey Club Sleep Well Project – Hong Kong’s first large-scale community outreach programme to promote sleep health, using cognitive behavioural therapy to treat insomnia

1.港人三成失眠困擾 樂眠計劃擬助萬人入夢 (明報)
2.中大推樂眠無憂計劃 非藥物治失眠 (am730)
3.中大計劃為失眠者提供睡眠指導 (星島日報)
4.馬會夥中大推治失眠計劃 (信報財經新聞)
5.BackChat (RTHK English)
6.中大推全港首個大型睡眠健康推廣計劃 (香港電台晨早新聞天地)
7.Thousands offered help for sleep disorders (RTHK Hong Kong Today)
8.News at Eleven (RTHK English)
9. 中大及賽馬會推計劃提供睡眠評估及指導 目標三年半內服務一萬人 (香港經濟日報網topick)
10.港中大推出香港首個大型睡眠健康社區推廣計劃 (香港新聞網)
11.CUHK rolls out scheme to tackle insomnia (RTHK English)
12.中大推出全港首個社區計劃 三年半內為一萬人提供睡眠指導服務 (香港電台)
13.中大推樂眠計劃 協助萬名睡眠障礙患者 (大紀元時報)
14.中大推出全港首個大型睡眠健康社區計劃 3年半內為1萬人提供睡眠指導 (am730即時新聞)
15.中大指四成受訪港人平日睡眠少於7小時 三成受中度或以上失眠困擾 醫學院為失眠者配對「睡眠教練」(明報即時新聞)
16.逾40%受訪港人受失眠困擾 團體首推樂眠計劃助萬人尋夢 (東方日報即時)
17.中大推出全港首個社區計劃 三年半內為一萬人提供睡眠指導服務 (香港電台)
18.中大醫學院夥5機構推「賽馬會樂眠無憂計劃」 為一萬名參加者提供睡眠指導 (星島頭條網)
19.中大推出全港首個睡眠健康社區計劃 目標3年半內為一萬人指導睡眠 (巴士的報)

Media Attendance

Faculty Website:
(English) https://www.med.cuhk.edu.hk/press-releases/cuhk-launches-the-jockey-club-sleep-well-project
(Chinese) https://www.med.cuhk.edu.hk/tc/press-releases/cuhk-launches-the-jockey-club-sleep-well-project

University Website:
(English) https://www.cpr.cuhk.edu.hk/en/press/cuhk-launches-the-jockey-club-sleep-well-project-hong-kongs-first-large-scale-community-outreach-programme-to-promote-sleep-health-using-cognitive-behavioural-therapy-to-treat-ins/
(Chinese) https://www.cpr.cuhk.edu.hk/tc/press/cuhk-launches-the-jockey-club-sleep-well-project-hong-kongs-first-large-scale-community-outreach-programme-to-promote-sleep-health-using-cognitive-behavioural-therapy-to-treat-ins/

Faculty’s social media platforms:
• Facebook: https://www.facebook.com/100070125563861/posts/pfbid0qpGSgiH4eCpCeNFvvaXUgLSGqL42KciCMvFoG72JtxcL22thi788ZVgSfQ7G4NMPl/
• LinkedIn: https://www.linkedin.com/feed/update/urn:li:activity:7174014605923377152
• Twitter/X: https://twitter.com/CUHKMedicine/status/1768249261660229764
• Threads: https://www.threads.net/@cuhkmedicine/post/C4fo5RBBlnp/?igshid=MzRlODBiNWFlZA==
Weibo: https://weibo.com/7768463285/O509NsNjc

Warm congratulations to Professor Wing Yun-kwok, Faculty of Medicine on being appointed as Choh-Ming Li Professor of Psychiatry in the Inauguration Ceremony of the Choh-Ming Li and Wei Lun Professorships and Presentation of Teaching and Research Awards 2024 held on 6 March 2024.

PRESS RELEASES

Media reports:

1. 兩成半學童受一種以上精神疾病困擾 專家倡學校放輕學習進度 (am730)
2. 1/4 學童有精神疾病 7%想死曾試 「自殺屬冰山尖端」 諮委會促解下層問題 (明報)
3. 助三層識別機制發揮 黃仁龍倡照顧教師精神健康 (明報)
4. 長者調查 四成認障照顧者 壓力中等至嚴重 (明報)
5. 兩成半童受精神病困擾 4%曾萌死念 (香港經濟日報)
6. 兩成半受訪學童 精神健康響警鐘 近 4%指過去一年曾萌死念 (東方日報)
7. 調查揭每 4 人就有 1 患者 精神病困擾兒童青少年 (頭條日報)
8. 25% of city’s children suffer from mental disorder (South China Morning Post)
9. 財知大道 (新城財經台)
10. 調查指近兩成半兒童及青少年受精神疾病困擾 (自由風自由 Phone)
11. 晨旱新聞天地 (香港電台)
12. Parents urged to seek mental health support for kids (RTHK English)
13. Rate of suicidal thoughts among highschool pupils ‘alarming’ (RTHK English HK Today)
14. Backchat (RTHK English)
15. 調查揭每 4 名受訪兒童及青少年有 1 人受精神疾病困擾 7%有輕生想法 (HK01)
16. 精神健康｜8.4%受訪中學生有輕生念 「對立性反抗症」成第二普遍學童精神疾病 (集誌社)
17. 調查指近兩成半受訪兒童及青少年受至少一種精神疾病困擾 (香港電台)
18. 中大指學童輕生屬冰山尖端應預防 黄仁龍籲反思一試定生死想法 (香港電台視像新聞)
19. ‘Kids with mental health issues need outside help’ (RTHK English)
20. 四分一受訪兒童青少年抑鬱等 近 4%過去一年欲輕生 (東方日報即時新聞)
21. 調查指近兩成半受訪兒童及青少年受至少一種精神疾病困擾 (文匯網)
22. 中大調查｜兩成長者有認知障礙 4%青幼年曾輕生 (信報網)
23. 調查指近兩成半兒童及青少年受精神疾病困擾 多為焦慮及抑鬱症 (點新聞)
24. 調查指香港兩成半兒童及青少年受精神病困擾 (香港新聞網)
25. 中大醫學院調查: 8.4%中學生曾有自殺想法 (低聲道)
26. 中大醫學院：每 4 名兒童及青少年有 1 人患精神病 常見過度活躍症焦慮症等 (巴士的報)
27. 【精神健康】中大研究指 4%學童曾有自殺念頭 黄仁龍籲學校將學童精神健康放首位 (香
港經濟日報網)
28. 22%受訪長者有輕度認知障礙 四成照顧者壓力中等至嚴重 中大促提供個人化社區服務
(明報網)
29. 四分一受訪學童過去一年內出現精神疾病 學者指精神、學業及家庭壓力千絲萬縷促正視
(明報網)
30. 調查：24%兒童及青少年過去 1 年受精神疾病困擾 近半數照顧者不願尋求專業協助
(am730 網)

University Website: 

(English) https://www.cpr.cuhk.edu.hk/en/press/cuhk–announces–survey–results–on–the–mental–healthof–local–child–adolescent–and–elderly–populations/

(Chinese) https://www.cpr.cuhk.edu.hk/tc/press/cuhk–announces–survey–results–on–the–mental–healthof–local–child–adolescent–and–elderly–populations/

Faculty Website:

(English) https://www.med.cuhk.edu.hk/press–releases/cuhk–announces–survey–results–on–the–mentalhealth–of–local–child–adolescent–and–elderly–populations

(Chinese) https://www.med.cuhk.edu.hk/tc/press–releases/cuhk–announces–survey–results–on–themental–health–of–local–child–adolescent–and–elderly–populations

Faculty’s social media platforms:

• Facebook:

https://www.facebook.com/photo/?fbid=664885689192277&set=a.557262156621298

• Twitter: https://twitter.com/CUHKMedicine/status/1729811172654813441
• Threads: https://www.threads.net/@cuhkmedicine/post/C0OhXvNJA36
• LinkedIn: https://www.linkedin.com/feed/update/urn:li:share:7135576556130758658/
• Weibo: https://weibo.com/7768463285/NuPCIaA2j

We are delighted to announce that Professor WING Yun Kwok, our Department Chairman, has been appointed as the Choh-Ming Li Professor of Psychiatry (卓敏精神科學教授) by the Vice-Chancellor and President.

This appointment, in recognition of his exceptional academic accomplishments, is effective from August 1, 2023, and is valid for a term of 5 years.

CUHK confirms depression sufferers with rapid eye movement sleep behaviour disorder harbour familial predisposition to neurodegeneration Provides new insights on improving precision psychiatry and preventing neurodegeneration

1. [Hong Kong Today] Sleep disorders indicate higher dementia risk (RTHK English)
2. 中大研究 精神障礙+發夢期夢遊屬腦退化先兆 (am730)
3. 中大研究：重度抑鬱夢遊患者 直系親屬腦退化風險高4倍 (明報)
4. 同患抑鬱發夢期夢遊 親屬腦退化風險高4倍 (東方日報)
5. 患抑鬱兼發夢期夢遊 直系親屬易腦退化 中大：有望提前15年發現治療 (晴報)
6. News at 7:30 (TVB Pearl)
7. Risk of sleep disorder linked to neurodegeneration increases in those with family history of condition: Hong Kong study (SCMP)
8. 研究指若同時患重度抑鬱及夢遊 其直系親屬患腦退化風險較高 (無線新聞)
9. 中大研究：重度抑鬱及發夢期夢遊患者直系親屬較大機會患腦退化 (無線新聞)
10. 重度抑鬱患者如患發夢期夢遊 直系親屬腦退化風險較高 (Now 新聞台)
11. 中大證實抑鬱症夢遊共病患者家族易腦退化 (新城電台)
12. 中大研究揭有夢遊重度抑鬱症病人　直系親屬患腦退化症風險高4倍 (香港01)
13. CUHK links sleep disorder to neurodegenerative disease (RTHK English)

Press Conference news for CUHK discovers the occurrence of gut microbiome dysbiosis at the prodromal stages of Parkinson’s disease, Gives novel insights into neurodegenerative prevention, intervention and diagnosis

Now TV
時事全方位:腸道健康與柏金遜病關係(一)
時事全方位:腸道健康與柏金遜病關係(二)

香港電台
中大研究指腸道微生態失衡為柏金遜病非常早期風險因素

新城電台
中大研究:腸道微生態可找出柏金遜病風險

東方日報即時新聞
長期便秘成柏金遜病早期風險因素　中大指益生菌可及早干預

巴士的報
中大研究：腸道微生態失衡 是柏金遜病早期風險因素

明報
中大研究：腸道菌失衡 柏金遜遠因 患者確診廿年前已有便秘 團隊指益生菌有望預防

成報
中大發現 腸道微生態失衡為柏金遜症元兇 將來有望可預防

頭條日報
腸道微生態失衡 早於「發夢期夢遊」出現 中大研長期便秘或為柏金遜徵兆

成報
柏金遜病早期風險因素 中大揭包括腸道微生態失衡

東方日報
發夢期夢遊 柏金遜病先兆

晴報
中大研究︰腸道微生態失衡 為柏金遜非常早期風險因素

香港電台
晨早新聞天地
(from 49:08 to 54:20)

新城電台
財知大道
(from 06:55 to 15:45)

South China Morning Post
Hong Kong researchers find links between onset of Parkinson’s and gut microbiome imbalance, marking first step in developing treatments

香港新聞網
港中大發現腸道微生態失衡是柏金遜早期風險因素

中國新聞網
港中大研究指腸道微生態失衡為帕金森病早期風險因素

Urbanlife Health
腦退化成因】中大研究發現柏金遜病先兆為「發夢期夢遊」及便秘 有望透過腸道微生態預防腦退化疾病

The role of sleep and dreams in long-COVID.
Scarpelli S, De Santis A, Alfonsi V, Gorgoni M, Morin CM, Espie C, Merikanto I, Chung F, Penzel T, Bjorvatn B, Dauvilliers Y, Holzinger B, Wing YK, Partinen M, Plazzi G, De Gennaro L.
J Sleep Res. 2023 Jun;32(3):e13789. doi: 10.1111/jsr.13789. Epub 2022 Nov 18.
PMID: 36398720

Secular trends of sleep-wake patterns in Hong Kong preschoolers.
Lan QY, Chan KC, Au CT, Chan PH, Chan NY, Wing YK, Li AM, Lam HS.
Sleep Med. 2023 Apr;104:73-82. doi: 10.1016/j.sleep.2023.02.018. Epub 2023 Feb 27.
PMID: 36898189

Advanced Diffusion MRI for prediction of Stroke Recovery.
Hui ES.
J Magn Reson Imaging. 2023 May;57(5):1312-1319. doi: 10.1002/jmri.28523. Epub 2022 Nov 15.
PMID: 36378071

Meaning in Life and Depression in Low-Income Families in Hong Kong during the COVID-19 Pandemic.
Chen EM, Chan BKK, Lee ATC.
East Asian Arch Psychiatry. 2023 Mar;33(1):15-20. doi: 10.12809/eaap2244.
PMID: 36991551

Association of accelerometer-derived circadian abnormalities and genetic risk with incidence of atrial fibrillation.
Yang L, Feng H, Ai S, Liu Y, Lei B, Chen J, Tan X, Benedict C, Wang N, Wing YK, Qi L, Zhang J.
NPJ Digit Med. 2023 Mar 4;6(1):31. doi: 10.1038/s41746-023-00781-3.
PMID: 36869222

A comparison of sleep-wake patterns among school-age children and adolescents in Hong Kong before and during the COVID-19 pandemic.
Chau SWH, Hussain S, Chan SSM, Wong OWH, Zhang J, Feng H, Lai KYC, Ling S, So SHW, Tsoi KKF, Wing YK, Hung SF, Leung PWL.
J Clin Sleep Med. 2023 Apr 1;19(4):749-757. doi: 10.5664/jcsm.10422.
PMID: 36692167

Association between hypersomnolence and the COVID-19 pandemic: The International COVID-19 Sleep Study (ICOSS).
Sarkanen T, Partinen M, Bjorvatn B, Merikanto I, Benedict C, Nadorff MR, Bolstad CJ, Espie C, Matsui K, Chung F, Morin CM, Wing YK, Penzel T, Macêdo T, Mota-Rolim S, Holzinger B, Plazzi G, De Gennaro L, Landtblom AM, Inoue Y, Sieminski M, Leger D, Dauvilliers Y.
Sleep Med. 2023 Jul;107:108-115. doi: 10.1016/j.sleep.2023.04.024. Epub 2023 May 6.
PMID: 37156053

Sleep and academic performance among students in Hong Kong: Curvilinear relationship suggesting an optimal amount of sleep.
Chan NY, Wu WJ, Chan JWY, Chan KCC, Li AM, Chan SSM, Hau KT, Wing YK.
Sleep Med. 2023 Jun;106:97-105. doi: 10.1016/j.sleep.2023.04.001. Epub 2023 Apr 6.
PMID: 37079951

Validation of the Revised Illness Perception Questionnaire of Obstructive Sleep Apnea among Elderly Chinese in the General Population.
Yu Y, Wu AMS, Wing YK, Chan JWY, Lau MMC, Lau JTF.
Sleep Breath. 2023 Mar;27(1):337-344. doi: 10.1007/s11325-022-02598-y. Epub 2022 Apr 4.
PMID: 35377089

Evaluating the efficacy and safety of transcranial pulse stimulation on adolescents with attention deficit hyperactivity disorder: Study protocol of a pilot randomized, double-blind, sham-controlled trial.
Cheung T, Chau B, Fong KH, Lam JYT, Lo H, Li MH, Li AMMC, Beisteiner R, Lei S, Yee BK, Cheng CPW.
Front Neurol. 2023 Mar 28;14:1076086. doi: 10.3389/fneur.2023.1076086. eCollection 2023.
PMID: 37056363

Association between the mood stabilizing treatment of bipolar disorder and risk of suicide attempts: A self-controlled case series study.
Ng VWS, Leung MTY, Chan EW, Lee EHM, Hayes JF, Osborn DPJ, Wing YK, Lau WCY, Man KKC, Wong ICK.
Psychiatry Res. 2023 Jul;325:115236. doi: 10.1016/j.psychres.2023.115236. Epub 2023 May 7.
PMID: 37172400

Treatment-resistant depression and risk of autoimmune diseases: evidence from a population-based cohort and nested case-control study.
Chan VKY, Luo H, Chan SSM, Lau CS, Yeung WWY, Peng K, Tong X, Lam MPS, Wong ICK, Li X.
Transl Psychiatry. 2023 Mar 3;13(1):76. doi: 10.1038/s41398-023-02383-9.
PMID: 36864045

Tissue clearing to examine glioma complexity in 3 dimensions.
Yang X, Ye Z, Zhang M, Ouyang Y, He D, Wang X, Lai HM, Sun H.
J Neuropathol Exp Neurol. 2023 Apr 20;82(5):376-389. doi: 10.1093/jnen/nlad024.
PMID: 37023472 Review.

Joint association of physical activity and sleep duration with risk of all-cause and cause-specific mortality: a population-based cohort study using accelerometry.
Liang YY, Feng H, Chen Y, Jin X, Xue H, Zhou M, Ma H, Ai S, Wing YK, Geng Q, Zhang J.
Eur J Prev Cardiol. 2023 Mar 29:zwad060. doi: 10.1093/eurjpc/zwad060. Online ahead of print.
PMID: 36990109

Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study.
Jin X, Chen Y, Feng H, Zhou M, Chan JWY, Liu Y, Kong APS, Tan X, Wing YK, Liang YY, Zhang J.
J Sport Health Sci. 2023 Mar 3:S2095-2546(23)00021-2. doi: 10.1016/j.jshs.2023.03.001. Online ahead of print.
PMID: 36871624

Changed epidemiology of narcolepsy before, during, and after the 2009 H1N1 pandemic: a nationwide narcolepsy surveillance network study in mainland China, 1990-2017.
Wang X, Xiao F, Wang Y, Deng X, Chen Z, Dong X, Wang W, Li C, Xu Z, Wu H, Yu H, Su C, Wang Z, Tang X, Lv Y, Li Y, Sun S, Huang J, Hao L, Wei X, Deng L, Huang YS, Zhang J, Wing YK, Zhang J, Mignot E, Han F, Yu H.
Sleep. 2023 Mar 9;46(3):zsac325. doi: 10.1093/sleep/zsac325.
PMID: 36595587

Association between accelerometer-measured amplitude of rest-activity rhythm and future health risk: a prospective cohort study of the UK Biobank.
Feng H, Yang L, Ai S, Liu Y, Zhang W, Lei B, Chen J, Liu Y, Chan JWY, Chan NY, Tan X, Wang N, Benedict C, Jia F, Wing YK, Zhang J.
Lancet Healthy Longev. 2023 May;4(5):e200-e210. doi: 10.1016/S2666-7568(23)00056-9.
PMID: 37148892

Joint Associations of Device-measured Sleep Duration and Efficiency with All-cause and Cause-specific Mortality: A Prospective Cohort Study of 90 398 UK Biobank Participants.
Liang YY, Ai S, Xue H, Chen Y, Zhou J, Shu X, Weng F, Zhou M, Ma H, Zhang J, Geng Q, Wing YK.
J Gerontol A Biol Sci Med Sci. 2023 Apr 26:glad108. doi: 10.1093/gerona/glad108. Online ahead of print.
PMID: 37186145

Early- and late-onset of isolated rapid eye movement sleep behavior disorder: A retrospective cohort study.
Zhou L, Huang B, Wang J, Chau SW, Chan JW, Zhang J, Yu MW, Tsang JC, Li SX, Mok VC, Wing YK, Liu Y.
Sleep Med. 2023 May;105:1-8. doi: 10.1016/j.sleep.2023.03.007. Epub 2023 Mar 7.
PMID: 36934616

The impacts of intra-individual daily sleep variability on daytime functioning and sleep architecture in healthy young adults: An experimental study.
Sun W, Cheung FTW, Chan NY, Zhang J, Chan JWY, Chan KCC, Wing YK, Li SX.
J Sleep Res. 2023 Jun 27. doi: 10.1111/jsr.13967. Online ahead of print.
PMID: 37366548

Epidemiology, Symptomatology, and Risk Factors for Long COVID Symptoms: Population-Based, Multicenter Study.
Wong MC, Huang J, Wong YY, Wong GL, Yip TC, Chan RN, Chau SW, Ng SC, Wing YK, Chan FK.
JMIR Public Health Surveill. 2023 Mar 7;9:e42315. doi: 10.2196/42315.
PMID: 36645453

High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration.
Kwok AJ, Lu J, Huang J, Ip BY, Mok VCT, Lai HM, Ko H.
Semin Cell Dev Biol. 2023 Jun 26:S1084-9521(23)00131-3. doi: 10.1016/j.semcdb.2023.06.005. Online ahead of print.
PMID: 37380595

Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.
Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y.
J Sleep Res. 2023 Jun;32(3):e13791. doi: 10.1111/jsr.13791. Epub 2022 Nov 21.
PMID: 36410741

Predictors of dropout in university students participating in an 8-week e-mail-based cognitive-behavioral therapy for insomnia intervention.
Nam H, Chang J, Trockel M, Okajima I, Yang CM, Chan NY, Li S, Suh S.
Sleep Breath. 2023 Mar;27(1):345-353. doi: 10.1007/s11325-022-02609-y. Epub 2022 Apr 12.
PMID: 35412222

The association of nocturnal enuresis with autonomic dysfunctions, mood disturbances and sleepwalking in isolated rapid eye movement sleep behavior disorder.
Lin Y, Huang B, Zhou L, Wang J, Shi T, Chau SWH, Chan JWY, Liu Y, Wing YK.
Sleep. 2023 Mar 9:zsad062. doi: 10.1093/sleep/zsad062. Online ahead of print.
PMID: 36892212

Association of circadian rest-activity rhythms with cardiovascular disease and mortality in type 2 diabetes.
Yang L, Feng H, Chen J, Kwok Wing Y, Benedict C, Tan X, Zhang J.
Diabetes Res Clin Pract. 2023 Mar;197:110262. doi: 10.1016/j.diabres.2023.110262. Epub 2023 Jan 20.
PMID: 36690211

Effect of surgical intervention for childhood OSA on blood pressure: A randomized controlled study.
Au CT, Chan KC, Lee DLY, Leung NMW, Chow SMW, Kwok KL, Wing YK, Li AM.
Sleep Med. 2023 Jul;107:9-17. doi: 10.1016/j.sleep.2023.04.006. Epub 2023 Apr 11.
PMID: 37094489

Diversity in verbal fluency performance and its associations with MRI-informed brain age matrices in normal ageing and neurocognitive disorders.
Lu H, Li J, Fung AWT, Lam LCW.
CNS Neurosci Ther. 2023 Mar 13. doi: 10.1111/cns.14144. Online ahead of print.
PMID: 36914578

Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives.
Huang B, Chau SWH, Liu Y, Chan JWY, Wang J, Ma SL, Zhang J, Chan PKS, Yeoh YK, Chen Z, Zhou L, Wong SH, Mok VCT, To KF, Lai HM, Ng S, Trenkwalder C, Chan FKL, Wing YK.
Nat Commun. 2023 May 2;14(1):2501. doi: 10.1038/s41467-023-38248-4.
PMID: 37130861

Effectiveness of one-week internet-delivered cognitive behavioral therapy for insomnia to prevent progression from acute to chronic insomnia: A two-arm, multi-center, randomized controlled trial.
Yang L, Zhang J, Luo X, Yang Y, Zhao Y, Feng F, Liu S, Zhang C, Li Z, Wang C, Wang W, Jiang F, Zhang Y, Hu Y, Su C, Wu H, Yu H, Li SX, Wing YK, Luo Y, Zhang B.
Psychiatry Res. 2023 Mar;321:115066. doi: 10.1016/j.psychres.2023.115066. Epub 2023 Jan 26.
PMID: 36716552

Familial α-synucleinopathy spectrum features in patients with psychiatric REM sleep behaviour disorder.
Wang J, Lam SP, Huang B, Liu Y, Zhang J, Yu MWM, Tsang JCC, Zhou L, Chau SWH, Chan NY, Chan JWY, Schenck CH, Li SX, Mok VCT, Ma KKY, Chan AYY, Wing YK.
J Neurol Neurosurg Psychiatry. 2023 Jun 30:jnnp-2022-330922. doi: 10.1136/jnnp-2022-330922. Online ahead of print.
PMID: 37399287

Association between matched chronotype and poor mental health among shift workers: a systematic review and meta-analysis.
Li B, Liao G, Lee PMY, Huss A, Ma YTJ, Chan JW, Wing YK, Tse LA.
J Epidemiol Community Health. 2023 May 31:jech-2022-220280. doi: 10.1136/jech-2022-220280. Online ahead of print.
PMID: 37258217

Bright Light Therapy for Cancer-related Fatigue in a Palliative Care Unit: A Feasibility Study.
Tang JH, Wing YK, Chan JWY, Lo RSK.
J Pain Symptom Manage. 2023 Mar;65(3):e237-e240. doi: 10.1016/j.jpainsymman.2022.10.008. Epub 2022 Oct 27.
PMID: 36441072

Isolated rapid eye movement sleep behaviour disorder: clinical and research implications.
Stefani A, Trenkwalder C, Arnulf I, Bliwise DL, Boeve BF, Inoue Y, Iranzo A, Lewis SJ, Provini F, Schenck C, Wenning GK, Wing YK, Hogl B, Videnovic A.
J Neurol Neurosurg Psychiatry. 2023 Jul;94(7):581-582. doi: 10.1136/jnnp-2022-330913. Epub 2023 Mar 28.
PMID: 36977554

Breast cancer risks following antipsychotic use in women with bipolar disorder versus schizophrenia: A territory-wide nested case-control study spanning two decades.
Chu RYK, Wei Y, Osborn DP, Ng VWS, Cheng FWT, Chan SKW, Chan SSM, Wong ICK, Chan EWY, Lai FTT.
Psychiatry Res. 2023 Jun 7;326:115287. doi: 10.1016/j.psychres.2023.115287. Online ahead of print.
PMID: 37320990

Author Correction: An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish.
Sy SKH, Chan DCW, Chan RCH, Lyu J, Li Z, Wong KKY, Choi CHJ, Mok VCT, Lai HM, Randlett O, Hu Y, Ko H.
Nat Commun. 2023 May 5;14(1):2599. doi: 10.1038/s41467-023-38152-x.
PMID: 37147316

Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study.
Feng H, Yang L, Liang YY, Ai S, Liu Y, Liu Y, Jin X, Lei B, Wang J, Zheng N, Chen X, Chan JWY, Sum RKW, Chan NY, Tan X, Benedict C, Wing YK, Zhang J.
Nat Commun. 2023 Feb 18;14(1):930. doi: 10.1038/s41467-023-36546-5.
PMID: 36805455

Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses.
Liang YY, Chen J, Peng M, Zhou J, Chen X, Tan X, Wang N, Ma H, Guo L, Zhang J, Wing YK, Geng Q, Ai S.
J Transl Med. 2023 Feb 7;21(1):90. doi: 10.1186/s12967-023-03920-2.
PMID: 36747249

Circadian disruption and sleep disorders in neurodegeneration.
Shen Y, Lv QK, Xie WY, Gong SY, Zhuang S, Liu JY, Mao CJ, Liu CF.
Transl Neurodegener. 2023 Feb 13;12(1):8. doi: 10.1186/s40035-023-00340-6.
PMID: 36782262

Impact of COVID-19 on the sleep-wake patterns of preschool children.
Wong OY, Au CT, Yuen HM, Yu KN, Lan QY, Chan NY, Tsang CC, Li AM, Chan KC.
Sleep Med. 2023 Jan;101:50-57. doi: 10.1016/j.sleep.2022.10.012. Epub 2022 Oct 23.
PMID: 36334501

Evaluation of a group-based sensorimotor intervention programme to improve Chinese handwriting of primary school students.
Li-Tsang CWP, Li TMH, Yang CN, Cheung PPP, Au KY, Chan YP, Cheung KY, Ho KH, Kwok KW, Leung HWH.
Heliyon. 2022 Dec 23;9(2):e12554. doi: 10.1016/j.heliyon.2022.e12554. eCollection 2023 Feb.
PMID: 36816238

Biomarkers for prognostic functional recovery poststroke: A narrative review.
Zhang JJ, Sánchez Vidaña DI, Chan JN, Hui ESK, Lau KK, Wang X, Lau BWM, Fong KNK.
Front Cell Dev Biol. 2023 Jan 9;10:1062807. doi: 10.3389/fcell.2022.1062807. eCollection 2022.
PMID: 36699006

Ageism, dementia, and culture.
Zhong BL, Chiu HF.
Int Psychogeriatr. 2023 Jan;35(1):1-2. doi: 10.1017/S1041610223000029.
PMID: 36748652 No abstract available.

Secular trends of sleep-wake patterns in Hong Kong preschoolers.
Lan QY, Chan KC, Au CT, Chan PH, Chan NY, Wing YK, Li AM, Lam HS.
Sleep Med. 2023 Apr;104:73-82. doi: 10.1016/j.sleep.2023.02.018. Epub 2023 Feb 27.
PMID: 36898189

Meaning in Life and Depression in Low-Income Families in Hong Kong during the COVID-19 Pandemic.
Chen EM, Chan BKK, Lee ATC.
East Asian Arch Psychiatry. 2023 Mar;33(1):15-20. doi: 10.12809/eaap2244.
PMID: 36991551

A forgotten sign of depression – the omega sign and its implication.
Chen J, Li CT, Li TMH, Chan NY, Chan JWY, Liu Y, Lee TMC, Wing YK.
Asian J Psychiatr. 2023 Feb;80:103345. doi: 10.1016/j.ajp.2022.103345. Epub 2022 Nov 21.
PMID: 36423435 No abstract available.

The Effectiveness of Electrical Vestibular Stimulation (VeNS) on Symptoms of Anxiety: Study Protocol of a Randomized, Double-Blinded, Sham-Controlled Trial.
Cheung T, Lam JYT, Fong KH, Ho YS, Ho A, Cheng CP, Sittlington J, Xiang YT, Li TMH.
Int J Environ Res Public Health. 2023 Feb 27;20(5):4218. doi: 10.3390/ijerph20054218.
PMID: 36901227

Validation of the Revised Illness Perception Questionnaire of Obstructive Sleep Apnea among Elderly Chinese in the General Population.
Yu Y, Wu AMS, Wing YK, Chan JWY, Lau MMC, Lau JTF.
Sleep Breath. 2023 Mar;27(1):337-344. doi: 10.1007/s11325-022-02598-y. Epub 2022 Apr 4.
PMID: 35377089

Treatment-resistant depression and risk of autoimmune diseases: evidence from a population-based cohort and nested case-control study.
Chan VKY, Luo H, Chan SSM, Lau CS, Yeung WWY, Peng K, Tong X, Lam MPS, Wong ICK, Li X.
Transl Psychiatry. 2023 Mar 3;13(1):76. doi: 10.1038/s41398-023-02383-9.
PMID: 36864045

Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review.
Man ISC, Shao R, Hou WK, Xin Li S, Liu FY, Lee M, Wing YK, Yau SY, Lee TMC.
Front Neuroendocrinol. 2023 Jan;68:101050. doi: 10.1016/j.yfrne.2022.101050. Epub 2022 Nov 18.
PMID: 36410619

Pinpointing the precise stimulation targets for brain rehabilitation in early-stage Parkinson’s disease.
Lu H, Li J, Zhang L, Meng L, Ning Y, Jiang T.
BMC Neurosci. 2023 Mar 29;24(1):24. doi: 10.1186/s12868-023-00791-7.
PMID: 36991320

Evaluating the Efficacy of Electrical Vestibular Stimulation (VeNS) on Insomnia Adults: Study Protocol of a Double-Blinded, Randomized, Sham-Controlled Trial.
Cheung T, Lam JYT, Fong KH, Cheng CP, Ho A, Sittlington J, Xiang YT, Li TMH.
Int J Environ Res Public Health. 2023 Feb 17;20(4):3577. doi: 10.3390/ijerph20043577.
PMID: 36834268

The Roles of Information Valence, Media Literacy and Perceived Information Quality on the Association Between Frequent Social Media Exposure and COVID-19 Vaccination Intention.
Xin M, Luo S, Wang S, Zhao J, Zhang G, Li L, Li L, Lau JT.
Am J Health Promot. 2023 Feb;37(2):189-199. doi: 10.1177/08901171221121292. Epub 2022 Aug 16.
PMID: 35972385

Association of accelerometer-derived circadian abnormalities and genetic risk with incidence of atrial fibrillation.
Yang L, Feng H, Ai S, Liu Y, Lei B, Chen J, Tan X, Benedict C, Wang N, Wing YK, Qi L, Zhang J.
NPJ Digit Med. 2023 Mar 4;6(1):31. doi: 10.1038/s41746-023-00781-3.
PMID: 36869222

Epidemiology, Symptomatology, and Risk Factors for Long COVID Symptoms: Population-Based, Multicenter Study.
Wong MC, Huang J, Wong YY, Wong GL, Yip TC, Chan RN, Chau SW, Ng SC, Wing YK, Chan FK.
JMIR Public Health Surveill. 2023 Mar 7;9:e42315. doi: 10.2196/42315.
PMID: 36645453

Associations of insomnia with insulin resistance traits: a cross-sectional and Mendelian Randomization study.
Wang X, Zhao C, Feng H, Li G, He L, Yang L, Liang Y, Tan X, Xu Y, Cui R, Sun Y, Guo S, Zhao G, Zhang J, Ai S.
J Clin Endocrinol Metab. 2023 Feb 16:dgad089. doi: 10.1210/clinem/dgad089. Online ahead of print.
PMID: 36794917

Early- and late-onset of isolated rapid eye movement sleep behavior disorder: A retrospective cohort study.
Zhou L, Huang B, Wang J, Chau SW, Chan JW, Zhang J, Yu MW, Tsang JC, Li SX, Mok VC, Wing YK, Liu Y.
Sleep Med. 2023 May;105:1-8. doi: 10.1016/j.sleep.2023.03.007. Epub 2023 Mar 7.
PMID: 36934616

Predictors of dropout in university students participating in an 8-week e-mail-based cognitive-behavioral therapy for insomnia intervention.
Nam H, Chang J, Trockel M, Okajima I, Yang CM, Chan NY, Li S, Suh S.
Sleep Breath. 2023 Mar;27(1):345-353. doi: 10.1007/s11325-022-02609-y. Epub 2022 Apr 12.
PMID: 35412222

Dose-response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials.
Recchia F, Leung CK, Yu AP, Leung W, Yu DJ, Fong DY, Montero D, Lee CH, Wong SHS, Siu PM.
Br J Sports Med. 2023 Jan 20:bjsports-2022-106304. doi: 10.1136/bjsports-2022-106304. Online ahead of print.
PMID: 36669870

Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study.
Chau SWH, Liu Y, Zhang J, Leung E, Chen S, Ho CL, Chan JWY, Tsang CC, Li SX, Huang B, Lam SP, Mok VC, Wing YK.
Parkinsonism Relat Disord. 2023 Feb;107:105271. doi: 10.1016/j.parkreldis.2022.105271. Epub 2022 Dec 26.
PMID: 36634468

Joint association of physical activity and sleep duration with risk of all-cause and cause-specific mortality: a population-based cohort study using accelerometry.
Liang YY, Feng H, Chen Y, Jin X, Xue H, Zhou M, Ma H, Ai S, Wing YK, Geng Q, Zhang J.
Eur J Prev Cardiol. 2023 Mar 29:zwad060. doi: 10.1093/eurjpc/zwad060. Online ahead of print.
PMID: 36990109

Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression-A Pilot Randomized Controlled Trial.
Cheung T, Li TMH, Ho YS, Kranz G, Fong KNK, Leung SF, Lam SC, Yeung WF, Lam JYT, Fong KH, Beisteiner R, Xiang YT, Cheng CPW.
Int J Environ Res Public Health. 2023 Jan 28;20(3):2333. doi: 10.3390/ijerph20032333.
PMID: 36767702

Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study.
Jin X, Chen Y, Feng H, Zhou M, Chan JWY, Liu Y, Kong APS, Tan X, Wing YK, Liang YY, Zhang J.
J Sport Health Sci. 2023 Mar 3:S2095-2546(23)00021-2. doi: 10.1016/j.jshs.2023.03.001. Online ahead of print.
PMID: 36871624

Changed epidemiology of narcolepsy before, during, and after the 2009 H1N1 pandemic: a nationwide narcolepsy surveillance network study in mainland China, 1990-2017.
Wang X, Xiao F, Wang Y, Deng X, Chen Z, Dong X, Wang W, Li C, Xu Z, Wu H, Yu H, Su C, Wang Z, Tang X, Lv Y, Li Y, Sun S, Huang J, Hao L, Wei X, Deng L, Huang YS, Zhang J, Wing YK, Zhang J, Mignot E, Han F, Yu H.
Sleep. 2023 Mar 9;46(3):zsac325. doi: 10.1093/sleep/zsac325.
PMID: 36595587

MRI-informed cortical features for brain age prediction in age-specific adulthoods.
Li J, Lu H.
Hum Brain Mapp. 2023 Feb 1;44(2):301-303. doi: 10.1002/hbm.26050. Epub 2022 Aug 16.
PMID: 35971680

Decoding the radiomic features of dorsolateral prefrontal cortex in individuals with accelerated cortical changes: implications for personalized transcranial magnetic stimulation.
Lu H, Li J, Chan SSM, Yue WWY, Lam LCW.
J Med Imaging (Bellingham). 2023 Jan;10(1):015001. doi: 10.1117/1.JMI.10.1.015001. Epub 2023 Jan 4.
PMID: 36619873

Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.
Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Penzel T, Holzinger B, Partinen M, Wing YK.
J Sleep Res. 2023 Feb;32(1):e13613. doi: 10.1111/jsr.13613. Epub 2022 Apr 26.
PMID: 35474255

Association of circadian rest-activity rhythms with cardiovascular disease and mortality in type 2 diabetes.
Yang L, Feng H, Chen J, Kwok Wing Y, Benedict C, Tan X, Zhang J.
Diabetes Res Clin Pract. 2023 Mar;197:110262. doi: 10.1016/j.diabres.2023.110262. Epub 2023 Jan 20.
PMID: 36690211

Sleep symptoms are essential features of long-COVID – Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II).
Merikanto I, Dauvilliers Y, Chung F, Wing YK, De Gennaro L, Holzinger B, Bjorvatn B, Morin CM, Penzel T, Benedict C, Koscec Bjelajac A, Chan NY, Espie CA, Hrubos-Strøm H, Inoue Y, Korman M, Landtblom AM, Léger D, Matsui K, Mota-Rolim S, Nadorff MR, Plazzi G, Reis C, Yordanova J, Partinen M.
J Sleep Res. 2023 Feb;32(1):e13754. doi: 10.1111/jsr.13754. Epub 2022 Oct 8.
PMID: 36208038

Diversity in verbal fluency performance and its associations with MRI-informed brain age matrices in normal ageing and neurocognitive disorders.
Lu H, Li J, Fung AWT, Lam LCW.
CNS Neurosci Ther. 2023 Mar 13. doi: 10.1111/cns.14144. Online ahead of print.
PMID: 36914578

The association of nocturnal enuresis with autonomic dysfunctions, mood disturbances and sleepwalking in isolated rapid eye movement sleep behavior disorder.
Lin Y, Huang B, Zhou L, Wang J, Shi T, Chau SWH, Chan JWY, Liu Y, Wing YK.
Sleep. 2023 Mar 9:zsad062. doi: 10.1093/sleep/zsad062. Online ahead of print.
PMID: 36892212

An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish.
Sy SKH, Chan DCW, Chan RCH, Lyu J, Li Z, Wong KKY, Choi CHJ, Mok VCT, Lai HM, Randlett O, Hu Y, Ko H.
Nat Commun. 2023 Jan 14;14(1):227. doi: 10.1038/s41467-023-35836-2.
PMID: 36641479

Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
Xue P, Merikanto I, Chung F, Morin CM, Espie C, Bjorvatn B, Cedernaes J, Landtblom AM, Penzel T, De Gennaro L, Holzinger B, Matsui K, Hrubos-Strøm H, Korman M, Leger D, Mota-Rolim S, Bolstad CJ, Nadorff M, Plazzi G, Reis C, Chan RNY, Wing YK, Yordanova J, Bjelajac AK, Inoue Y, Partinen M, Dauvilliers Y, Benedict C.
Transl Psychiatry. 2023 Feb 1;13(1):32. doi: 10.1038/s41398-023-02334-4.
PMID: 36726008

Effects of Tai Chi and cognitive behavioral therapy for insomnia on improving sleep in older adults: Study protocol for a non-inferiority trial.
Yu DJ, Yu AP, Li SX, Chan RNY, Fong DY, Chan DKC, Hui SS, Chung KF, Woo J, Wang C, Irwin MR, Siu PM.
J Exerc Sci Fit. 2023 Jan;21(1):67-73. doi: 10.1016/j.jesf.2022.10.012. Epub 2022 Nov 4.
PMID: 36408205

Effectiveness of one-week internet-delivered cognitive behavioral therapy for insomnia to prevent progression from acute to chronic insomnia: A two-arm, multi-center, randomized controlled trial.
Yang L, Zhang J, Luo X, Yang Y, Zhao Y, Feng F, Liu S, Zhang C, Li Z, Wang C, Wang W, Jiang F, Zhang Y, Hu Y, Su C, Wu H, Yu H, Li SX, Wing YK, Luo Y, Zhang B.
Psychiatry Res. 2023 Mar;321:115066. doi: 10.1016/j.psychres.2023.115066. Epub 2023 Jan 26.
PMID: 36716552

Bright Light Therapy for Cancer-related Fatigue in a Palliative Care Unit: A Feasibility Study.
Tang JH, Wing YK, Chan JWY, Lo RSK.
J Pain Symptom Manage. 2023 Mar;65(3):e237-e240. doi: 10.1016/j.jpainsymman.2022.10.008. Epub 2022 Oct 27.
PMID: 36441072

Isolated rapid eye movement sleep behaviour disorder: clinical and research implications.
Stefani A, Trenkwalder C, Arnulf I, Bliwise DL, Boeve BF, Inoue Y, Iranzo A, Lewis SJ, Provini F, Schenck C, Wenning GK, Wing YK, Hogl B, Videnovic A.
J Neurol Neurosurg Psychiatry. 2023 Mar 28:jnnp-2022-330913. doi: 10.1136/jnnp-2022-330913. Online ahead of print.
PMID: 36977554

The role of sleep and dreams in long-COVID.
Scarpelli S, De Santis A, Alfonsi V, Gorgoni M, Morin CM, Espie C, Merikanto I, Chung F, Penzel T, Bjorvatn B, Dauvilliers Y, Holzinger B, Wing YK, Partinen M, Plazzi G, De Gennaro L.
J Sleep Res. 2022 Nov 18:e13789. doi: 10.1111/jsr.13789. Online ahead of print.
PMID: 36398720

Is Mitochondria DNA Variation a Biomarker for AD?
Gao R, Ma SL.
Genes (Basel). 2022 Oct 3;13(10):1789. doi: 10.3390/genes13101789.
PMID: 36292674

Dementia and risk of visual impairment in Chinese older adults.
Kwok CPC, Kwok JOT, Yan RWK, Lee KKW, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW, Lee ATC.
Sci Rep. 2022 Oct 27;12(1):18033. doi: 10.1038/s41598-022-22785-x.
PMID: 36302807

Advanced Diffusion MRI for prediction of Stroke Recovery.
Hui ES.
J Magn Reson Imaging. 2022 Nov 15. doi: 10.1002/jmri.28523. Online ahead of print.
PMID: 36378071 Review.

Validation of the Sonographic Measurement of Lateral Parapharyngeal Wall Thickness in Childhood Obstructive Sleep Apnea.
Yuen HM, Lai ACY, Liu EKH, Lee MC, Chu WCW, Chan JWY, Chan NY, Wing YK, Li AM, Chan KC, Au CT.
Nat Sci Sleep. 2022 Nov 4;14:2013-2021. doi: 10.2147/NSS.S369727. eCollection 2022.
PMID: 36394067

Multi-modal intermediate integrative methods in neuropsychiatric disorders: A review.
Wang Y, Tang S, Ma R, Zamit I, Wei Y, Pan Y.
Comput Struct Biotechnol J. 2022 Nov 8;20:6149-6162. doi: 10.1016/j.csbj.2022.11.008. eCollection 2022.
PMID: 36420153

Impact of COVID-19 on the sleep-wake patterns of preschool children.
Wong OY, Au CT, Yuen HM, Yu KN, Lan QY, Chan NY, Tsang CC, Li AM, Chan KC.
Sleep Med. 2023 Jan;101:50-57. doi: 10.1016/j.sleep.2022.10.012. Epub 2022 Oct 23.
PMID: 36334501

Supportive care and symptom management in patients with advanced hematological malignancies: a literature review.
Chan KY, Chan TSY, Gill H, Chan TCW, Li CW, Au HY, Wong CY, Tsang KW, Lo RSK, Cheng BHW, Hui CH, Mok LWS, Kwok CSL, Chan ML, Sham MK.
Ann Palliat Med. 2022 Oct;11(10):3273-3291. doi: 10.21037/apm-22-691. Epub 2022 Oct 13.
PMID: 36267009

Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review.
Man ISC, Shao R, Hou WK, Xin Li S, Liu FY, Lee M, Wing YK, Yau SY, Lee TMC.
Front Neuroendocrinol. 2022 Nov 18;68:101050. doi: 10.1016/j.yfrne.2022.101050. Online ahead of print.
PMID: 36410619

Blood pressure and childhood obstructive sleep apnea: A systematic review and meta-analysis.
Ai S, Li Z, Wang S, Chen S, Chan JW, Au CT, Bao Y, Li AM, Zhang J, Chan KC, Wing YK.
Sleep Med Rev. 2022 Oct;65:101663. doi: 10.1016/j.smrv.2022.101663. Epub 2022 Aug 20.
PMID: 36087456

The impact of sleep-corrected social jetlag on mental health, behavioral problems, and daytime sleepiness in adolescents.
Chen CX, Li TMH, Zhang J, Li SX, Yu MWM, Tsang CC, Chan KCC, Au CT, Li AM, Kong APS, Chan JWY, Wing YK, Chan NY.
Sleep Med. 2022 Dec;100:494-500. doi: 10.1016/j.sleep.2022.09.027. Epub 2022 Oct 6.
PMID: 36272246

Clinical and radiomic features for predicting the treatment response of repetitive transcranial magnetic stimulation in major neurocognitive disorder: Results from a randomized controlled trial.
Lu H, Chan SSM, Ma S, Lin C, Mok VCT, Shi L, Wang D, Mak AD, Lam LCW.
Hum Brain Mapp. 2022 Dec 15;43(18):5579-5592. doi: 10.1002/hbm.26032. Epub 2022 Aug 1.
PMID: 35912517

Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol.
Cheung T, Ho YS, Fong KH, Lam YTJ, Li MH, Tse AC, Li CT, Cheng CP, Beisteiner R.
Int J Environ Res Public Health. 2022 Nov 24;19(23):15614. doi: 10.3390/ijerph192315614.
PMID: 36497688

Craniofacial Phenotyping By Photogrammetry In Chinese Prepubertal Children With Obstructive Sleep Apnea.
Yuen HM, Chan KC, Chu WCW, Chan JWY, Wing YK, Li AM, Au CT.
Sleep. 2022 Dec 3:zsac289. doi: 10.1093/sleep/zsac289. Online ahead of print.
PMID: 36462191

A forgotten sign of depression – the omega sign and its implication.
Chen J, Li CT, Li TMH, Chan NY, Chan JWY, Liu Y, Lee TMC, Wing YK.
Asian J Psychiatr. 2022 Nov 21;80:103345. doi: 10.1016/j.ajp.2022.103345. Online ahead of print.
PMID: 36423435

Sleep symptoms are essential features of long-COVID – Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II).
Merikanto I, Dauvilliers Y, Chung F, Wing YK, De Gennaro L, Holzinger B, Bjorvatn B, Morin CM, Penzel T, Benedict C, Koscec Bjelajac A, Chan NY, Espie CA, Hrubos-Strøm H, Inoue Y, Korman M, Landtblom AM, Léger D, Matsui K, Mota-Rolim S, Nadorff MR, Plazzi G, Reis C, Yordanova J, Partinen M.
J Sleep Res. 2022 Oct 8:e13754. doi: 10.1111/jsr.13754. Online ahead of print.
PMID: 36208038

Shift workers are at increased risk of severe COVID-19 compared with day workers: Results from the international COVID sleep study (ICOSS) of 7141 workers.
Bjorvatn B, Merikanto I, Reis C, Korman M, Bjelajac AK, Holzinger B, De Gennaro L, Wing YK, Morin CM, Espie CA, Benedict C, Landtblom AM, Matsui K, Hrubos-Strøm H, Mota-Rolim S, Nadorff MR, Plazzi G, Chan RNY, Partinen M, Dauvilliers Y, Chung F, Forthun I.
Chronobiol Int. 2022 Nov 22:1-9. doi: 10.1080/07420528.2022.2148182. Online ahead of print.
PMID: 36412198

Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder.
Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK, Liu Y.
J Sleep Res. 2022 Nov 21:e13791. doi: 10.1111/jsr.13791. Online ahead of print.
PMID: 36410741

Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study.
Chau SWH, Liu Y, Zhang J, Leung E, Chen S, Ho CL, Chan JWY, Tsang CC, Li SX, Huang B, Lam SP, Mok VC, Wing YK.
Parkinsonism Relat Disord. 2022 Dec 26;107:105271. doi: 10.1016/j.parkreldis.2022.105271. Online ahead of print.
PMID: 36634468

Prescription of psychotropic medications after diagnosis of cancer and the associations with risk of mortality in Chinese patients: A population-based cohort study.
Lam CS, Lee CP, Chan JWY, Cheung YT.
Asian J Psychiatr. 2022 Dec;78:103290. doi: 10.1016/j.ajp.2022.103290. Epub 2022 Oct 4.
PMID: 36209707

Early stage NSCLS patients’ prognostic prediction with multi-information using transformer and graph neural network model.
Lian J, Deng J, Hui ES, Koohi-Moghadam M, She Y, Chen C, Vardhanabhuti V.
Elife. 2022 Oct 4;11:e80547. doi: 10.7554/eLife.80547.
PMID: 36194194

Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study.
Feng H, Ho AW, Lei B, Chan JWY, Wang J, Liu Y, Tsang JCC, Chan NY, Lam SP, Merikangas KR, Ho CS, Zhang J, Wing YK.
J Affect Disord. 2022 Oct 15;315:42-47. doi: 10.1016/j.jad.2022.07.029. Epub 2022 Jul 22.
PMID: 35878843

Effects of Tai Chi and cognitive behavioral therapy for insomnia on improving sleep in older adults: Study protocol for a non-inferiority trial.
Yu DJ, Yu AP, Li SX, Chan RNY, Fong DY, Chan DKC, Hui SS, Chung KF, Woo J, Wang C, Irwin MR, Siu PM.
J Exerc Sci Fit. 2023 Jan;21(1):67-73. doi: 10.1016/j.jesf.2022.10.012. Epub 2022 Nov 4.
PMID: 36408205

Inpatient stay for older adults: a double-edged sword for cognition?
Lee ATC, Chiu HFK.
Int Psychogeriatr. 2022 Nov;34(11):953-954. doi: 10.1017/S1041610221001137. Epub 2021 Aug 16.
PMID: 34392863

Bright Light Therapy for Cancer-related Fatigue in a Palliative Care Unit: A Feasibility Study.
Tang JH, Wing YK, Chan JWY, Lo RSK.
J Pain Symptom Manage. 2022 Oct 27:S0885-3924(22)00948-4. doi: 10.1016/j.jpainsymman.2022.10.008. Online ahead of print.
PMID: 36441072

Antibody stabilization for thermally accelerated deep immunostaining.
Lai HM, Tang Y, Lau ZYH, Campbell RAA, Yau JCN, Chan CCY, Chan DCW, Wong TY, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H.
Nat Methods. 2022 Sep;19(9):1137-1146. doi: 10.1038/s41592-022-01569-1. Epub 2022 Sep 1. PMID: 36050489

The associations of insomnia symptoms with daytime behavior and cognitive functioning in children with attention-deficit/hyperactivity disorder.
Li X, Shea KSC, Chiu WV, Lau FLF, Wong CKD, Yu WMM, Li AM, Wing YK, Lai YCK, Li SX.
J Clin Sleep Med. 2022 Aug 1;18(8):2029-2039. doi: 10.5664/jcsm.10060. PMID: 35638119

Perspective of palliative care in radiation-oncology.
Chan KY, Gill H, Li CW, Au HY, Wong CY, Chan ML.
Ann Palliat Med. 2022 Aug;11(8):2558-2561. doi: 10.21037/apm-22-842. Epub 2022 Aug 8.  PMID: 35948474

Blood pressure and childhood obstructive sleep apnea: A systematic review and meta-analysis.
Ai S, Li Z, Wang S, Chen S, Chan JW, Au CT, Bao Y, Li AM, Zhang J, Chan KC, Wing YK.
Sleep Med Rev. 2022 Aug 20;65:101663. doi: 10.1016/j.smrv.2022.101663. Online ahead of print.  PMID: 36087456 Review.

Clinical and radiomic features for predicting the treatment response of repetitive transcranial magnetic stimulation in major neurocognitive disorder: Results from a randomized controlled trial.
Lu H, Chan SSM, Ma S, Lin C, Mok VCT, Shi L, Wang D, Mak AD, Lam LCW.
Hum Brain Mapp. 2022 Aug 1. doi: 10.1002/hbm.26032. Online ahead of print.  PMID: 35912517

Non-alcoholic fatty liver disease, sleep behaviors, and incident type 2 diabetes.
Zhang H, Wang Y, Chen C, Wang B, Chen J, Tan X, Xia F, Zhang J, Lu Y, Wang N.
J Gastroenterol Hepatol. 2022 Aug;37(8):1633-1640. doi: 10.1111/jgh.15877. Epub 2022 May 10. PMID: 35499342

A 10-Year Community-Based Study of Leucine-Rich Repeat Kinase 2 G2385R Carriers’ Conversion to Parkinson’s Disease.
Wang P, Pan J, Luo Q, Chen J, Tang H, Chen S, Ma J.
Mov Disord. 2022 Aug;37(8):1767-1772. doi: 10.1002/mds.29127. Epub 2022 Jun 22.  PMID: 35733392

Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study.
Wang J, Chau SWH, Lam SP, Liu Y, Zhang J, Chan NY, Cheung MMS, Yu MWM, Tsang JCT, Chan JWY, Huang B, Li SX, Mok V, Wing YK.
J Neurol Neurosurg Psychiatry. 2022 Sep;93(9):1010-1017. doi: 10.1136/jnnp-2021-327460. Epub 2021 Nov 11. PMID: 34764151

Has the COVID-19 Pandemic Traumatized Us Collectively? The Impact of the COVID-19 Pandemic on Mental Health and Sleep Factors via Traumatization: A Multinational Survey. 
Holzinger B, Nierwetberg F, Chung F, Bolstad CJ, Bjorvatn B, Chan NY, Dauvilliers Y, Espie CA, Han F, Inoue Y, Leger D, Macêdo T, Matsui K, Merikanto I, Morin CM, Mota-Rolim SA, Partinen M, Plazzi G, Penzel T, Sieminski M, Wing YK, Scarpelli S, Nadorff MR, De Gennaro L.
Nat Sci Sleep. 2022 Aug 26;14:1469-1483. doi: 10.2147/NSS.S368147. eCollection 2022.  PMID: 36052103

Childhood adversities and suicidal thoughts and behaviors among first-year college students: results from the WMH-ICS initiative.
Mortier P, Alonso J, Auerbach RP, Bantjes J, Benjet C, Bruffaerts R, Cuijpers P, Ebert DD, Green JG, Hasking P, Karyotaki E, Kiekens G, Mak A, Nock MK, O’Neill S, Pinder-Amaker S, Sampson NA, Stein DJ, Vilagut G, Wilks C, Zaslavsky AM, Mair P, Kessler RC; WHO WMH-ICS Collaborators.
Soc Psychiatry Psychiatr Epidemiol. 2022 Aug;57(8):1591-1601. doi: 10.1007/s00127-021-02151-4. Epub 2021 Aug 23. PMID: 34424350

Prediction of Dropout in a Randomized Controlled Trial of Adjunctive Light Treatment in Patients with Non-Seasonal Depression and Evening Chronotype.
Chan JWY, Li SX, Chau SWH, Chan NY, Zhang J, Wing YK.
Clocks Sleep. 2022 Jul 27;4(3):346-357. doi: 10.3390/clockssleep4030029. PMID: 35997383

Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study.
Feng H, Ho AW, Lei B, Chan JWY, Wang J, Liu Y, Tsang JCC, Chan NY, Lam SP, Merikangas KR, Ho CS, Zhang J, Wing YK.
J Affect Disord. 2022 Oct 15;315:42-47. doi: 10.1016/j.jad.2022.07.029. Epub 2022 Jul 22. PMID: 35878843

Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder.
Zhou L, Chau SWH, Liu Y, Wang J, Zhang J, Chan NY, Chan JWY, Huang B, Chen S, Li SX, Mok VCT, Wing YK.
NPJ Parkinsons Dis. 2022 Jul 14;8(1):91. doi: 10.1038/s41531-022-00356-1. PMID: 35835768

Executive function as a generalized determinant of psychopathology and functional outcome in school-aged autism spectrum disorder: a case-control study.
Wong OWH, Barzilay R, Lam AMW, Chan S, Calkins ME, Gur RE, Gur RC.
Psychol Med. 2022 Aug 1:1-11. doi: 10.1017/S0033291722001787. Online ahead of print. PMID: 35912846

Is sleep quality a potential predictor of neurocognitive disorders? A 6-year follow-up study in Chinese older adults.
Lai VKY, Fung AWT, Lam LCW, Lee ATC.
Int J Geriatr Psychiatry. 2022 Aug;37(8). doi: 10.1002/gps.5783. PMID: 35844091

Are Care-Recipient Outcomes Attributable to Improved Caregiver Well-Being? A Cluster-Randomized Controlled Trial of Benefit-Finding Intervention.
Cheng ST, Chan WC, Lam LCW.
Am J Geriatr Psychiatry. 2022 Aug;30(8):903-913. doi: 10.1016/j.jagp.2021.08.009. Epub 2021 Aug 28.  PMID: 34563429 Clinical Trial.

Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long-COVID – A multinational ICOSS study.
Merikanto I, Dauvilliers Y, Chung F, Holzinger B, De Gennaro L, Wing YK, Korman M, Partinen M; 2nd ICOSS members.
J Sleep Res. 2022 Aug;31(4):e13542. doi: 10.1111/jsr.13542. Epub 2021 Dec 28. PMID: 34964184

Editorial: Neuroimaging and informatics for successful aging.
Nakai T, Ho ETW, Müller H, Yang FG, Lu H.
Front Hum Neurosci. 2022 Jul 28;16:976524. doi: 10.3389/fnhum.2022.976524. eCollection 2022.  PMID: 35967000

Elder abuse among Chinese older adults: global lessons.
Peisah C, Tsoh J, Chiu HF.
Int Psychogeriatr. 2022 Aug;34(8):689-690. doi: 10.1017/S1041610222000266. Epub 2022 Mar 15. PMID: 35287779

MRI-informed cortical features for brain age prediction in age-specific adulthoods.
Li J, Lu H.
Hum Brain Mapp. 2022 Aug 16. doi: 10.1002/hbm.26050. Online ahead of print.  PMID: 35971680

Common mental disorders during the COVID-19 pandemic in Hong Kong: Age-related differences and implications for dementia risk.
Kwok JOT, Yan RWK, Kwok CPC, Cheng GWH, Lin C, Wong BHC, Cheng ST, Lee ATC, Lam LCW.
Front Psychiatry. 2022 Sep 14;13:909162. doi: 10.3389/fpsyt.2022.909162. eCollection 2022.  PMID: 36186878

Effects of a blended classroom-based intervention on aerobic fitness, motor skills, inhibition, and daytime sleepiness among Hong Kong children.
Li MH, Sit CHP, Wong SHS, Wing YK, Ng CK, Rudd J, Chow JY, Sum RKW.
Front Public Health. 2022 Sep 20;10:944423. doi: 10.3389/fpubh.2022.944423. eCollection 2022.  PMID: 36203680

Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective Longitudinal Case-Control Study.
Liu Y, Zhang J, Chau SWH, Man Yu MW, Chan NY, Chan JWY, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK.
Neurology. 2022 Aug 9;99(6):e627-e637. doi: 10.1212/WNL.0000000000200707. Epub 2022 May 12.  PMID: 35550550

Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study. 
Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK.
Neurology. 2022 May 12:10.1212/WNL.0000000000200707. doi: 10.1212/WNL.0000000000200707. Online ahead of print.  PMID: 35550550

Validation of the Chinese version of the Munich Chronotype Questionnaire (MCTQ^HK) in Hong Kong Chinese youths.
Cheung FTW, Ho AWY, Chan JWY, Li X, Chan NY, Zhang J, Ho CS, Wing YK, Li SX.
Chronobiol Int. 2022 May;39(5):678-689. doi: 10.1080/07420528.2022.2025821. Epub 2022 Jan 27.  PMID: 35086397

Selectively disrupted sensorimotor circuits in chronic stroke with hand dysfunction.
Liu F, Chen C, Hong W, Bai Z, Wang S, Lu H, Lin Q, Zhao Z, Tang C.
CNS Neurosci Ther. 2022 May;28(5):677-689. doi: 10.1111/cns.13799. Epub 2022 Jan 10.  PMID: 35005843

The Associations of Electronic Media Use With Sleep and Circadian Problems, Social, Emotional and Behavioral Difficulties in Adolescents.
Li TMH, Chan NY, Li CT, Chen J, Chan JWY, Liu Y, Li SX, Li AM, Zhang J, Wing YK.
Front Psychiatry. 2022 Jun 9;13:892583. doi: 10.3389/fpsyt.2022.892583. eCollection 2022.  PMID: 35757219

The associations of insomnia symptoms with daytime behavior and cognitive functioning in children with attention deficit hyperactivity disorder.
Li X, Shea KSC, Chiu WV, Lau FLF, Wong CKD, Yu WMM, Li AM, Wing YK, Lai YCK, Li SX.
J Clin Sleep Med. 2022 Jun 1. doi: 10.5664/jcsm.10060. Online ahead of print.  PMID: 35638119

Disentangling the relationship of gut microbiota, functional gastrointestinal disorders and autism: a case-control study on prepubertal Chinese boys.
Wong OWH, Lam AMW, Or BPN, Mo FYM, Shea CKS, Lai KYC, Ma SL, Hung SF, Chan S, Kwong TNY, Wong S, Leung PWL.
Sci Rep. 2022 Jun 23;12(1):10659. doi: 10.1038/s41598-022-14785-8.  PMID: 35739175

The psychological impact of COVID-19 pandemic on medical staff in Guangdong, China: a cross-sectional study.
Wang H, Huang D, Huang H, Zhang J, Guo L, Liu Y, Ma H, Geng Q.
Psychol Med. 2022 Apr;52(5):884-892. doi: 10.1017/S0033291720002561. Epub 2020 Jul 6.  PMID: 32624037

Comprehensive histological imaging of native microbiota in human glioma.
Zhao J, He D, Lai HM, Xu Y, Luo Y, Li T, Liang J, Yang X, Guo L, Ke Y, Zhou H, Wu W, Guo H, Sun H.
J Biophotonics. 2022 Apr;15(4):e202100351. doi: 10.1002/jbio.202100351. Epub 2022 Jan 3.  PMID: 34936211

Depression duration and risk of incident cardiovascular disease: A population-based six-year cohort study.
Zhang Y, Li X, Chan VKY, Luo H, Chan SSM, Wong GHY, Wong ICK, Lum TYS.
J Affect Disord. 2022 May 15;305:188-195. doi: 10.1016/j.jad.2022.03.005. Epub 2022 Mar 10.  PMID: 35283180

Non-alcoholic fatty liver disease, sleep behaviors, and incident type 2 diabetes.
Zhang H, Wang Y, Chen C, Wang B, Chen J, Tan X, Xia F, Zhang J, Lu Y, Wang N.
J Gastroenterol Hepatol. 2022 May 2. doi: 10.1111/jgh.15877. Online ahead of print.  PMID: 35499342

Cost-effectiveness of internet-supported cognitive behavioral therapy for university students with anxiety symptoms: A Markov-model analysis.
You JHS, Luk SWC, Chow DYW, Jiang X, Mak ADP, Mak WWS.
PLoS One. 2022 May 5;17(5):e0268061. doi: 10.1371/journal.pone.0268061. eCollection 2022.  PMID: 35511888

Predictors of dropout in university students participating in an 8-week e-mail-based cognitive-behavioral therapy for insomnia intervention.
Nam H, Chang J, Trockel M, Okajima I, Yang CM, Chan NY, Li S, Suh S.
Sleep Breath. 2022 Apr 12. doi: 10.1007/s11325-022-02609-y. Online ahead of print.  PMID: 35412222

Effects of glycemic traits on left ventricular structure and function: a mendelian randomization study.
Ai S, Wang X, Wang S, Zhao Y, Guo S, Li G, Chen Z, Lin F, Guo S, Li Y, Zhang J, Zhao G.
Cardiovasc Diabetol. 2022 Jun 17;21(1):109. doi: 10.1186/s12933-022-01540-6.  PMID: 35715813

Inequalities in Psychiatric Morbidity in Hong Kong and Strategies for Mitigation.
Chan SM, Lam LC, Law WY, Hung SF, Chan WC, Chen EY, Chung GK, Chan YH, Chung RY, Wong H, Yeoh EK, Woo J.
Int J Environ Res Public Health. 2022 Jun 9;19(12):7095. doi: 10.3390/ijerph19127095.  PMID: 35742339

Mortality-causing mechanisms and healthcare resource utilisation of treatment-resistant depression: A six-year population-based cohort study.
Chan VK, Cheung EC, Chan SS, Knapp M, Hayes JF, Fan M, Lai FT, Luo H, Lum T, Wong RS, Lau LK, Wan EY, Wong GH, Chan EW, Ip P, Wong IC, Li X.
Lancet Reg Health West Pac. 2022 Mar 15;22:100426. doi: 10.1016/j.lanwpc.2022.100426. eCollection 2022 May.  PMID: 35637863

Efficacy of Email-delivered Versus Face-to-face Group Cognitive Behavioral Therapy for Insomnia in Youths: A Randomized Controlled Trial.
Chan NY, Lam SP, Zhang J, Chan JWY, Yu MMW, Suh S, Yang CM, Okajima I, Li AM, Wing YK, Li SX.
J Adolesc Health. 2022 May;70(5):763-773. doi: 10.1016/j.jadohealth.2021.11.005. Epub 2022 Feb 4.  PMID: 35125265

Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study.
Liu Y, Partinen E, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M, Wing YK.
J Sleep Res. 2022 Apr 26:10.1111/jsr.13613. doi: 10.1111/jsr.13613. Online ahead of print.  PMID: 35474255

A 10-Year Community-Based Study of Leucine-Rich Repeat Kinase 2 G2385R Carriers’ Conversion to Parkinson’s Disease.
Wang P, Pan J, Luo Q, Chen J, Tang H, Chen S, Ma J.
Mov Disord. 2022 Jun 22. doi: 10.1002/mds.29127. Online ahead of print.  PMID: 35733392

Night Shift Work, MTNR1B rs10830963 Polymorphism, and Prostate Cancer Risk: Findings from a Prospective, Population-Based Study.
Yang L, Chen J, Feng H, Ai S, Liu Y, Chen X, Lei B, Chan JWY, Chau SWH, Tse LA, Ho AW, Ho CS, Wing YK, Zhang J.
Cancer Epidemiol Biomarkers Prev. 2022 Apr 1;31(4):728-735. doi: 10.1158/1055-9965.EPI-21-1108.  PMID: 35064058

Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial.
Chan JW, Lam SP, Li SX, Chau SW, Chan SY, Chan NY, Zhang JH, Wing YK.
Psychol Med. 2022 Jun;52(8):1448-1457. doi: 10.1017/S0033291720003232. Epub 2020 Sep 14.  PMID: 32924897

Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis.
Zavaliangos-Petropulu A, Lo B, Donnelly MR, Schweighofer N, Lohse K, Jahanshad N, Barisano G, Banaj N, Borich MR, Boyd LA, Buetefisch CM, Byblow WD, Cassidy JM, Charalambous CC, Conforto AB, DiCarlo JA, Dula AN, Egorova-Brumley N, Etherton MR, Feng W, Fercho KA, Geranmayeh F, Hanlon CA, Hayward KS, Hordacre B, Kautz SA, Khlif MS, Kim H, Kuceyeski A, Lin DJ, Liu J, Lotze M, MacIntosh BJ, Margetis JL, Mohamed FB, Piras F, Ramos-Murguialday A, Revill KP, Roberts PS, Robertson AD, Schambra HM, Seo NJ, Shiroishi MS, Stinear CM, Soekadar SR, Spalletta G, Taga M, Tang WK, Thielman GT, Vecchio D, Ward NS, Westlye LT, Werden E, Winstein C, Wittenberg GF, Wolf SL, Wong KA, Yu C, Brodtmann A, Cramer SC, Thompson PM, Liew SL.
J Am Heart Assoc. 2022 May 17;11(10):e025109. doi: 10.1161/JAHA.121.025109. Epub 2022 May 16.  PMID: 35574963

Increasing participation in habitual intellectual activities on modulating functional connectivity of default mode network among older adults at risk of dementia: study protocol of a randomized controlled trial.
Yan RWK, Kwok CPC, Kwok JOT, Lee KKW, Lu H, Chu WCW, Kwok TCY, Lam LCW, Lee ATC.
Trials. 2022 Apr 14;23(1):306. doi: 10.1186/s13063-022-06271-3.  PMID: 35422056

Correction: Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.
Rao S, Yin L, Xiang Y, So HC.
Transl Psychiatry. 2022 Jun 7;12(1):237. doi: 10.1038/s41398-022-02012-x.  PMID: 35672296

School-Based Mental Health Initiative: Potentials and Challenges for Child and Adolescent Mental Health.
Lai KYC, Hung SF, Lee HWS, Leung PWL.
Front Psychiatry. 2022 Jun 9;13:866323. doi: 10.3389/fpsyt.2022.866323. eCollection 2022. PMID: 35757210

Clinical considerations when using assessment tools to identify depression in older adults with mild cognitive impairment.
Lee ATC, Chiu HFK, Peisah C.
Int Psychogeriatr. 2022 May;34(5):413-416. doi: 10.1017/S1041610222000424. Epub 2022 Apr 25.  PMID: 35465861

Combined physical exercise-working memory training on slowing down cognitive decline in elders with mild clinical Alzheimer disease: a randomised controlled study (abridged secondary publication).
Lam LCW, Chan WC, Kwok TCY, Lee JSW, Yu BML, Lee S, Lee ATC, Ma SL, Cheng ST.
Hong Kong Med J. 2022 Jun;28 Suppl 3(3):28-30.  PMID: 35701227

Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Koopmans F, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson EG, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh BZ, Alptekin K, Als TD, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo MH, Bacanu SA, Bass NJ, Begemann M, Belliveau RA, Bene J, Benyamin B, Bergen SE, Blasi G, Bobes J, Bonassi S, Braun A, Bressan RA, Bromet EJ, Bruggeman R, Buckley PF, Buckner RL, Bybjerg-Grauholm J, Cahn W, Cairns MJ, Calkins ME, Carr VJ, Castle D, Catts SV, Chambert KD, Chan RCK, Chaumette B, Cheng W, Cheung EFC, Chong SA, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis KL, de Haan L, Degenhardt F, DeLisi LE, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson JG, Fañanás L, Faraone SV, Fiorentino A, Forstner A, Frank J, Freimer NB, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon ES, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein JI, González Peñas J, González-Pinto A, Gopal S, Gratten J, Green MF, Greenwood TA, Guillin O, Gülöksüz S, Gur RE, Gur RC, Gutiérrez B, Hahn E, Hakonarson H, Haroutunian V, Hartmann AM, Harvey C, Hayward C, Henskens FA, Herms S, Hoffmann P, Howrigan DP, Ikeda M, Iyegbe C, Joa I, Julià A, Kähler AK, Kam-Thong T, Kamatani Y, Karachanak-Yankova S, Kebir O, Keller MC, Kelly BJ, Khrunin A, Kim SW, Klovins J, Kondratiev N, Konte B, Kraft J, Kubo M, Kučinskas V, Kučinskiene ZA, Kusumawardhani A, Kuzelova-Ptackova H, Landi S, Lazzeroni LC, Lee PH, Legge SE, Lehrer DS, Lencer R, Lerer B, Li M, Lieberman J, Light GA, Limborska S, Liu CM, Lönnqvist J, Loughland CM, Lubinski J, Luykx JJ, Lynham A, Macek M Jr, Mackinnon A, Magnusson PKE, Maher BS, Maier W, Malaspina D, Mallet J, Marder SR, Marsal S, Martin AR, Martorell L, Mattheisen M, McCarley RW, McDonald C, McGrath JJ, Medeiros H, Meier S, Melegh B, Melle I, Mesholam-Gately RI, Metspalu A, Michie PT, Milani L, Milanova V, Mitjans M, Molden E, Molina E, Molto MD, Mondelli V, Moreno C, Morley CP, Muntané G, Murphy KC, Myin-Germeys I, Nenadić I, Nestadt G, Nikitina-Zake L, Noto C, Nuechterlein KH, O’Brien NL, O’Neill FA, Oh SY, Olincy A, Ota VK, Pantelis C, Papadimitriou GN, Parellada M, Paunio T, Pellegrino R, Periyasamy S, Perkins DO, Pfuhlmann B, Pietiläinen O, Pimm J, Porteous D, Powell J, Quattrone D, Quested D, Radant AD, Rampino A, Rapaport MH, Rautanen A, Reichenberg A, Roe C, Roffman JL, Roth J, Rothermundt M, Rutten BPF, Saker-Delye S, Salomaa V, Sanjuan J, Santoro ML, Savitz A, Schall U, Scott RJ, Seidman LJ, Sharp SI, Shi J, Siever LJ, Sigurdsson E, Sim K, Skarabis N, Slominsky P, So HC, Sobell JL, Söderman E, Stain HJ, Steen NE, Steixner-Kumar AA, Stögmann E, Stone WS, Straub RE, Streit F, Strengman E, Stroup TS, Subramaniam M, Sugar CA, Suvisaari J, Svrakic DM, Swerdlow NR, Szatkiewicz JP, Ta TMT, Takahashi A, Terao C, Thibaut F, Toncheva D, Tooney PA, Torretta S, Tosato S, Tura GB, Turetsky BI, Üçok A, Vaaler A, van Amelsvoort T, van Winkel R, Veijola J, Waddington J, Walter H, Waterreus A, Webb BT, Weiser M, Williams NM, Witt SH, Wormley BK, Wu JQ, Xu Z, Yolken R, Zai CC, Zhou W, Zhu F, Zimprich F, Atbaşoğlu EC, Ayub M, Benner C, Bertolino A, Black DW, Bray NJ, Breen G, Buccola NG, Byerley WF, Chen WJ, Cloninger CR, Crespo-Facorro B, Donohoe G, Freedman R, Galletly C, Gandal MJ, Gennarelli M, Hougaard DM, Hwu HG, Jablensky AV, McCarroll SA, Moran JL, Mors O, Mortensen PB, Müller-Myhsok B, Neil AL, Nordentoft M, Pato MT, Petryshen TL, Pirinen M, Pulver AE, Schulze TG, Silverman JM, Smoller JW, Stahl EA, Tsuang DW, Vilella E, Wang SH, Xu S; Indonesia Schizophrenia Consortium; PsychENCODE; Psychosis Endophenotypes International Consortium; SynGO Consortium, Adolfsson R, Arango C, Baune BT, Belangero SI, Børglum AD, Braff D, Bramon E, Buxbaum JD, Campion D, Cervilla JA, Cichon S, Collier DA, Corvin A, Curtis D, Forti MD, Domenici E, Ehrenreich H, Escott-Price V, Esko T, Fanous AH, Gareeva A, Gawlik M, Gejman PV, Gill M, Glatt SJ, Golimbet V, Hong KS, Hultman CM, Hyman SE, Iwata N, Jönsson EG, Kahn RS, Kennedy JL, Khusnutdinova E, Kirov G, Knowles JA, Krebs MO, Laurent-Levinson C, Lee J, Lencz T, Levinson DF, Li QS, Liu J, Malhotra AK, Malhotra D, McIntosh A, McQuillin A, Menezes PR, Morgan VA, Morris DW, Mowry BJ, Murray RM, Nimgaonkar V, Nöthen MM, Ophoff RA, Paciga SA, Palotie A, Pato CN, Qin S, Rietschel M, Riley BP, Rivera M, Rujescu D, Saka MC, Sanders AR, Schwab SG, Serretti A, Sham PC, Shi Y, St Clair D, Stefánsson H, Stefansson K, Tsuang MT, van Os J, Vawter MP, Weinberger DR, Werge T, Wildenauer DB, Yu X, Yue W, Holmans PA, Pocklington AJ, Roussos P, Vassos E, Verhage M, Visscher PM, Yang J, Posthuma D, Andreassen OA, Kendler KS, Owen MJ, Wray NR, Daly MJ, Huang H, Neale BM, Sullivan PF, Ripke S, Walters JTR, O’Donovan MC; Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Nature. 2022 Apr;604(7906):502-508. doi: 10.1038/s41586-022-04434-5. Epub 2022 Apr 8.  PMID: 35396580

Dr CHAU Steven Wai Ho was interviewed in TVB news programme reated to Brain Fog “腦霧” – Neuropsychiatric ’Long-COVID’

A bidirectional association between internet addiction and depression: A large-sample longitudinal study among Chinese university students.
Yang X, Guo WJ, Tao YJ, Meng YJ, Wang HY, Li XJ, Zhang YM, Zeng JK, Tang WJ, Wang Q, Deng W, Zhao LS, Ma XH, Li ML, Xu JJ, Li J, Liu YS, Tang Z, Du XD, Hao W, Coid JW, Lee S, Greenshaw AJ, Li T.
J Affect Disord. 2022 Feb 15;299:416-424. doi: 10.1016/j.jad.2021.12.013. Epub 2021 Dec 11.
PMID: 34906641

Sleep Patterns, Genetic Susceptibility, and Incident Chronic Kidney Disease: A Prospective Study of 370 671 Participants.
Zhang H, Wang B, Chen C, Sun Y, Chen J, Tan X, Xia F, Zhang J, Lu Y, Wang N.
Front Neurosci. 2022 Jan 31;16:725478. doi: 10.3389/fnins.2022.725478. eCollection 2022.
PMID: 35173575

Protocol for a prospective open-label clinical trial to investigate the utility of concurrent TBS/fNIRS for antidepressant treatment optimisation.
Kan RLD, Mak ADP, Chan SKW, Zhang BBB, Fong KNK, Kranz GS.
BMJ Open. 2022 Feb 10;12(2):e053896. doi: 10.1136/bmjopen-2021-053896.
PMID: 35144953

Clinical and behavior characteristics of individuals who used ketamine.
Lee TS, Liu YH, Huang YJ, Tang WK, Wang Y, Hu S, Lin CP, Li CR, Hung CC.
Sci Rep. 2022 Jan 17;12(1):801. doi: 10.1038/s41598-022-04832-9.
PMID: 35039593

Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.
Chan JWY, Chan NY, Li SX, Lam SP, Chau SWH, Liu Y, Zhang J, Wing YK.
J Clin Sleep Med. 2022 Feb 1;18(2):523-531. doi: 10.5664/jcsm.9648.
PMID: 34534071

Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic-multinational study on 19 267 adults.
Merikanto I, Kortesoja L, Benedict C, Chung F, Cedernaes J, Espie CA, Morin CM, Dauvilliers Y, Partinen M, De Gennaro L, Wing YK, Chan NY, Inoue Y, Matsui K, Holzinger B, Plazzi G, Mota-Rolim SA, Leger D, Penzel T, Bjorvatn B.
Sleep. 2022 Feb 14;45(2):zsab216. doi: 10.1093/sleep/zsab216.
PMID: 34432058

Examining family pre-pandemic influences on adolescent psychosocial wellbeing during the COVID-19 pandemic.
Wong RS, Tung KTS, Li X, Chui CS, Tso WWY, Lee TMC, Chan KL, Wing YK, Fu KW, Wong ICK, Lp P.
Curr Psychol. 2022 Jan 22:1-11. doi: 10.1007/s12144-022-02736-5. Online ahead of print.
PMID: 35095244

Efficacy of Email-delivered Versus Face-to-face Group Cognitive Behavioral Therapy for Insomnia in Youths: A Randomized Controlled Trial.
Chan NY, Lam SP, Zhang J, Chan JWY, Yu MMW, Suh S, Yang CM, Okajima I, Li AM, Wing YK, Li SX.
J Adolesc Health. 2022 Feb 3:S1054-139X(21)00574-7. doi: 10.1016/j.jadohealth.2021.11.005. Online ahead of print.
PMID: 35125265

Large-scale network dysfunction in α-Synucleinopathy: A meta-analysis of resting-state functional connectivity.
Tang S, Wang Y, Liu Y, Chau SW, Chan JW, Chu WC, Abrigo JM, Mok VC, Wing YK.
EBioMedicine. 2022 Mar;77:103915. doi: 10.1016/j.ebiom.2022.103915. Epub 2022 Mar 5.
PMID: 35259574

Sleep Complaints Among School Children.
Chan NY, Au CT, Li SX, Wing YK.
Sleep Med Clin. 2022 Mar;17(1):53-65. doi: 10.1016/j.jsmc.2021.10.003.
PMID: 35216761

Validation of the Chinese version of the Munich Chronotype Questionnaire (MCTQ^HK) in Hong Kong Chinese youths.
Cheung FTW, Ho AWY, Chan JWY, Li X, Chan NY, Zhang J, Ho CS, Wing YK, Li SX.
Chronobiol Int. 2022 Jan 27:1-12. doi: 10.1080/07420528.2022.2025821. Online ahead of print.
PMID: 35086397

Neural response to rewards in youths with insomnia.
Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX.
Sleep. 2022 Feb 14;45(2):zsab238. doi: 10.1093/sleep/zsab238.
PMID: 34604904

Changes in Mental Health among Psychiatric Patients during the COVID-19 Pandemic in Hong Kong-A Cross-Sectional Study.
Li JT, Lee CP, Tang WK.
Int J Environ Res Public Health. 2022 Jan 21;19(3):1181. doi: 10.3390/ijerph19031181.
PMID: 35162205

The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke.
Liew SL, Zavaliangos-Petropulu A, Jahanshad N, Lang CE, Hayward KS, Lohse KR, Juliano JM, Assogna F, Baugh LA, Bhattacharya AK, Bigjahan B, Borich MR, Boyd LA, Brodtmann A, Buetefisch CM, Byblow WD, Cassidy JM, Conforto AB, Craddock RC, Dimyan MA, Dula AN, Ermer E, Etherton MR, Fercho KA, Gregory CM, Hadidchi S, Holguin JA, Hwang DH, Jung S, Kautz SA, Khlif MS, Khoshab N, Kim B, Kim H, Kuceyeski A, Lotze M, MacIntosh BJ, Margetis JL, Mohamed FB, Piras F, Ramos-Murguialday A, Richard G, Roberts P, Robertson AD, Rondina JM, Rost NS, Sanossian N, Schweighofer N, Seo NJ, Shiroishi MS, Soekadar SR, Spalletta G, Stinear CM, Suri A, Tang WKW, Thielman GT, Vecchio D, Villringer A, Ward NS, Werden E, Westlye LT, Winstein C, Wittenberg GF, Wong KA, Yu C, Cramer SC, Thompson PM.
Hum Brain Mapp. 2022 Jan;43(1):129-148. doi: 10.1002/hbm.25015. Epub 2020 Apr 20.
PMID: 32310331

Perceived Social Support and Depression Among Occupational Therapists in Hong Kong During COVID-19 Pandemic.
Chan MH, Lee ATC.
East Asian Arch Psychiatry. 2022 Mar;32(1):17-21. doi: 10.12809/eaap2205.
PMID: 35332106

Nightmares in People with COVID-19: Did Coronavirus Infect Our Dreams?
Scarpelli S, Nadorff MR, Bjorvatn B, Chung F, Dauvilliers Y, Espie CA, Inoue Y, Matsui K, Merikanto I, Morin CM, Penzel T, Sieminski M, Fang H, Macêdo T, Mota-Rolim SA, Leger D, Plazzi G, Chan NY, Partinen M, Bolstad CJ, Holzinger B, De Gennaro L.
Nat Sci Sleep. 2022 Jan 24;14:93-108. doi: 10.2147/NSS.S344299. eCollection 2022.
PMID: 35115852

Dispositional Mindfulness and Psychotic Symptoms in Schizophrenia Spectrum Disorders: The Mediating Roles of Rumination and Negative Emotion.
Lam AHY, Cheung YTD, Wong KH, Leung SF, Chien WT.
Neuropsychiatr Dis Treat. 2022 Jan 11;18:75-85. doi: 10.2147/NDT.S338133. eCollection 2022.
PMID: 35046658

Depression duration and risk of incident cardiovascular disease: A population-based six-year cohort study.
Zhang Y, Li X, Chan VKY, Luo H, Chan SSM, Wong GHY, Wong ICK, Lum TYS.
J Affect Disord. 2022 May 15;305:188-195. doi: 10.1016/j.jad.2022.03.005. Epub 2022 Mar 10.
PMID: 35283180

Neurophysiological and behavioral effects of multisession prefrontal tDCS and concurrent cognitive remediation training in patients with autism spectrum disorder (ASD): A double-blind, randomized controlled fNIRS study.
Han YMY, Chan MMY, Shea CKS, Lai OL, Krishnamurthy K, Cheung MC, Chan AS.
Brain Stimul. 2022 Mar-Apr;15(2):414-425. doi: 10.1016/j.brs.2022.02.004. Epub 2022 Feb 15.
PMID: 35181532

Adjunctive light treatment in major depressive disorder among evening chronotype: a randomised controlled trial (abridged secondary publication).
Wing YK, Chan JWY, Lam JSP, Zhang J.
Hong Kong Med J. 2022 Feb;28 Suppl 1(1):19-22.
PMID: 35260511

Late-life longitudinal blood pressure trajectories as predictor of dementia.
Lee ATC, Fung AWT, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
Sci Rep. 2022 Jan 31;12(1):1630. doi: 10.1038/s41598-022-05680-3.
PMID: 35102219

Comprehensive histological imaging of native microbiota in human glioma.
Zhao J, He D, Lai HM, Xu Y, Luo Y, Li T, Liang J, Yang X, Guo L, Ke Y, Zhou H, Wu W, Guo H, Sun H.
J Biophotonics. 2022 Apr;15(4):e202100351. doi: 10.1002/jbio.202100351. Epub 2022 Jan 3.
PMID: 34936211

Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach.
Zhao K, Shi Y, So HC.
Pharmaceutics. 2022 Jan 20;14(2):234. doi: 10.3390/pharmaceutics14020234.
PMID: 35213968

Concurrent anodal transcranial direct current stimulation (tDCS) with cognitive training to improve cognition in schizophrenia.
Lo KYH, Hopman HJ, Chan SC, Chau WHS, Cheng PWC, Cheung KY, Lam HHD, Mo YM, Tse LC, Wong WHO, Wong YC, Chan SMS.
Schizophr Res. 2022 Mar;241:184-186. doi: 10.1016/j.schres.2022.01.026. Epub 2022 Feb 5.
PMID: 35131597

Causal relationships between blood lipids and depression phenotypes: a Mendelian randomisation analysis.
So HC, Chau CK, Cheng YY, Sham PC.
Psychol Med. 2021 Oct;51(14):2357-2369.
doi: 10.1017/S0033291720000951. Epub 2020 Apr 24. PMID: 32329708

The 12-month prevalence of psychotic experiences and their association with clinical outcomes in Hong Kong: an epidemiological and a 2-year follow up studies.
Chan SKW, Lee KKW, Chan VHY, Pang HH, Wong CSM, Hui CLM, Chang WC, Lee EHM, Chan WC, Cheung EFC, Chiu HFK, Chiang TP, Lam M, Lau JTF, Ng RMK, Hung SF, Lam LCW, Chen EYH.
Psychol Med. 2021 Oct;51(14):2501-2508.
doi: 10.1017/S0033291720001452. Epub 2020 May 29. PMID: 32466813

An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study.
Wong OWH, Lam AMW, Lai KYC, Ma SL, Hung SF, Chan S, Wong S, Leung PWL.
Autism Res. 2021 Oct;14(10):2131-2142.
doi: 10.1002/aur.2555. Epub 2021 Jun 11. PMID: 34114351

Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action.
Liu L, Ni SY, Yan W, Lu QD, Zhao YM, Xu YY, Mei H, Shi L, Yuan K, Han Y, Deng JH, Sun YK, Meng SQ, Jiang ZD, Zeng N, Que JY, Zheng YB, Yang BN, Gong YM, Ravindran AV, Kosten T, Wing YK, Tang XD, Yuan JL, Wu P, Shi J, Bao YP, Lu L.
EClinicalMedicine. 2021 Oct;40:101111.
doi: 10.1016/j.eclinm.2021.101111. Epub 2021 Sep 8. PMID: 34514362

Associations of circadian factors with insomnia symptoms and emotional and behavioral problems among school-age children.
Sun W, Kwok NTT, Chan NY, Chan JWY, Zhang J, Chan KC, Li SX.
J Clin Sleep Med. 2021 Oct 1;17(10):2107-2114.
doi: 10.5664/jcsm.9346. PMID: 34606443

Neural Response to Rewards in Youths with Insomnia.
Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX.
Sleep. 2021 Oct 4:zsab238.
doi: 10.1093/sleep/zsab238. Online ahead of print. PMID: 34604904

Progressive Pontine-Medullary Dysfunction Leads to REM Sleep Behavior Disorder Symptoms in a Chronic Model of Parkinson’s Disease.
Du L, Xu L, Liang T, Wing YK, Ke Y, Yung WH.
Nat Sci Sleep. 2021 Oct 5;13:1723-1736.
doi: 10.2147/NSS.S328365. eCollection 2021. PMID: 34675721

Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia – A Multi-National Survey Study.
Brandão LEM, Martikainen T, Merikanto I, Holzinger B, Morin CM, Espie CA, Bolstad CJ, Leger D, Chung F, Plazzi G, Dauvilliers Y, Matsui K, De Gennaro L, Sieminski M, Nadorff MR, Chan NY, Wing YK, Mota-Rolim SA, Inoue Y, Partinen M, Benedict C, Bjorvatn B, Cedernaes J.
Nat Sci Sleep. 2021 Oct 6;13:1711-1722.
doi: 10.2147/NSS.S327365. eCollection 2021. PMID: 34675720

Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.
Wang N, Sun Y, Zhang H, Wang B, Chen C, Wang Y, Chen J, Tan X, Zhang J, Xia F, Qi L, Lu Y.
Eur Heart J. 2021 Oct 21;42(40):4180-4188.
doi: 10.1093/eurheartj/ehab505. PMID: 34374755

Mindfulness Awareness Is Associated With a Lower Risk of Anxiety and Depressive Symptoms in Older Adults With Neurocognitive Disorders.
Lam LCW, Lee ATC, Cheng ST, Yip BHK, Chan WC, Fung AWT, Ma SL, Cheng CPW, Kong R, Chiu HTS, Lai FHY, Wong SYS.
Front Psychiatry. 2021 Oct 21;12:721583.
doi: 10.3389/fpsyt.2021.721583. eCollection 2021. PMID: 34744817

Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide.
Liew SL, Zavaliangos-Petropulu A, Schweighofer N, Jahanshad N, Lang CE, Lohse KR, Banaj N, Barisano G, Baugh LA, Bhattacharya AK, Bigjahan B, Borich MR, Boyd LA, Brodtmann A, Buetefisch CM, Byblow WD, Cassidy JM, Charalambous CC, Ciullo V, Conforto AB, Craddock RC, Dula AN, Egorova N, Feng W, Fercho KA, Gregory CM, Hanlon CA, Hayward KS, Holguin JA, Hordacre B, Hwang DH, Kautz SA, Khlif MS, Kim B, Kim H, Kuceyeski A, Lo B, Liu J, Lin D, Lotze M, MacIntosh BJ, Margetis JL, Mohamed FB, Nordvik JE, Petoe MA, Piras F, Raju S, Ramos-Murguialday A, Revill KP, Roberts P, Robertson AD, Schambra HM, Seo NJ, Shiroishi MS, Soekadar SR, Spalletta G, Stinear CM, Suri A, Tang WK, Thielman GT, Thijs VN, Vecchio D, Ward NS, Westlye LT, Winstein CJ, Wittenberg GF, Wong KA, Yu C, Wolf SL, Cramer SC, Thompson PM; ENIGMA Stroke Recovery Working Group.
Brain Commun. 2021 Oct 27;3(4):fcab254.
doi: 10.1093/braincomms/fcab254. eCollection 2021. PMID: 34805997

Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong.
Ho RYF, Zhang D, Chan SKC, Gao TT, Lee EKP, Lo HHM, Au Yeung P, Lai KYC, Bögels SM, de Bruin EI, Wong SYS.
J Autism Dev Disord. 2021 Nov;51(11):4147-4159.
doi: 10.1007/s10803-020-04729-4. PMID: 33484370

Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies.
Chen J, Zhang J, So HC, Ai S, Wang N, Tan X, Wing YK.
J Bone Miner Res. 2021 Nov;36(11):2184-2192.
doi: 10.1002/jbmr.4406. Epub 2021 Jul 8. PMID: 34184784

The trajectories and associations of eveningness and insomnia with daytime sleepiness, depression and suicidal ideation in adolescents: A 3-year longitudinal study.
Chen SJ, Zhang JH, Li SX, Tsang CC, Chan KCC, Au CT, Li AM, Kong APS, Wing YK, Chan NY.
J Affect Disord. 2021 Nov 1;294:533-542.
doi: 10.1016/j.jad.2021.07.033. Epub 2021 Jul 19. PMID: 34330050

Psychological impact on COVID-19 patients during the outbreak in China: A case-control study.
Lu X, Xie Y, Feng H, Liu Z, Ouyang K, Hou B, Wang M, Kong Z, Zhu Z, Dao W, Zhou Y, Cao J, Long J, Xu Y, Liu Y, Yin X.
Psychiatry Res. 2021 Nov;305:114180.
doi: 10.1016/j.psychres.2021.114180. Epub 2021 Aug 23. PMID: 34461357

Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study.
Morin CM, Bjorvatn B, Chung F, Holzinger B, Partinen M, Penzel T, Ivers H, Wing YK, Chan NY, Merikanto I, Mota-Rolim S, Macêdo T, De Gennaro L, Léger D, Dauvilliers Y, Plazzi G, Nadorff MR, Bolstad CJ, Sieminski M, Benedict C, Cedernaes J, Inoue Y, Han F, Espie CA.
Sleep Med. 2021 Nov;87:38-45.
doi: 10.1016/j.sleep.2021.07.035. Epub 2021 Aug 4. PMID: 34508986

Natural History of REM-OSA in Children and Its Associations with Adverse Blood Pressure Outcomes: A Longitudinal Follow-Up Study.
Chan KC, Au CT, Yu MW, Wing YK, Li AM.
Nat Sci Sleep. 2021 Nov 4;13:1967-1984.
doi: 10.2147/NSS.S331389. eCollection 2021. PMID: 34764712

Prevalence and correlates of REM sleep behaviour disorder in patients with major depressive disorder: a two-phase study.
Wang J, Chau SWH, Lam SP, Liu Y, Zhang J, Chan NY, Cheung MMS, Yu MWM, Tsang JCT, Chan JWY, Huang B, Li SX, Mok V, Wing YK.
J Neurol Neurosurg Psychiatry. 2021 Nov 11:jnnp-2021-327460.
doi: 10.1136/jnnp-2021-327460. PMID: 34764151

COVID-19 Vaccine Uptake, Acceptance, and Hesitancy Among Persons With Mental Disorders During the Second Stage of China’s Nationwide Vaccine Rollout.
Huang H, Zhu XM, Liang PW, Fang ZM, Luo W, Ma YM, Zhong BL, Chiu HF.
Front Med (Lausanne). 2021 Nov 11;8:761601.
doi: 10.3389/fmed.2021.761601. eCollection 2021. PMID: 34901076

Effects of COVID-19 on career and specialty choices among Chinese medical students.
Deng J, Que J, Wu S, Zhang Y, Liu J, Chen S, Wu Y, Gong Y, Sun S, Yuan K, Bao Y, Ran M, Shi J, Wing YK, Shi L, Lu L.
Med Educ Online. 2021 Dec;26(1):1913785.
doi: 10.1080/10872981.2021.1913785. PMID: 33849405

Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer’s disease.
Li Z, Ip B, Mok VCT, Ko H.
Neural Regen Res. 2021 Dec;16(12):2411-2412.
doi: 10.4103/1673-5374.313042. PMID: 33907022 .

Altered brain activity related to inhibitory processing in youth with insomnia.
Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX.
J Sleep Res. 2021 Dec;30(6):e13398.
doi: 10.1111/jsr.13398. Epub 2021 Jun 16. PMID: 34137111

Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study.
Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT.
Mov Disord. 2021 Dec;36(12):2821-2832.
doi: 10.1002/mds.28763. Epub 2021 Aug 26. PMID: 34448251

Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial.
Mak ADP, Neggers SFW, Leung ONW, Chu WCW, Ho JYM, Chou IWY, Chan SSM, Lam LCW, Lee S.
Int J Bipolar Disord. 2021 Dec 8;9(1):40.
doi: 10.1186/s40345-021-00245-1. PMID: 34877622

Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire.
Partinen M, Holzinger B, Morin CM, Espie C, Chung F, Penzel T, Benedict C, Bolstad CJ, Cedernaes J, Chan RNY, Dauvilliers Y, De Gennaro L, Han F, Inoue Y, Matsui K, Leger D, Cunha AS, Merikanto I, Mota-Rolim S, Nadorff M, Plazzi G, Schneider J, Sieminski M, Wing YK, Bjorvatn B.
BMJ Open. 2021 Dec 13;11(12):e050672.
doi: 10.1136/bmjopen-2021-050672. PMID: 34903540

Promoting physical activity and health in Hong Kong primary school children through a blended physical literacy intervention: protocol and baseline characteristics of the “Stand+Move” randomized controlled trial.
Li MH, Sit CHP, Wong SHS, Wing YK, Ng CK, Sum RKW.
Trials. 2021 Dec 20;22(1):944.
doi: 10.1186/s13063-021-05925-y. PMID: 34930404

Comprehensive histological imaging of native microbiota in human glioma.
Zhao J, He D, Lai HM, Xu Y, Luo Y, Li T, Liang J, Yang X, Guo L, Ke Y, Zhou H, Wu W, Guo H, Sun H.
J Biophotonics. 2021 Dec 22:e202100351.
doi: 10.1002/jbio.202100351. PMID: 34936211

Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long-COVID – A multinational ICOSS study.
Merikanto I, Dauvilliers Y, Chung F, Holzinger B, De Gennaro L, Wing YK, Korman M, Partinen M; 2nd ICOSS members.
J Sleep Res. 2021 Dec 28:e13542.
doi: 10.1111/jsr.13542. PMID: 34964184

Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial.
Wong A, Lam BYK, Mak MKY, Lam LCW, Au LWC, Yiu BKF, Wong C, Tong HY, Yeung SK, Chu WCW, Shi L, Leung TWH, Soo YOY, Lau AYL, Ip BYM, Kwok TCY, Ko H, Mok VCT.
Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12224.
doi: 10.1002/trc2.12224. eCollection 2021. PMID: 35005205

A bidirectional association between internet addiction and depression: A large-sample longitudinal study among Chinese university students.
Yang X, Guo WJ, Tao YJ, Meng YJ, Wang HY, Li XJ, Zhang YM, Zeng JK, Tang WJ, Wang Q, Deng W, Zhao LS, Ma XH, Li ML, Xu JJ, Li J, Liu YS, Tang Z, Du XD, Hao W, Coid JW, Lee S, Greenshaw AJ, Li T.
J Affect Disord. 2022 Feb 15;299:416-424.
doi: 10.1016/j.jad.2021.12.013. Epub 2021 Dec 11. PMID: 34906641

ADHD Comorbidity Structure and Impairment: Results of the WHO World Mental Health Surveys International College Student Project (WMH-ICS).
Mak ADP, Lee S, Sampson NA, Albor Y, Alonso J, Auerbach RP, Baumeister H, Benjet C, Bruffaerts R, Cuijpers P, Ebert DD, Gutierrez-Garcia RA, Hasking P, Lapsley C, Lochner C, Kessler RC.
J Atten Disord. 2021 Nov 10:10870547211057275.
doi: 10.1177/10870547211057275.

Professor WING Yun Kwok and Dr CHAU Steven Wai Ho were awarded $10 Million in RGC’s Collaborative Research Fund 2021/22

Professor WING Yun Kwok
Title: Multi-modal Approaches to Determine Digital Clinical Phenotyping, Novel Proteomic Biomarkers, and Microbiota-host Responses of REM Sleep Behavior Disorder, a Prodromal Stage of Alphasynucleinopathy Neurodegeneration, in a Prospective Family Cohort
Funded: $7,214,620

Dr CHAU Steven Wai Ho
Title: Neuropsychiatric’ Long-COVID’ in Adult Patients
Funded: $3,251,480

Read more …

Dr. Allen Lee received Best Poster Award in the 15^th International Congress of the Asian Society Against Dementia (ASAD2021)

Dr. Allen Lee’s abstract titled “Structured frontal lobe based computerized cognitive stimulation to older adults with subjective cognitive complaints and comorbid depression symptoms” was one of the 18 posters selected for oral presentation in the 15^th International Congress of the Asian Society Against Dementia (ASAD2021), which was held in a hybrid format in November 2021 in Sendai, Japan.

Dr. Lee’s oral presentation was well received by the audience from Japan and around the world and was subsequently awarded for the Best Poster Award.

His abstract described the positive preliminary findings of his pilot randomized controlled trial of structured frontal lobe based computerized cognitive training in older adults with depression but without mild cognitive impairment or dementia. This pilot study was supported by the CUHK Direct Grant for Research, where Dr. Lee was the Principal Investigator. A larger, longer and more in-depth study could potentially generate the much-needed clinical and scientific evidence of computerized cognitive training being an effective alternative or adjuvant intervention for depression in older adults.

Dr. LU Hanna is appointed as the editorial board member of BMC Medicine

From Oct 2021, Dr. LU Hanna is appointed as the editorial board member of BMC Medicine (https://bmcmedicine.biomedcentral.com/). BMC Medicine is the flagship medical journal of the BMC series (2-year IF: 8.775; 5-year IF: 10.249). An open access, transparent peer-reviewed general medical journal, BMC Medicine publishes outstanding and influential research in all areas of clinical practice, translational medicine, medical and health advances, public health, global health, and general topics of interest to the biomedical and sociomedical professional communities.

The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis.
Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CLH, Lamoureux EL.
Ophthalmology. 2021 Jul;128(7):981-992.
doi: 10.1016/j.ophtha.2020.12.010. Epub 2021 Feb 27. PMID: 33333104.

Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: A randomized controlled study.
Au CT, Chan KCC, Lee DLY, Leung N, Chow SMW, Chow JS, Wing YK, Li AM.
Respirology. 2021 Jul;26(7):690-699.
doi: 10.1111/resp.14050. Epub 2021 Apr 1. PMID: 33793018.

Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images.
Zee B, Wong Y, Lee J, Fan Y, Zeng J, Lam B, Wong A, Shi L, Lee A, Kwok C, Lai M, Mok V, Lau A.
Brain Commun. 2021 Jun 3;3(3):fcab124.
doi: 10.1093/braincomms/fcab124. PMID: 34222872; PMCID:PMC8249101.

Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder.
Si FF, Liu L, Li HM, Sun L, Cao QJ, Lu H, Wang YF, Qian QJ.
Psychiatry Investig. 2021 Jul;18(7):679-687.
doi: 10.30773/pi.2020.0333. Epub 2021 Jul 22. PMID: 34340276; PMCID: PMC8328834.

Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia.Peripheral Blood T Cell Gene Expression Responses to Exercise and HMB in Sarcopenia.
Ma SL, Wu J, Zhu L, Chan RS, Wang X, Huang D, Tang NL, Woo J.
Nutrients. 2021 Jul 5;13(7):2313.
doi: 10.3390/nu13072313. PMID: 34371826; PMCID: PMC8308783.

MRI-Based Geometric Modeling for Personalized Transcranial Magnetic Stimulation in Age-Related Neurodegenerative Diseases.
Lu H.
Front Neurosci. 2021 Jul 22;15:685424.
doi: 10.3389/fnins.2021.685424. PMID: 34366775; PMCID: PMC8339904.

Cardiovascular risks of children with primary snoring: A 5-year follow-up study.
Au CT, Chan KC, Chook P, Wing YK, Li AM.
Respirology. 2021 Aug;26(8):796-803.
doi: 10.1111/resp.14089. Epub 2021 May 30. PMID: 34056796.

Personalized prediction of repetitive transcranial magnetic stimulation clinical response in medication-refractory depression data.
Hopman H, Chan S, Chu W, Lu H, Tse CY, Chau S, Lam L, Mak A, Neggers S.
Data Brief. 2021 Jul 14;37:107264.
doi: 10.1016/j.dib.2021.107264. PMID: 34345639; PMCID: PMC8319357.

Do people with mental health problems have lower adherence to precautionary measures in COVID-19 pandemic? A cross-sectional observational study in Hong Kong.
Lee ATC, Cheng GWH, Lin C, Wong BHC, Lam LCW.
BMJ Open. 2021 Aug 12;11(8):e046658.
doi: 10.1136/bmjopen-2020-046658. PMID: 34385242; PMCID: PMC8361707.

Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort.
Lei B, Zhang J, Chen S, Chen J, Yang L, Ai S, Chan NY, Wang J, Dai XJ, Feng H, Liu Y, Li SX, Jia F, Wing YK.
Sleep. 2021 Aug 13;44(8):zsab053.
doi: 10.1093/sleep/zsab053. PMID: 33640972.

Analysis of genetic differences between psychiatric disorders: exploring pathways and cell types/tissues involved and ability to differentiate the disorders by polygenic scores.
Rao S, Yin L, Xiang Y, So HC.
Transl Psychiatry. 2021 Aug 13;11(1):426.
doi: 10.1038/s41398-021-01545-x. PMID: 34389699; PMCID: PMC8363629.

Inpatient Stay for Older Adults: A Double-edged Sword for Cognition? Inpatient Stay for Older Adults: A Double-edged Sword for Cognition?
Lee ATC, Chiu HFK.
Int Psychogeriatr. 2021 Aug 16:1-5.
doi: 10.1017/S1041610221001137. Epub ahead of print. PMID: 34392863.

Childhood adversities and suicidal thoughts and behaviors among first-year college students: results from the WMH-ICS initiative.
Mortier P, Alonso J, Auerbach RP, Bantjes J, Benjet C, Bruffaerts R, Cuijpers P, Ebert DD, Green JG, Hasking P, Karyotaki E, Kiekens G, Mak A, Nock MK, O’Neill S, Pinder-Amaker S, Sampson NA, Stein DJ, Vilagut G, Wilks C, Zaslavsky AM, Mair P, Kessler RC; WHO WMH-ICS Collaborators.
Soc Psychiatry Psychiatr Epidemiol. 2021 Aug 23.
doi: 10.1007/s00127-021-02151-4. Epub ahead of print. PMID: 34424350.

Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic – Multinational study on 19,267 adults.
Merikanto I, Kortesoja L, Benedict C, Chung F, Cedernaes J, Espie CA, Morin CM, Dauvilliers Y, Partinen M, De Gennaro L, Wing YK, Chan NY, Inoue Y, Matsui K, Holzinger B, Plazzi G, Mota-Rolim SA, Leger D, Penzel T, Bjorvatn B.
Sleep. 2021 Aug 25:zsab216.
doi: 10.1093/sleep/zsab216. Epub ahead of print. PMID: 34432058; PMCID: PMC8499764.

Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study.
Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT.
Mov Disord. 2021 Aug 26.
doi: 10.1002/mds.28763. Epub ahead of print. PMID: 34448251.

Are Care-Recipient Outcomes Attributable to Improved Caregiver Well-Being? A Cluster-Randomized Controlled Trial of Benefit-Finding Intervention.
Cheng ST, Chan WC, Lam LCW.
Am J Geriatr Psychiatry. 2021 Aug 28:S1064-7481(21)00452-8.
doi: 10.1016/j.jagp.2021.08.009. Epub ahead of print. PMID: 34563429.

Wilson Sims Fall Risk Assessment Tool Versus Morse Fall Scale in Psychogeriatric Inpatients: a Multicentre Study.Wilson Sims Fall Risk Assessment Tool Versus Morse Fall Scale in Psychogeriatric Inpatients: a Multicentre Study.
Wong MMC, Pang PF, Chan CF, Lau MS, Tse WY, Lam LCW, Lee SKL, Tsoh J, Yan CTY.
East Asian Arch Psychiatry. 2021 Sep;31(3):67-70.
doi: 10.12809/eaap2113. PMID: 34588316.

Computer-Assisted Cognitive Training for Patients with Severe Mental Illness: a Retrospective Study.
Lau CM, Tang WK.
East Asian Arch Psychiatry. 2021 Sep;31(3):71-80.
doi: 10.12809/eaap2097. PMID: 34588317.

Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank. Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank.
Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SW, Chen J, Tan X, Jia F, Tang X, Shi J, Lu L, Wing YK.
Eur Heart J. 2021 Sep 7;42(34):3349-3357.
doi: 10.1093/eurheartj/ehab170. PMID: 33822910.

Exploring Drugs and Vaccines Associated with Altered Risks and Severity of COVID-19: A UK Biobank Cohort Study of All ATC Level-4 Drug Categories Reveals Repositioning Opportunities.
Xiang Y, Wong KC, So HC.
Pharmaceutics. 2021 Sep 18;13(9):1514.
doi: 10.3390/pharmaceutics13091514. PMID: 34575590; PMCID: PMC8471264.

Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.
Chan JW, Chan NY, Li SX, Lam SP, Chau SWH, Liu Y, Zhang J, Wing YK.
J Clin Sleep Med. 2021 Sep 21.
doi: 10.5664/jcsm.9648. Epub ahead of print. PMID: 34534071.

How our Dreams Changed During the COVID-19 Pandemic: Effects and Correlates of Dream Recall Frequency – a Multinational Study on 19,355 Adults.
Fränkl E, Scarpelli S, Nadorff MR, Bjorvatn B, Bolstad CJ, Chan NY, Chung F, Dauvilliers Y, Espie CA, Inoue Y, Leger D, Macêdo T, Matsui K, Merikanto I, Morin CM, Mota-Rolim S, Partinen M, Penzel T, Plazzi G, Sieminski M, Wing YK, De Gennaro L, Holzinger B.
Nat Sci Sleep. 2021 Sep 22;13:1573-1591.
doi: 10.2147/NSS.S324142. PMID: 34588830; PMCID: PMC8473566.

Uncovering Clinical Risk Factors and Predicting Severe COVID-19 Cases Using UK Biobank Data: Machine Learning Approach.
Wong KC, Xiang Y, Yin L, So HC.
JMIR Public Health Surveill. 2021 Sep 30;7(9):e29544.
doi: 10.2196/29544. PMID: 34591027; PMCID: PMC8485986.

Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action.
Liu L, Ni SY, Yan W, Lu QD, Zhao YM, Xu YY, Mei H, Shi L, Yuan K, Han Y, Deng JH, Sun YK, Meng SQ, Jiang ZD, Zeng N, Que JY, Zheng YB, Yang BN, Gong YM, Ravindran AV, Kosten T, Wing YK, Tang XD, Yuan JL, Wu P, Shi J, Bao YP, Lu L.
EClinicalMedicine. 2021 Oct;40:101111.
doi: 10.1016/j.eclinm.2021.101111. Epub 2021 Sep 8. PMID: 34514362; PMCID: PMC8424080.

Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies.
Chen J, Zhang J, So HC, Ai S, Wang N, Tan X, Wing YK.
J Bone Miner Res. 2021 Nov;36(11):2184-2192.
doi: 10.1002/jbmr.4406. Epub 2021 Jul 8. PMID: 34184784.

The trajectories and associations of eveningness and insomnia with daytime sleepiness, depression and suicidal ideation in adolescents: A 3-year longitudinal study.
Chen SJ, Zhang JH, Li SX, Tsang CC, Chan KCC, Au CT, Li AM, Kong APS, Wing YK, Chan NY.
J Affect Disord. 2021 Nov 1;294:533-542.
doi: 10.1016/j.jad.2021.07.033. Epub 2021 Jul 19. PMID: 34330050.

Psychological impact on COVID-19 patients during the outbreak in China: A case-control study.
Lu X, Xie Y, Feng H, Liu Z, Ouyang K, Hou B, Wang M, Kong Z, Zhu Z, Dao W, Zhou Y, Cao J, Long J, Xu Y, Liu Y, Yin X.
Psychiatry Res. 2021 Nov;305:114180.
doi: 10.1016/j.psychres.2021.114180. Epub 2021 Aug 23. PMID: 34461357; PMCID: PMC8381686.

Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study. Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study.
Morin CM, Bjorvatn B, Chung F, Holzinger B, Partinen M, Penzel T, Ivers H, Wing YK, Chan NY, Merikanto I, Mota-Rolim S, Macêdo T, De Gennaro L, Léger D, Dauvilliers Y, Plazzi G, Nadorff MR, Bolstad CJ, Sieminski M, Benedict C, Cedernaes J, Inoue Y, Han F, Espie CA.
Sleep Med. 2021 Nov;87:38-45.
doi: 10.1016/j.sleep.2021.07.035. Epub 2021 Aug 4. PMID: 34508986; PMCID: PMC8425785.

Intermediate phenotypes of childhood obstructive sleep apnea.
Au CT, Chan KC, Zhang J, Liu KH, Chu WCW, Wing YK, Li AM.
J Sleep Res. 2021 Jun;30(3):e13191.
doi: 10.1111/jsr.13191. Epub 2020 Sep 14. PMID: 32926500.

Optimised tissue clearing minimises distortion and destruction during tissue delipidation.
Lee K, Lai HM, Soerensen MH, Hui ES, Ma VW, Cho WC, Ho YS, Chang RC.
Neuropathol Appl Neurobiol. 2021 Apr;47(3):441-453.
doi: 10.1111/nan.12673. Epub 2020 Dec 2. PMID: 33107057; PMCID: PMC8048831.

Genetic Overlap Between Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in SHANK2 Gene.
Ma SL, Chen LH, Lee CC, Lai KYC, Hung SF, Tang CP, Ho TP, Shea C, Mo F, Mak TSH, Sham PC, Leung PWL.
Front Neurosci. 2021 Apr 27;15:649588.
doi: 10.3389/fnins.2021.649588. PMID: 33986640; PMCID: PMC8111170.

The Effects of Repetitive Transcranial Magnetic Stimulation Antidepressant Response on Cold Cognition: A Single-Arm Prospective Longitudinal Study.
Hopman HJ, Choy HY, Ho WS, Lu H, Wong WHO, Chan SMS.
Neuropsychiatr Dis Treat. 2021 May 26;17:1647-1658.
doi: 10.2147/NDT.S307119. PMID: 34079262; PMCID: PMC8165208.

Effect of surgical intervention for mild childhood obstructive sleep apnoea on attention and behavioural outcomes: A randomized controlled study.
Au CT, Chan KCC, Lee DLY, Leung N, Chow SMW, Chow JS, Wing YK, Li AM.
Respirology. 2021 Jul;26(7):690-699.
doi: 10.1111/resp.14050. Epub 2021 Apr 1. PMID: 33793018.\

An evaluation of the mental health impact of SARS-CoV-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis.
Phiri P, Ramakrishnan R, Rathod S, Elliot K, Thayanandan T, Sandle N, Haque N, Chau SW, Wong OW, Chan SS, Wong EK, Raymont V, Au-Yeung SK, Kingdon D, Delanerolle G.
EClinicalMedicine. 2021 Apr;34:100806.
doi: 10.1016/j.eclinm.2021.100806. Epub 2021 Apr 6. PMID: 33842872; PMCID: PMC8022621.

Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank. 
Ai S, Zhang J, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SW, Chen J, Tan X, Jia F, Tang X, Shi J, Lu L, Wing YK.
Eur Heart J. 2021 Apr 5:ehab170.
doi: 10.1093/eurheartj/ehab170. Epub ahead of print. PMID: 33822910.

History for some or lesson for all? A systematic review and meta-analysis on the immediate and long-term mental health impact of the 2002-2003 Severe Acute Respiratory Syndrome (SARS) outbreak.
Chau SWH, Wong OWH, Ramakrishnan R, Chan SSM, Wong EKY, Li PYT, Raymont V, Elliot K, Rathod S, Delanerolle G, Phiri P.
BMC Public Health. 2021 Apr 7;21(1):670.
doi: 10.1186/s12889-021-10701-3. PMID: 33827499; PMCID: PMC8025448.

Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir.
Lo HS, Hui KPY, Lai HM, He X, Khan KS, Kaur S, Huang J, Li Z, Chan AKN, Cheung HH, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PM, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok CKP, Ko H, Aik WS, Chan MCW, Ng WL.
ACS Cent Sci. 2021 May 26;7(5):792-802.
doi: 10.1021/acscentsci.0c01186. Epub 2021 Apr 15. PMID: 34075346; PMCID: PMC8056950.

The association between high risk of sleep apnea, comorbidities, and risk of COVID-19: a population-based international harmonized study.
Chung F, Waseem R, Pham C, Penzel T, Han F, Bjorvatn B, Morin CM, Holzinger B, Espie CA, Benedict C, Cedernaes J, Saaresranta T, Wing YK, Nadorff MR, Dauvilliers Y, De Gennaro L, Plazzi G, Merikanto I, Matsui K, Leger D, Sieminski M, Mota-Rolim S, Inoue Y, Partinen M; International COVID Sleep Study (ICOSS) group.
Sleep Breath. 2021 Jun;25(2):849-860.
doi: 10.1007/s11325-021-02373-5. Epub 2021 Apr 28. PMID: 33907966; PMCID: PMC8079162.

Knowledge of mental health symptoms and help seeking attitude in a population-based sample in Hong Kong.
Fung AWT, Lam LCW, Chan SSM, Lee S.
Int J Ment Health Syst. 2021 Apr 28;15(1):39.
doi: 10.1186/s13033-021-00462-2. PMID: 33910611; PMCID: PMC8080995.

Mental Health and Psychological Responses During the Coronavirus Disease 2019 Epidemic: A Comparison Between Wuhan and Other Areas in China.
Wang Q, Feng H, Wang M, Xie Y, Hou B, Lu X, Liu Z, Ouyang K, Zhang R, Cai Q, Xu Z, Li H, Chao H, Yang X, Hong Y, Hu X, Liu Z, Liu Y.
Psychosom Med. 2021 May 1;83(4):322-327.
doi: 10.1097/PSY.0000000000000892. PMID: 33284256.

The Differential Effects of Social Media on Depressive Symptoms and Suicidal Ideation Among the Younger and Older Adult Population in Hong Kong During the COVID-19 Pandemic: Population-Based Cross-sectional Survey Study.
Yang X, Yip BHK, Mak ADP, Zhang D, Lee EKP, Wong SYS.
JMIR Public Health Surveill. 2021 May 25;7(5):e24623.
doi: 10.2196/24623. PMID: 33835937; PMCID: PMC8153033.

A framework to decipher the genetic architecture of combinations of complex diseases: Applications in cardiovascular medicine.
Yin L, Chau CK, Lin YP, Rao S, Xiang Y, Sham PC, So HC.
Bioinformatics. 2021 May 29:btab417.
doi: 10.1093/bioinformatics/btab417. Epub ahead of print. PMID: 34050728.

Cardiovascular risks of children with primary snoring: A 5-year follow-up study.
Au CT, Chan KC, Chook P, Wing YK, Li AM.
Respirology. 2021 Aug;26(8):796-803.
doi: 10.1111/resp.14089. Epub 2021 May 30. PMID: 34056796.

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner.
Li Z, Chen X, Vong JSL, Zhao L, Huang J, Yan LYC, Ip B, Wing YK, Lai HM, Mok VCT, Ko H.
Commun Biol. 2021 Jun 2;4(1):656.
doi: 10.1038/s42003-021-02208-9. PMID: 34079050; PMCID: PMC8172568.

Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images.
Zee B, Wong Y, Lee J, Fan Y, Zeng J, Lam B, Wong A, Shi L, Lee A, Kwok C, Lai M, Mok V, Lau A.
Brain Commun. 2021 Jun 3;3(3):fcab124.
doi: 10.1093/braincomms/fcab124. PMID: 34222872; PMCID: PMC8249101.

An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study.
Wong OWH, Lam AMW, Lai KYC, Ma SL, Hung SF, Chan S, Wong S, Leung PWL.
Autism Res. 2021 Jun 11.
doi: 10.1002/aur.2555. Epub ahead of print. PMID: 34114351.

Altered brain activity related to inhibitory processing in youth with insomnia.
Ling J, Lin X, Li X, Chan NY, Zhang J, Wing YK, Hu X, Li SX.
J Sleep Res. 2021 Jun 16:e13398.
doi: 10.1111/jsr.13398. Epub ahead of print. PMID: 34137111.

Non-suicidal self-injury among first-year college students and its association with mental disorders: results from the World Mental Health International College Student (WMH-ICS) initiative.
Kiekens G, Hasking P, Bruffaerts R, Alonso J, Auerbach RP, Bantjes J, Benjet C, Boyes M, Chiu WT, Claes L, Cuijpers P, Ebert DD, Mak A, Mortier P, O’Neill S, Sampson NA, Stein DJ, Vilagut G, Nock MK, Kessler RC; WHO World Mental Health International College Student (WMH-ICS) collaborators.
Psychol Med. 2021 Jun 18:1-12.
doi: 10.1017/S0033291721002245. Epub ahead of print. PMID: 34140062.

Linking cohort-based data with electronic health records: a proof-of-concept methodological study in Hong Kong.
Gao L, Leung MTY, Li X, Chui CSL, Wong RSM, Au Yeung SL, Chan EWW, Chan AYL, Chan EW, Wong WHS, Lee TMC, Rao N, Wing YK, Lum TYS, Leung GM, Ip P, Wong ICK.
BMJ Open. 2021 Jun 22;11(6):e045868.
doi: 10.1136/bmjopen-2020-045868. PMID: 34158297; PMCID: PMC8220454.

Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies.
Chen J, Zhang J, So HC, Ai S, Wang N, Tan X, Wing YK.
J Bone Miner Res. 2021 Jun 29.
doi: 10.1002/jbmr.4406. Epub ahead of print. PMID: 34184784.

The clinical characteristics of cataplectic attack in narcolepsy type 1.
Huang B, Xu T, Wang Z, Chen K, Zhang J, Zhao Z, Zhuang J, Wu H.
Sleep Med. 2021 Jan;77:261-269. doi: 10.1016/j.sleep.2019.03.015. Epub 2019 Apr 3. PMID:31607435.

Moment-to-moment dynamics between auditory verbal hallucinations and negative affect and the role of beliefs about voices.
So SH, Chung LK, Tse CY, Chan SS, Chong GH, Hung KS, Sommer IEC.
Psychol Med. 2021 Mar;51(4):661-667. doi:10.1017/S0033291719003611. Epub 2020 Jan 7. PMID: 31907105.

Cultural variations in wellbeing, burnout and substance use amongst medical students in twelve countries.
Molodynski A, Lewis T, Kadhum M, Farrell SM, Lemtiri Chelieh M, Falcão De Almeida T, Masri R, Kar A, Volpe U, Moir F, Torales J, Castaldelli-Maia JM, Chau
SWH, Wilkes C, Bhugra D.
Int Rev Psychiatry. 2021 Feb-Mar;33(1-2):37-42. doi: 10.1080/09540261.2020.1738064. Epub 2020 Mar 18. PMID:32186412.

Urban-rural disparities in mental health problems related to COVID-19 in China.
Liu L, Xue P, Li SX, Zhang J, Zhou J, Zhang W.
Gen Hosp Psychiatry. 2021 Mar-Apr;69:119-120. doi: 10.1016/j.genhosppsych.2020.07.011. Epub 2020 Aug 2. PMID: 32868097; PMCID: PMC7395944.

A randomised controlled trial of metacognitive training for psychosis, depression, and belief flexibility.
Ho-Wai So S, Hoi-Kei Chan G, Kit-Wa Wong C, Wing-Ka Ching E, Sze-Wai Lee S, Chi-Wing Wong B, Zhu C, Sun X, Kin-Hei Chung L, Hung AY, Oi-Yin Wong J, Sau-Man Chan S.
J Affect Disord. 2021 Jan 15;279:388-397. doi: 10.1016/j.jad.2020.09.126. Epub 2020 Oct 6. PMID: 33099054.

Efficacy of Phase 1 of Life Goals Programme on symptom reduction and mood stability for bipolar disorder.
So SH, Mak AD, Chan PS, Lo CC, Na S, Leung MH, Ng IH, Chau AKC, Lee S.
J Affect Disord. 2021 Feb 15;281:949-957. doi: 10.1016/j.jad.2020.11.019. Epub 2020 Nov 18. PMID: 33229019.

Letter to Editor.
Zhang C, Tang WK.
Psychiatry Res. 2021 Feb;296:113602. doi: 10.1016/j.psychres.2020.113602. Epub 2020 Nov 26. PMID: 33279254.

Current Status of Tissue Clearing and the Path Forward in Neuroscience.
Zhao J, Lai HM, Qi Y, He D, Sun H.
ACS Chem Neurosci. 2021 Jan 6;12(1):5-29. doi: 10.1021/acschemneuro.0c00563. Epub 2020 Dec 16. PMID: 33326739.

The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study.
Lui TK, Shum YH, Xiao XZ, Wang Y, Cheung AT, Chan SS, Neggers SFW, Tse CY.
Brain Stimul. 2021 Jan-Feb;14(1):161-169. doi: 10.1016/j.brs.2020.12.005. Epub 2020 Dec 17. PMID: 33346067.

Risk of incident dementia varies with different onset and courses of depression.
Lee ATC, Fung AWT, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
J Affect Disord. 2021 Mar 1;282:915-920. doi: 10.1016/j.jad.2020.12.195. Epub 2020 Dec 30. PMID: 33601735.

Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling.
Lu H, Li J, Zhang L, Chan SSM, Lam LCW;
J Neuroeng Rehabil. 2021 Jan 4;18(1):2. doi: 10.1186/s12984-020-00764-5. PMID:33397402; PMCID: PMC7784346.

White matter integrity in young medication-naïve bipolar II depressed adults.
Mak ADP, Leung ONW, Chou IWY, Wong SLY, Chu WC, Yeung D, So SH, Ma SL, Lam LCW, Leung CM, Lee S.
Sci Rep. 2021 Jan 19;11(1):1816. doi:10.1038/s41598-021-81355-9. PMID: 33469064; PMCID: PMC7815920.

Brief Report: Mindfulness Training for Chinese Adolescents with Autism Spectrum Disorder and Their Parents in Hong Kong.
Ho RYF, Zhang D, Chan SKC, Gao TT, Lee EKP, Lo HHM, Au Yeung P, Lai KYC, Bögels SM, de Bruin EI, Wong SYS.
J Autism Dev Disord. 2021 Jan 23. doi: 10.1007/s10803-020-04729-4. Epub ahead of print. PMID: 33484370.

Promoting Resilience in the Age of COVID-19 Pandemic: A New Era of Strategic Foresight.
Lu H, Li J, Ni X.
Aging Dis. 2021 Feb 1;12(1):1-2. doi:10.14336/AD.2020.1011. PMID: 33532120; PMCID: PMC7801285.

The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis.
Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CLH, Lamoureux EL.
Ophthalmology. 2021 Feb 26:S0161-6420(20)31158-1. doi:10.1016/j.ophtha.2020.12.010. Epub ahead of print. PMID: 33333104.

Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort.
Lei B, Zhang J, Chen S, Chen J, Yang L, Ai S, Chan NY, Wang J, Dai XJ, Feng H, Liu Y, Li SX, Jia F, Wing YK.
Sleep. 2021 Feb 26:zsab053. doi: 10.1093/sleep/zsab053. Epub ahead of print. PMID:33640972.

Exercise for the prevention and treatment of neurocognitive disorders: new evidence and clinical recommendations.
Chan WC, Lee ATC, Lam LCW.
Curr Opin Psychiatry. 2021 Mar 1;34(2):136-141. doi: 10.1097/YCO.0000000000000678. PMID:33470667.

Achieving better outcomes for schizophrenia patients in Hong Kong: Strategies for improving treatment adherence.adherence.
Lo WA, Ki-Yan Mak D, Ming-Cheuk Wong M, Chan OW, Mo-Ching Chui E, Wai-Sau Chung D, Suk-Han Ip G, Lau KS, Lee CK, Mui J, Tam KL, Tse S, Wong KL; Hong Kong Association of Psychosocial Rehabilitation (HKAPR).
CNS Neurosci Ther. 2021 Mar;27 Suppl 1(Suppl 1):12-19. doi:10.1111/cns.13375. PMID: 33555616; PMCID: PMC7869929.

A Prevention Program for Insomnia in At-risk Adolescents: A Randomized Controlled Study.
Chan NY, Li SX, Zhang J, Lam SP, Kwok APL, Yu MWM, Chan JWY, Li AM, Morin CM, Wing YK.
Pediatrics. 2021 Mar;147(3):e2020006833. doi:10.1542/peds.2020-006833. PMID: 33627370.

Prevalence of depressive symptoms among Chinese university students amid the COVID-19 pandemic: a systematic review and meta-analysis.
Luo W, Zhong BL, Chiu HF.
Epidemiol Psychiatr Sci. 2021 Mar 26;30:e31. doi:10.1017/S2045796021000202. PMID: 33766163; PMCID: PMC8047400.

CUHK Study Proves Genetically Predicted Short Sleep Duration Rather Than Long Sleep Duration as a Potential Causal Risk Factor for Many Cardiovascular Diseases

CUHK-HKU-UL Conducts World’s First Insomnia Prevention Programme and Proves Insomnia is Preventable in At-risk Adolescents

Adolescence is a critical period accompanied by dramatic neurobiological, physical, behavioural and emotional changes, predisposing the youngsters to sleep disorders, mental and physical illnesses. It is a vulnerable period for the emergence of insomnia, affecting 10% to 36% of the adolescents. Insomnia once developed, tends to run a chronic course with considerable personal distress and health care burden.

The associations of insomnia symptoms and chronotype with daytime sleepiness, mood symptoms and suicide risk in adolescents.
Chan NY, Zhang J, Tsang CC, Li AM, Chan JWY, Wing YK, Li SX.
Sleep Med. 2020 Oct;74:124-131. doi: 10.1016/j.sleep.2020.05.035. Epub 2020 Jun 3. PMID: 32853897.

The mental health of frontline and non-frontline medical workers during the coronavirus disease 2019 (COVID-19) outbreak in China: A case-control study.
Cai Q, Feng H, Huang J, Wang M, Wang Q, Lu X, Xie Y, Wang X, Liu Z, Hou B, Ouyang K, Pan J, Li Q, Fu B, Deng Y, Liu Y.
J Affect Disord. 2020 Oct 1;275:210-215. doi: 10.1016/j.jad.2020.06.031. Epub 2020 Jul 2. PMID: 32734910; PMCID: PMC7329671.

Education and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment.
Makkar SR, Lipnicki DM, Crawford JD, Kochan NA, Castro-Costa E, Lima-Costa MF, Diniz BS, Brayne C, Stephan B, Matthews F, Llibre-Rodriguez JJ, Llibre-Guerra JJ, Valhuerdi-Cepero AJ, Lipton RB, Katz MJ, Zammit A, Ritchie K, Carles S, Carriere I, Scarmeas N, Yannakoulia M, Kosmidis M, Lam L, Fung A, Chan WC, Guaita A, Vaccaro R, Davin A, Kim KW, Han JW, Suh SW, Riedel-Heller SG, Roehr S, Pabst A, Ganguli M, Hughes TF, Jacobsen EP, Anstey KJ, Cherbuin N, Haan MN, Aiello AE, Dang K, Kumagai S, Narazaki K, Chen S, Ng TP, Gao Q, Nyunt MSZ, Meguro K, Yamaguchi S, Ishii H, Lobo A, Lobo Escolar E, De la Cámara C, Brodaty H, Trollor JN, Leung Y, Lo JW, Sachdev P; for Cohort Studies of Memory in an International Consortium (COSMIC).
Arch Gerontol Geriatr. 2020 Nov/Dec;91:104112. doi: 10.1016/j.archger.2020.104112. Epub 2020 Jul 13. PMID: 32738518; PMCID: PMC7724926.

Residual Injurious Symptoms and Its Association With Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-up Study.
Wang J, Liu Y, Chau SWH, Zhang J, Tsang J, Yu MWM, Chan NY, Chan JWY, Li SX, Huang B, Feng H, Mok V, Wing YK.
Mov Disord. 2020  Nov;35(11):2077-2085. doi: 10.1002/mds.28210. Epub 2020 Aug 3. PMID: 32744735.

Tackling challenges in care of  Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future.
Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O’Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P.
Alzheimers Dement. 2020 Nov;16(11):1571-1581. doi: 10.1002/alz.12143. Epub 2020 Aug 12. PMID: 32789951; PMCID: PMC7436526.

Rest-Activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder.
Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MWM, Huang B, Li SX, Chau SWH, Chan JWY, Chen J, Mok VCT, Wing YK, Zhang J.
Ann Neurol. 2020 Oct;88(4):817-829. doi:10.1002/ana.25853. Epub 2020 Aug 18. PMID: 32691442.

Sleep duration in preschool children and impact of screen time.
Lan QY, Chan KC, Yu KN, Chan NY, Wing YK, Li AM, Au CT.
Sleep Med. 2020 Dec;76:48-54. doi:10.1016/j.sleep.2020.09.024. Epub 2020 Oct 1. PMID: 33091726.

COVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences.
Xie Q, Fan F, Fan XP, Wang XJ, Chen MJ, Zhong BL, Chiu HF.
Transl Psychiatry. 2020 Oct 2;10(1):337. doi:10.1038/s41398-020-01022-x. PMID: 33009366; PMCID: PMC7531059.

A randomised controlled trial of metacognitive training for psychosis, depression, and belief flexibility.
Ho-Wai So S, Hoi-Kei Chan G, Kit-Wa Wong C, Wing-Ka Ching E, Sze-Wai Lee S, Chi-Wing Wong B, Zhu C, Sun X, Kin-Hei Chung L, Hung AY, Oi-Yin Wong J, Sau-Man Chan S.
J Affect Disord. 2021 Jan 15;279:388-397. doi: 10.1016/j.jad.2020.09.126. Epub 2020 Oct 6. PMID: 33099054.

Prolonged visual fixation as a surrogate marker of cholinergic deficit in Parkinson’s disease: A 2-year follow-up study.
Wong OW, Chan A, Wong A, Lau CK, Yeung JH, Mok V, Chan S.
Parkinsonism Relat Disord. 2020 Dec;81:60-66. doi:10.1016/j.parkreldis.2020.10.019. Epub 2020 Oct 11. PMID: 33059183.

Higher Dementia Incidence in Older Adults with Poor Visual Acuity.
Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW.
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2162-2168. doi: 10.1093/gerona/glaa036. PMID: 32043518; PMCID: PMC7566398.

Benefit-Finding Intervention Delivered Individually to Alzheimer Family Caregivers: Longer-Term Outcomes of a Randomized Double-Blind Controlled Trial.
Cheng ST, Mak EPM, Kwok T, Fung H, Lam LCW.
J Gerontol B Psychol Sci Soc Sci. 2020 Oct 16;75(9):1884-1893. doi: 10.1093/geronb/gbz118. PMID: 31556447.

The Protective Effect of Daytime Sleep on Planning and Risk-Related Decision Making in Emerging Adults.
Wong ML, Lau EYY, Lam YC, Rusak B, Tseng CH, Lee TMC, Wing YK.
Soc Cogn Affect Neurosci. 2020 Oct 16;15(11):1228–37. doi:10.1093/scan/nsaa140. Epub ahead of print. PMID: 33064803; PMCID: PMC7745149.

Optimised tissue clearing minimises distortion and destruction during tissue delipidation.
Lee K, Lai HM, Soerensen MH, Hui ES, Ma VW, Cho WC, Ho YS, Chang RC.
Neuropathol Appl Neurobiol. 2020 Oct 26. doi: 10.1111/nan.12673. Epub ahead of print. PMID: 33107057.

Mental health problems, needs, and service use among people living within and outside Wuhan during the COVID-19 epidemic in China.
Zhong BL, Zhou DY, He MF, Li Y, Li WT, Ng CH, Xiang YT, Chiu HF.
Ann Transl Med. 2020 Nov;8(21):1392. doi: 10.21037/atm-20-4145. PMID: 33313137; PMCID: PMC7723535.

Efficacy of Phase 1 of Life Goals Programme on symptom reduction and mood stability for bipolar disorder.
So SH, Mak AD, Chan PS, Lo CC, Na S, Leung MH, Ng IH, Chau AKC, Lee S.
J Affect Disord. 2021 Feb 15;281:949-957. doi:10.1016/j.jad.2020.11.019. Epub 2020 Nov 18. PMID: 33229019.

Letter to Editor.
Zhang C, Tang WK.
Psychiatry Res. 2021 Feb;296:113602. doi: 10.1016/j.psychres.2020.113602. Epub 2020 Nov 26. PMID: 33279254.

Behavioural dysexecutive syndrome after stroke: abridged secondary publication.
Tang WK, Wong KSL, Mok VCT, Chu CWW, Wang D, Wong A.
Hong Kong Med J. 2020 Dec;26 Suppl 6(6):30-33. PMID: 33229601.

Aerobic dance for cognitive and physical functions and mood in older adults with cerebral small vessel disease: abridged secondary publication.
Wong A, Mak MKY, Lam LCW, Mok VCT.
Hong Kong Med J. 2020 Dec;26 Suppl 6(6):38-41. PMID:33229603.

Home-based exercise intervention for caregivers of persons with dementia: a randomised controlled trial: abridged secondary publication.
Chan WC, Lam LCW, Lautenschlager N, Dow B, Ma SL.
Hong Kong Med J. 2020 Dec;26 Suppl 7(6):13-16. PMID: 33229611.

Management of Treatment-Resistant Depression in Real-World Clinical Practice Settings Across Asia.
Wang G, Han C, Liu CY, Chan S, Kato T, Tan W, Zhang L, Feng Y, Ng CH.
Neuropsychiatr Dis Treat. 2020 Dec 3;16:2943-2959. doi:10.2147/NDT.S264813. PMID: 33299316; PMCID: PMC7721287.

Definition and Identification of Patients with Treatment-Resistant Depression in Real-World Clinical Practice Settings Across Asia.
Han C, Wang G, Chan S, Kato T, Ng CH, Tan W, Zhang L, Feng Y, Liu CY.
Neuropsychiatr Dis Treat. 2020 Dec 3;16:2929-2941. doi: 10.2147/NDT.S264799. PMID: 33311981; PMCID: PMC7725069.

Mental health and psychological responses during the coronavirus disease 2019 (COVID-19) epidemic: A comparison between Wuhan and other areas in China.
Wang Q, Feng H, Wang M, Xie Y, Hou B, Lu X, Liu Z, Ouyang K, Zhang R, Cai Q, Xu Z, Li H, Chao H, Yang X, Hong Y, Hu X, Liu Z, Liu Y.
Psychosom Med. 2020 Dec 4. doi: 10.1097/PSY.0000000000000892. Epub ahead of print. PMID: 33284256.

THE BIDIRECTIONAL RELATIONSHIP BETWEEN VISION AND COGNITION: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Vu TA, Fenwick EK, Gan AT, Man RE, Tan BK, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O’Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee AT, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CL, Lamoureux EL.
Ophthalmology. 2020 Dec 14:S0161-6420(20)31158-1. doi: 10.1016/j.ophtha.2020.12.010. Epub ahead of print. PMID: 33333104.

Current Status of Tissue Clearing and the Path Forward in Neuroscience.
Zhao J, Lai HM, Qi Y, He D, Sun H.
ACS Chem Neurosci. 2021 Jan 6;12(1):5-29. doi: 10.1021/acschemneuro.0c00563. Epub 2020 Dec 16. PMID: 33326739.

The critical role of the inferior frontal cortex in establishing a prediction model for generating subsequent mismatch negativity (MMN): A TMS-EEG study.
Lui TK, Shum YH, Xiao XZ, Wang Y, Cheung AT, Chan SS, Neggers SFW, Tse CY.
Brain Stimul. 2021 Jan-Feb;14(1):161-169. doi: 10.1016/j.brs.2020.12.005. Epub 2020 Dec 17. PMID: 33346067.

CUHK-HKU Study Proves Bright Light Therapy as an Adjunctive Treatment Improves Outcomes in Depressed “Night Owl” Patients

Depression is among the most common mental health problems. About 1 in 10 adults in Hong Kong suffer from depressive symptoms. There is growing research suggesting a close relationship between mood disorders and the biological clock. “Night owls”, refers those who are late to bed and late to rise, are at greater risk of poor clinical outcomes with more sleep disturbances and depressive symptoms. The Department of Psychiatry of the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine), in collaboration with the Department of Psychology of the Faculty of Social Sciences at the University of Hong Kong (HKU), have conducted the world’s first randomised controlled trial of adjunctive bright light therapy for “night owls” with depression. Results showed bright light therapy doubles the probability of achieving remission, and the cumulative remission rate of depression reaches 67.4%.     MORE

(From left) Dr. Shirley Li, Assistant Professor of the Department of Psychology, Faculty of Social Sciences at HKU; Professor Yun Kwok WING, Chairman and Dr. Joey Wing Yan CHAN, Associate Professor of the Department of Psychiatry at CU Medicine.

Findings of LANDSCAPE project gets published in the top journal of rehabilitation

Advanced Magnetic Resonance Imaging (MRI) analysis techniques have greatly contributed to detect the anatomical changes in age-related neurodegenerative diseases. With the fast development of transcranial brain stimulation, MRI-based morphometry is increasingly being applied to construct head model and optimize stimulation protocols. For years, converging evidence has accumulated on the clinical trials of brain stimulation, yet, the variability in morphometry limits the application and interpretation at individual level.

In a recent study of research team from the Neuromodulation Lab at the Department of Psychiatry, led by Research Assistant Professor Dr. LU Hanna, performed a study entitled “Localized Analysis of Normalized Distance from Scalp to Cortex and Personalized Evaluation (LANDSCAPE)”. Beyond age-related effects, we focused on ageing effect on region-specific cortical complexity and scalp-to-cortex distance (SCD). We found pronounced ageing effect on the SCD of left dorsolateral prefrontal cortex (DLPFC), not primary motor cortex (M1) in mild cognitive impairment (MCI) converters. The SCD change of left DLPFC from baseline to 3-year follow-up demonstrated better performance to discriminate MCI converters from normal ageing adults than the other morphometric features. The novel findings have been published in the Journal of NeuroEngineering and Rehabilitation (Rank: 2/115 in the field of Rehabilitation).

Significance of the study: The findings of this study have significant implications in morphometric imaging and precision medicine. Firstly, the identification of SCD in MCI converters that region-specific SCD may be used as a novel imaging biomarker for the early detection of dementia; meanwhile, offering valuable information to optimize the dosage of brain stimulation. Secondly, the newly developed method to quantify the SCD-related electric field changes (i.e., information entropy) may help to improve realistic head model, advancing precision medicine for neurodegenerative diseases in clinical trials (Figure 1).

Figure 1. Three-dimensional geometric simulation model of anodal transcranial current stimulation.

Article in Journal of NeuroEngineering and Rehabilitation

“Dynamic changes of region-specific cortical features and scalp-to-cortex distance: implications for transcranial current stimulation modeling” by Hanna Lu, Jing Li, Li Zhang, Sandra Sau Man Chan and Linda Chiu Wa Lam & the Open Access Series of Imaging Studies (OASIS).

Link: https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-020-00764-5

Link to LANDSCAPE project: http://thebrainx.com/landscape/

LANDSCAPE project was supported by the Direct Grant of the Chinese University of Hong Kong (4054495).

Scientific and medical advancements are closely intertwined, psychiatry is no exception. The addition of neuroscience to the department is recent but well primed – guided by our strong track record in community and clinical psychiatry, neuroscience could broaden our scope in investigating psychiatric illness, it also brings novel perspectives in our understanding of clinical phenomena and paves the road to novel intervention and treatment. This completes our department’s multi-pronged approach aiming at easing the sufferings of those who are mentally ill.

RESEARCHERS

Dr. H. M. LAI
Prof. Y.K. WING

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